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Phenibut

Product Name
Phenibut
CAS No.
1078-21-3
Chemical Name
Phenibut
Synonyms
Phenibut HCL;4-AMINO-3-PHENYLBUTYRIC ACID HCL;4-AMINO-3-PHENYLBUTANOIC ACID HYDROCHLORIDE;FENIBUT;Phenybut;Phenibut Powder;fenigam;phenylgam;Aminophenylbutyric acid;4-AMINO-3-PHENYLBUTIRIC ACID
CBNumber
CB2316925
Molecular Formula
C10H13NO2
Formula Weight
179.22
MOL File
1078-21-3.mol
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Phenibut Property

Melting point:
252.5°C (rough estimate)
Boiling point:
311.75°C (rough estimate)
Density 
1.1248 (rough estimate)
refractive index 
1.5710 (estimate)
solubility 
Free base: 35 mg/mL in DMSO (195.29 mM) at 25 °C (SellekChem, 2019).Hydrochloride salt (Cayman, 2016): 25 mg/ml in DMF; 20 mg/ml in DMSO; 14 mg/ml in ethanol; 10 mg/mL in PBS (pH 7.2).
pka
4.10±0.10(Predicted)
form 
solid
color 
White
InChI
InChI=1S/C10H13NO2/c11-7-9(6-10(12)13)8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13)
InChIKey
DAFOCGYVTAOKAJ-UHFFFAOYSA-N
SMILES
C(O)(=O)CC(C1=CC=CC=C1)CN
CAS DataBase Reference
1078-21-3(CAS DataBase Reference)
EPA Substance Registry System
Benzenepropanoic acid, .beta.-(aminomethyl)- (1078-21-3)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2922498590
Toxicity
TDLo orl-hmn: 5 mg/kg:CNS BEXBAN 57,52,64
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A630595
Product name
4-Amino-3-phenylbutanoicAcid
Packaging
10g
Price
$65
Updated
2021/12/16
TRC
Product number
A630595
Product name
4-Amino-3-phenylbutanoicAcid
Packaging
1g
Price
$40
Updated
2021/12/16
AK Scientific
Product number
0709BA
Product name
4-Amino-3-phenylbutanoicacid
Packaging
5g
Price
$398
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA130469
Product name
4-Amino-3-phenylbutanoic acid hydrochloride
Packaging
5G
Price
$436
Updated
2021/12/16
Matrix Scientific
Product number
008053
Product name
4-Amino-3-phenyl-butyric acid hydrochloride
Packaging
1g
Price
$72
Updated
2021/12/16
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Phenibut Chemical Properties,Usage,Production

Description

Phenibut, also known as fenibut, phenigamma, and beta-phenyl-gamma-aminobutyric acid, is a derivative of the neurotransmitter GABA. It was developed in Russia,and there it has been used clinically since the 1960s to treat anxiety and related conditions,including insomnia(Lapin,2001). Phenibut has anxiolytic properties and is commonlycompared to benzodiazepines and baclofen.Structurally,phenibut issimilar to GABA, with the addition of the phenyl ring. This allows thecompound to more easily cross the blood-brain barrier, but also changesits activity profile (Shulgina,1986). Scientific studies demonstrate that phenibut can be safely used to treat anxiety, depression,epilepsy, speech disorders, and insomnia.

Uses

4-amino-3-phenylbutanoic acid (cas# 1078-21-3) is a GABAA receptor agonist, used for treatment of disorders influenced by dysfunction of pancreatic β cells and also used in combination with other agents.

Preparation

Phenibut was synthesized by Perekalin and his associates at the Department of Organic Chemistry of the Herzen Pedagogic Institute in St. Petersburg, the Russian Federation. In initial publications phenibut was known as phenigamma (Lapin, 2001, V. V. Perekalin, 1954).
Fenibut synthesis: from benzoyl chloride and ethyl acetoacetate as raw materials, through condensation and hydrolysis of ethyl benzoyl acetate, and then condensation of benzaldehyde and nitromethane to generate trans-nitrostyrene, and then the two are combined. Micheal addition, the adduct is then catalytically hydrogenated with Raney nickel, and finally hydrolyzed in concentrated hydrochloric acid to produce phenibate.

