Synthesis
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2-Benzoylbenzoic acid

Synthesis
Product Name
2-Benzoylbenzoic acid
CAS No.
85-52-9
Chemical Name
2-Benzoylbenzoic acid
Synonyms
OBBA;skp10a;AKOS BBS-00000803;RARECHEM AL BO 1426;o-benzoyl-benzoicaci;2-benzoyl-benzoicaci;o-Carboxybenzophenone;2-BENZOYLBENZOIC ACID;2-CARBOXYBENZOPHENONE;OTAVA-BB BB7020401721
CBNumber
CB4741530
Molecular Formula
C14H10O3
Formula Weight
226.23
MOL File
85-52-9.mol
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2-Benzoylbenzoic acid Property

Melting point:
126-129 °C (lit.)
Boiling point:
257-265 °C (lit.)
Density 
1.2022 (rough estimate)
refractive index 
1.5767 (estimate)
Flash point:
257°C
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
pK1: 3.54 (25°C)
form 
Crystalline Powder
color 
Almost white to slightly beige
Water Solubility 
284mg/L at 20℃
BRN 
1107841
InChIKey
FGTYTUFKXYPTML-UHFFFAOYSA-N
LogP
1.4 at 35℃
CAS DataBase Reference
85-52-9(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 2-benzoyl-(85-52-9)
EPA Substance Registry System
Benzoic acid, 2-benzoyl- (85-52-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
2
RTECS 
DG3600000
TSCA 
Yes
HS Code 
29183000
Hazardous Substances Data
85-52-9(Hazardous Substances Data)
Toxicity
LD50 orl-rat: 4600 mg/kg GTPZAB 15(11),52,71
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B12385
Product name
2-Benzoylbenzoic acid
Purity
98%
Packaging
25g
Price
$24.36
Updated
2024/03/01
Sigma-Aldrich
Product number
B12385
Product name
2-Benzoylbenzoic acid
Purity
98%
Packaging
500g
Price
$161
Updated
2024/03/01
TCI Chemical
Product number
B0103
Product name
2-Benzoylbenzoic Acid
Purity
>99.0%(T)
Packaging
25g
Price
$21
Updated
2024/03/01
Alfa Aesar
Product number
A13281
Product name
2-Benzoylbenzoic acid
Purity
98+%
Packaging
50g
Price
$33.65
Updated
2024/03/01
Alfa Aesar
Product number
A13281
Product name
2-Benzoylbenzoic acid, 98+%
Packaging
250g
Price
$91.65
Updated
2024/03/01
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2-Benzoylbenzoic acid Chemical Properties,Usage,Production

Synthesis

In the presence of aluminum trichloride, phthalic anhydride and benzene are condensed and obtained by hydrolysis. The hydrochloric acid gas by-product in the reaction should preferably be absorbed into dilute hydrochloric acid for subsequent use. The industrial benzoylbenzoic acid is white to beige powder, the purity is above 97%, and the initial melting point of the dry product is ≥126.0%.

Chemical Properties

ALMOST WHITE TO SLIGHTLY BEIGE CRYSTALLINE POWDER

Uses

2-Benzoylbenzoic Acid is a reagent that is used in the synthesis of BzATP Triethylammonium Salt, which is a selective P2X purinergic agonist. It is more potent than ATP at homodimeric P2X7 receptors.

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 2758, 1948 DOI: 10.1021/ja01188a035
The Journal of Organic Chemistry, 39, p. 2051, 1974 DOI: 10.1021/jo00928a016

Flammability and Explosibility

Not classified

Safety Profile

Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andirritating vapors.

Purification Methods

Recrystallise the acid from *C6H6 or cyclohexane, but it is best recrystallised by dissolving in a small volume of hot toluene and then adding just enough pet ether to cause turbidity, and cool. Dry it in a low vacuum at 80o. It can be sublimed at 230-240o/0.3mm [Bray et al. J Chem Soc 265 1957]. The S-benzylisothiuronium salt has m 177-178o (from EtOH). [Lewenz & Serijan J Am Chem Soc 75 4087 1953, Beilstein 10 H 747, 10 IV 2977.]

2-Benzoylbenzoic acid Preparation Products And Raw materials

Raw materials

Aluminum chloride Benzene Phthalic anhydride Hydrochloric acid Sodium hydroxide Sulfuric acid

Preparation Products

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View Lastest Price from 2-Benzoylbenzoic acid manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-Benzoylbenzoic acid 85-52-9
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-05
hebei hongtan Biotechnology Co., Ltd
Product
2-Benzoylbenzoic acid 85-52-9
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2024-03-25
Hebei Weibang Biotechnology Co., Ltd
Product
2-Benzoylbenzoic acid 85-52-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-01

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