Althiazide

Product Name: Althiazide
CAS No.: 5588-16-9
Chemical Name: Althiazide
Synonyms: P-1779;Altizid;CB 8093;CB-8093;Althizide;ALTHIAZIDE;Altizide CRS;Altizide (Y0000606);3-[(Allylthio)methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;3-[(allylthio)methyl]-6-chloro-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
CBNumber: CB4739720
Molecular Formula: C11H14ClN3O4S3
Formula Weight: 383.89
MOL File: 5588-16-9.mol

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Althiazide Property

Melting point:: 206-207°
Boiling point:: 625.8±65.0 °C(Predicted)
Density: 1.502±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Practically insoluble in water, soluble in methanol, practically insoluble in dichloromethane.
pka: 8.33±0.40(Predicted)
color: White to Off-White
EPA Substance Registry System: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-[(2-propen-1-ylthio)methyl]-, 1,1-dioxide (5588-16-9)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000606
Product name: Altizide
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000606
Price: $220
Updated: 2024/03/01

Usbiological

Product number: 259084
Product name: Althiazide
Packaging: 5mg
Price: $446
Updated: 2021/12/16

TRC

Product number: A575775
Product name: Althiazide
Packaging: 50mg
Price: $790
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007933
Product name: ALTHIAZIDE
Purity: 95.00%
Packaging: 100MG
Price: $1871.1
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17332
Product name: Althiazide
Packaging: 25mg
Price: $625
Updated: 2021/12/16

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Althiazide Chemical Properties,Usage,Production

Description

Althiazide, also known as altizide, is an agent belonging to the class of thiazide diuretics with antihypertensive activity. This aldosterone antagonist is often combined with spironolactone.

Chemical Properties

White Solid

Originator

Althiazide,Solchem

Uses

Diuretic and antihypertensive.

Definition

ChEBI: Althiazide is a benzothiadiazine. It is the thiazide and sulfonamide derivative.

Manufacturing Process

To 6.75 g (0.0225 mole) of 4-amino-2-chloro-5-(methylsulfamyl) benzenesulfonamide in 45 ml of dimethylformamide is added 4.86 g (0.03 mole) of dimethyl allylmercaptoacetal followed by 1.5 ml ethyl acetate saturated with hydrogen chloride gas. The solution is refluxed for 1.5 hours, cooled and added dropwise with stirring to ice/water. The resulting precipitate is filtered, dried and recrystallized from isopropanol. The recrystallization gave 4.0 g of 2-methyl-3-allylthiomethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide; M.P. 168.5-170°C.

Therapeutic Function

Diuretic, Antihypertensive

Althiazide Preparation Products And Raw materials

Raw materials

Preparation Products

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Althiazide Suppliers

Canada 1 China 25 India 5 Switzerland 1 United Kingdom 2 United States 4 Global 38

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5588-16-9, AlthiazideRelated Search:

o-Chlorobenzenesulfonamide Benzenesulfonamide, 2-(methylamino)- (9CI) 4-Chloro-N-methylbenzenesulphonamide Althiazide Hydrochlorothiazide 2-Aminobenzenesulfonamide 4-Chlorobenzenesulfonamide CLOFENAMIDE 4-Amino-6-chlorobenzene-1,3-disulfonamide Methalthiazide 2-AMINO-N-METHYLBENZENESULFONAMIDE 4-CHLORO-1,3-BENZENEDITHIOL

ALTHIAZIDE

6-CHLORO-3,4-DIHYDRO-3-[(2-PROPENYLTHIO)METHYL]-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE

6-chloro-1,1-dioxo-3-(prop-2-enylsulfanylmethyl)-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide

6-chloro-1,1-dioxo-3-(prop-2-enylsulfanylmethyl)-3,4-dihydro-2H-1λ<sup>6</sup>,2,4-benzothiadiazine-7-sulfonamide

3-[(Allylthio)methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

P-1779

3-[(allylthio)methyl]-6-chloro-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide

6-chloro-1,1-dioxo-3-(prop-2-enylsulfanylmethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide

6-Chloro-3,4-dihydro-3-[(2-propen-1-ylthio)Methyl]-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide

Althizide

Altizid

3-((allylthio)methyl)-6-chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

Altizide CRS

(3RS)-6-Chloro-3-[(prop-2-enylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-[(2-propen-1-ylthio)methyl]-, 1,1-dioxide

Altizide (Y0000606)

CB 8093

CB-8093

Althiazide (3R)-3-[(Allylsulfanyl)methyl]-6-chloro-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide 1,1-dioxide

5588-16-9

C11H14ClN3O4S3

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