ChemicalBook > CAS DataBase List > 3-Guanidinopropionic acid

3-Guanidinopropionic acid

Product Name
3-Guanidinopropionic acid
CAS No.
353-09-3
Chemical Name
3-Guanidinopropionic acid
Synonyms
β-Guanidinopropionic acid;3-GUANIDINOPROPIONIC ACID;3-Guanidinopropanoate;3-guanidinopropanoicacid;RGX-202;PNU-10483;Ompenaclid;beta-Guanidinopropio;Guanidine propionate;3-Guanidino Propionic
CBNumber
CB4749112
Molecular Formula
C4H9N3O2
Formula Weight
131.13
MOL File
353-09-3.mol
More
Less

3-Guanidinopropionic acid Property

Melting point:
222 °C (dec.)(lit.)
Boiling point:
299.1±42.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Aqueous Acid (Slightly), Water (Slightly, Heated)
form 
Solid
pka
4.22±0.10(Predicted)
color 
White to Off-White
BRN 
1705262
LogP
-1.680 (est)
CAS DataBase Reference
353-09-3(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
AY3157500
HS Code 
29252900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G6878
Product name
3-Guanidinopropionic acid
Packaging
1g
Price
$71.6
Updated
2024/03/01
Sigma-Aldrich
Product number
G6878
Product name
3-Guanidinopropionic acid
Packaging
5g
Price
$264
Updated
2024/03/01
Cayman Chemical
Product number
16725
Product name
3-Guanidinopropionic Acid
Purity
≥98%
Packaging
1g
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
16725
Product name
3-Guanidinopropionic Acid
Purity
≥98%
Packaging
5g
Price
$178
Updated
2024/03/01
Cayman Chemical
Product number
16725
Product name
3-Guanidinopropionic Acid
Purity
≥98%
Packaging
500mg
Price
$32
Updated
2024/03/01
More
Less

3-Guanidinopropionic acid Chemical Properties,Usage,Production

Description

Guanidinopropionic acid is a white crystal that dissolves in water and is a creatine analog. Guanidinopropionic acid is a kind of amino acid derivatives. It is an important chemical raw material and intermediate. It exists in the serum, brain, liver, kidney and urine of mammals. It can improve insulin sensitivity and selectively reduce Adipose tissue weight can treat and prevent metabolic disorders, hyperglycemia, hyperinsulinemia, insensitivity to blood insulin, hyperlipidemia, hyperamylase, obesity and other symptoms.

Chemical Properties

White solid

Uses

3-Guanidinopropionic Acid is an acidic guanidine derivative that has been shown to ameliorate hyperglycemia in animal models of noninsulin-dependent diabetes.

Definition

ChEBI: 3-guanidinopropanoic acid is a guanidine compound bearing an N-(2-carboxyethyl) substituent. It is a creatine analogue that has been found to decreases plasma glucose levels It has a role as a hypoglycemic agent. It derives from a propionic acid. It is a tautomer of a 3-guanidinopropanoic acid zwitterion.

Synthesis

Using thiourea |?-alanine as a raw material, guanidinopropionic acid is prepared by a two-step alkylation reaction of nucleophilic substituted amine, the content is greater than 99.0%, and the total yield is 76.2%. The process is low cost, mild conditions, and easy operation, simple and suitable for industrial production.

References

[1] winder w w, hardie d g. amp-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes[j]. american journal of physiology-endocrinology and metabolism, 1999, 277(1): e1-e10.
[2] chaturvedi, r. k.,adhihetty, p.,shukla, s., et al. impaired pgc-1α function in muscle in huntington’s disease. human molecular genetics 18(16), 3048-3065 (2009).
[3] larsen s d, connell m a, cudahy m m, et al. synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid antidiabetic agent[j]. journal of medicinal chemistry, 2001, 44(8): 1217-1230.
[4] meglasson m d, wilson j m, yu j h, et al. antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic kkay and c57bl6job/ob mice and increases glucose disappearance in rhesus monkeys[j]. journal of pharmacology and experimental therapeutics, 1993, 266(3): 1454-1462.

3-Guanidinopropionic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-Guanidinopropionic acid Suppliers

Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
More
Less

View Lastest Price from 3-Guanidinopropionic acid manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
beta-Guanidinopropionic acid 353-09-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-06
Hebei Chuanghai Biotechnology Co,.LTD
Product
3-Guanidinopropionic Acid 353-09-3
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-15
Hebei Mojin Biotechnology Co., Ltd
Product
beta-Guanidinopropionic acid 353-09-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-05

353-09-3, 3-Guanidinopropionic acidRelated Search:


  • b-Alanine, N-(aMinoiMinoMethyl)-
  • 3-guanidinopropanoicacid
  • guanidinepropanoicacid
  • guanidinopropionicacid
  • n-(aminoiminomethyl)-beta-alanin
  • n-(aminoiminomethyl)beta-alanine
  • 3-(diaminomethylideneamino)propanoic acid
  • 3-[bis(azanyl)methylideneamino]propanoic acid
  • GUANIDINOPROPIONIC ACID(P)
  • .beta.-Alanine, N-(aminoiminomethyl)-
  • beta-Guanidinopropio
  • 3-Guanidino Propionic
  • n-amidino-beta-alanin
  • N-(AMINOMETHYL)-BETA-ALANINE
  • 3-Guanidinopropanoate
  • 3-GUANIDINOPROPIONIC ACID
  • DL-BETA-GUANIDINO PROPIONIC ACID
  • GUANIDINO PROPANOIC ACID
  • BETA-GUANADINOPROPIONIC ACID
  • BETA-GUANIDINOPROPIONIC ACID
  • Β-GUANIDINOPROIONIC ACID 99% BIOTECH GRADE
  • GuanidinoPropionicAcid(Gpa)
  • Gpa (B–Guanidinopropionic Acid)
  • B-GUANIDINO PROPIONIC ACID
  • Guanidine propionate
  • BCGUANIDINOPROPIONIC ACID
  • Guanidion Propionic Acid
  • 3-Guanidinopropionic acid ,99%
  • Gpa(BuanidinopropionicAcid)
  • N-(Aminoiminomethyl)-β-alanine
  • PNU-10483
  • Guanidino Propionic Acid (3-Guanidino Propionic Acid)
  • β-Alanine, N-(aminoiminomethyl)-
  • 3-guanidinopropanoicaci
  • N-Carbamimidoyl-beta-alanine
  • β-Guanidinopropionic acid
  • RGX-202
  • Ompenaclid
  • 353-09-3
  • HNCNH2NHCH2CH2COOH
  • C4H9N3O2
  • AMINE
  • BioChemical
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • Arginine Derivatives
  • Unnatural Amino Acid Derivatives
  • Specialty Synthesis
  • Modified Amino Acids
  • Peptide Synthesis
  • A - H