2-Amino-6-chlorobenzoic acid
- Product Name
- 2-Amino-6-chlorobenzoic acid
- CAS No.
- 2148-56-3
- Chemical Name
- 2-Amino-6-chlorobenzoic acid
- Synonyms
- LAQU-001;RARECHEM AL BO 1514;TIMTEC-BB SBB001735;2-Amino-6-chlorobenz;6-chloro-2-aMino acid;6-CHLOROANTHRANILIC ACID;AMino-6-chlorobenzoic acid;6-AMINO-2-CHLOROBENZOC ACID;2-choro-6-Aminobenzoic Acid;2 mino-6-chlorobenzoic acid
- CBNumber
- CB4752611
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 2148-56-3.mol
2-Amino-6-chlorobenzoic acid Property
- Melting point:
- 158-160 °C (lit.)
- Boiling point:
- 250°C (rough estimate)
- Density
- 1.3246 (rough estimate)
- refractive index
- 1.5560 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 0.97±0.10(Predicted)
- form
- Crystalline Powder
- color
- Light yellow to beige
- Water Solubility
- Very soluble in water. Soluble in methanol.
- BRN
- 2804041
- InChI
- InChI=1S/C7H6ClNO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,9H2,(H,10,11)
- InChIKey
- SZCPTRGBOVXVCA-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=C(Cl)C=CC=C1N
- CAS DataBase Reference
- 2148-56-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Amino-6-chlorobenzoic acid(2148-56-3)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 422622
- Product name
- 2-Amino-6-chlorobenzoic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $31.2
- Updated
- 2023/06/20
- Product number
- 422622
- Product name
- 2-Amino-6-chlorobenzoic acid
- Purity
- 98%
- Packaging
- 10g
- Price
- $59.5
- Updated
- 2023/06/20
- Product number
- C2048
- Product name
- 6-Chloroanthranilic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $22
- Updated
- 2025/07/31
- Product number
- C2048
- Product name
- 6-Chloroanthranilic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $66
- Updated
- 2025/07/31
- Product number
- A617660
- Product name
- 2-Amino-6-chlorobenzoic acid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
2-Amino-6-chlorobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
2-Amino-6-chlorobenzoic acid is used as intermediate for medicine.
Application
The tricyclohexyltin 2-amino-6-chlorobenzoate was synthesized by the reaction of the tricyclohexyltin hydroxide with the 2-amino-6-chlorobenzoic acid.
Preparation
A, in the reaction vessel being provided with agitator, thermometer, reflux condenser, Dropping funnel, add cerium chloride 0.16mol, 4-hydroxy 3-methoxybenzene ethanol solution 0.19mol, Klorvess Liquid 400-500ml, control mixing speed and exist 160-190rpm, rising solution temperature, to 60-65°C, is slowly added to 2-chloro-6-nitrobenzoyl acid solution 0.13mol, sulfurous acid Hydrogen potassium solution 200ml, raises mixing speed to 260-310rpm, back flow reaction 5-7h；
B, reduction solution temperature, to 15-19°C, separate out solid, filter, and add diammonium hydrogen citrate solution 150-in filtrate 180ml, concentrating under reduced pressure, separate out solid, filter, dehydrant is dehydrated, brine, and pyridine solution washs, ethyl acetate solution Middle recrystallization, obtains crystal 2-amino-6-chlorobenzoic acid (C7H6ClNO2).
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
6575-11-7
2148-56-3
In a 250 mL round-bottomed flask, 5 g (32.77 mmol, 1.0 eq.) of 2-amino-6-chlorobenzonitrile was dissolved in 50 mL of a 30% aqueous potassium hydroxide (KOH) solution, followed by the addition of 3 mL of hydrogen peroxide (H2O2). The mixture was reacted under reflux conditions overnight. Upon completion of the reaction, the reaction mixture was washed sequentially with ether and dichloromethane each, followed by acidification. The acidified mixture was extracted with dichloromethane and ethyl acetate, and after separating the organic layer, the organic layer was washed with saturated brine. The organic layer was dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure to give 5.31 g (30.95 mmol, 94% yield) of 2-amino-6-chlorobenzoic acid as an orange solid.
References
[1] Patent: KR2017/74380, 2017, A. Location in patent: Paragraph 0175-0178
[2] Patent: US2018/105527, 2018, A1. Location in patent: Paragraph 0439-0441
2-Amino-6-chlorobenzoic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Amino-6-chlorobenzoic acid manufacturers
- Product
- 2-amino-6-chlorobenzoic acid 2148-56-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-08-22
- Product
- 2-Amino-6-chlorobenzoic acid 2148-56-3
- Price
- US $10.00-8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-06
- Product
- 2-Amino-6-chlorobenzoic acid 2148-56-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-24