Synthesis of Phenibut (16) and Baclofen (17).

Application

Phenibut is an anxiolytic and nootropic drug, discovered in the Soviet Union used to treat several psychiatric disorders. It can be used in the treatment of anxiety, depression, asthenia, post-traumatic stress disorder, stuttering, and vestibular disorders.

Definition

ChEBI: Phenibut is an organonitrogen compound and an organooxygen compound. It is functionally related to a gamma-amino acid.

Side effects

When taken by mouth: Phenibut is likely unsafe. Phenibut can cause many side effects, including reduced consciousness, dizziness, nausea, poor balance, and fatigue. Taking large doses can cause trouble breathing, unconsciousness, and death.
Phenibut can cause dependence. People who use phenibut for 3 days or more and then stop taking it might experience withdrawal symptoms. These symptoms can include decreased appetite, nausea, muscle aches, fast heart rate, anxiety, agitation, trouble sleeping, and seizures.

Safety Profile

Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: somnolence, hallucinations, distorted perception. Used as a mood elevator and tranquilizer. When heated to decomposition it emits toxic fumes of NOx.

Drug interactions

Pregabalin (Lyrica) interacts with Phenibut: Phenibut acts on the brain in a similar way to pregabalin. Taking these two chemicals together might increase the risk for side effects.
Sedative medications (CNS depressants) interacts with Phenibut: Phenibut might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking phenibut with sedative medications might cause breathing problems and/or too much sleepiness.

Regulatory Status

USA - Phenibut is still an uncontrolled substance in the United States, and it is legal to sell and possess phenibut. It has not been approved for clinical use in the United States.
Europe - Unscheduled. It is not regulated by the European Medicines Agency. However, some nootropic substances such as piracetam are available only on prescription in some European Union countries and are freely available in others.
Russia - Phenibut is a licensed prescription medication used for a variety of conditions including anxiety, insomnia, post-traumatic stress disorders, depression, stuttering, tics, attention deficit disorders, and vestibular disorders. Russian cosmonauts were reported to have been supplied with the substance to help relieve tension, anxiety and fear (Buckley 2006).

Phenibut Preparation Products And Raw materials

Raw materials

Preparation Products

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Phenibut Suppliers

Xi'an Lyna Bio-Tech Co., Ltd.
Tel
029-84161958 18629577295
Fax
029-84161958
Email
magic@lynabio.com
Country
China
ProdList
1062
Advantage
55
Shanghai Norky Pharmaceutical Co., Ltd.
Tel
021-021-61075308 15216782696
Fax
021-61075308
Email
sales@norkysh.com
Country
China
ProdList
65
Advantage
58
Wuhan Senwayer Century Chemical Co.,Ltd
Tel
027-86652399 13627115097;
Fax
86-27-59707018
Email
sales@senwayer.com
Country
China
ProdList
267
Advantage
55
HANGZHOU LOOP BIOTECH CO., LTD.
Tel
057185260761 13396556070
Email
sales@looppharm.com
Country
China
ProdList
54
Advantage
58
Wuhan Yida Pharmaceutical Co., Ltd
Tel
+86-13401188533 +86-13476102740
Email
3451936732@qq.com
Country
China
ProdList
23
Advantage
58
Xi 'an Jiuqi Biotechnology Co., LTD
Tel
029-13186100227 13186100227
Email
3147904319@qq.com
Country
China
ProdList
89
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
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View Lastest Price from Phenibut manufacturers

Dorne Chemical Technology co. LTD
Product
4-Amino-3-phenylbutanoic acid 1078-21-3
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
Shaanxi Xianhe Biotech Co., Ltd
Product
Phenibut hcl(4-Amino-3-(4-fluorophenyl)butyric acid hydrochloride) 1078-21-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000 kg
Release date
2024-08-14
Guangdong Junhua Chemical Co., Ltd
Product
Finibaut 1078-21-3
Price
US $290.00-160.00/kg
Min. Order
1kg
Purity
99%pure
Supply Ability
10 tons
Release date
2024-12-11

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