3-Guanidinopropionic acid
- Product Name
- 3-Guanidinopropionic acid
- CAS No.
- 353-09-3
- Chemical Name
- 3-Guanidinopropionic acid
- Synonyms
- β-Guanidinopropionic acid;3-GUANIDINOPROPIONIC ACID;3-Guanidinopropanoate;3-guanidinopropanoicacid;RGX-202;PNU-10483;Ompenaclid;beta-Guanidinopropio;Guanidine propionate;3-Guanidino Propionic
- CBNumber
- CB4749112
- Molecular Formula
- C4H9N3O2
- Formula Weight
- 131.13
- MOL File
- 353-09-3.mol
3-Guanidinopropionic acid Property
- Melting point:
- 222 °C (dec.)(lit.)
- Boiling point:
- 299.1±42.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Aqueous Acid (Slightly), Water (Slightly, Heated)
- form
- Solid
- pka
- 4.22±0.10(Predicted)
- color
- White to Off-White
- BRN
- 1705262
- LogP
- -1.680 (est)
- CAS DataBase Reference
- 353-09-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- G6878
- Product name
- 3-Guanidinopropionic acid
- Packaging
- 1g
- Price
- $71.6
- Updated
- 2024/03/01
- Product number
- G6878
- Product name
- 3-Guanidinopropionic acid
- Packaging
- 5g
- Price
- $264
- Updated
- 2024/03/01
- Product number
- 16725
- Product name
- 3-Guanidinopropionic Acid
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 16725
- Product name
- 3-Guanidinopropionic Acid
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $178
- Updated
- 2024/03/01
- Product number
- 16725
- Product name
- 3-Guanidinopropionic Acid
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $32
- Updated
- 2024/03/01
3-Guanidinopropionic acid Chemical Properties,Usage,Production
Description
Guanidinopropionic acid is a white crystal that dissolves in water and is a creatine analog. Guanidinopropionic acid is a kind of amino acid derivatives. It is an important chemical raw material and intermediate. It exists in the serum, brain, liver, kidney and urine of mammals. It can improve insulin sensitivity and selectively reduce Adipose tissue weight can treat and prevent metabolic disorders, hyperglycemia, hyperinsulinemia, insensitivity to blood insulin, hyperlipidemia, hyperamylase, obesity and other symptoms.
Chemical Properties
White solid
Uses
3-Guanidinopropionic Acid is an acidic guanidine derivative that has been shown to ameliorate hyperglycemia in animal models of noninsulin-dependent diabetes.
Definition
ChEBI: 3-guanidinopropanoic acid is a guanidine compound bearing an N-(2-carboxyethyl) substituent. It is a creatine analogue that has been found to decreases plasma glucose levels It has a role as a hypoglycemic agent. It derives from a propionic acid. It is a tautomer of a 3-guanidinopropanoic acid zwitterion.
Synthesis
Using thiourea |?-alanine as a raw material, guanidinopropionic acid is prepared by a two-step alkylation reaction of nucleophilic substituted amine, the content is greater than 99.0%, and the total yield is 76.2%. The process is low cost, mild conditions, and easy operation, simple and suitable for industrial production.
References
[1] winder w w, hardie d g. amp-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes[j]. american journal of physiology-endocrinology and metabolism, 1999, 277(1): e1-e10.
[2] chaturvedi, r. k.,adhihetty, p.,shukla, s., et al. impaired pgc-1α function in muscle in huntington’s disease. human molecular genetics 18(16), 3048-3065 (2009).
[3] larsen s d, connell m a, cudahy m m, et al. synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid antidiabetic agent[j]. journal of medicinal chemistry, 2001, 44(8): 1217-1230.
[4] meglasson m d, wilson j m, yu j h, et al. antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic kkay and c57bl6job/ob mice and increases glucose disappearance in rhesus monkeys[j]. journal of pharmacology and experimental therapeutics, 1993, 266(3): 1454-1462.
3-Guanidinopropionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Guanidinopropionic acid manufacturers
- Product
- beta-Guanidinopropionic acid 353-09-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-05
- Product
- 3-Guanidinopropionic Acid 353-09-3
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2023-05-15
- Product
- beta-Guanidinopropionic acid 353-09-3
- Price
- US $10.00/PCS
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-03-12