ChemicalBook > CAS DataBase List > 2-CHLORO-5-FLUOROANISOLE

2-CHLORO-5-FLUOROANISOLE

Product Name
2-CHLORO-5-FLUOROANISOLE
CAS No.
450-89-5
Chemical Name
2-CHLORO-5-FLUOROANISOLE
Synonyms
2-Chloro-5-flouroanisole;2-CHLORO-5-FLUOROANISOLE;2-Chloro-5-fluoroanisole98%;2-Chloro-5-fluoroanisole >2-Chloro-5-fluoroanisole,97%;2-Chloro-5-fluoroanisole 98%;1-CHLORO-4-FLUORO-2-METHOXYBENZENE;1-Chloro-2-methoxy-4-fluorobenzene;Benzene, 1-chloro-4-fluoro-2-methoxy-;2-CHLORO-5-FLUOROANISOLE ISO 9001:2015 REACH
CBNumber
CB4753153
Molecular Formula
C7H6ClFO
Formula Weight
160.57
MOL File
450-89-5.mol
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2-CHLORO-5-FLUOROANISOLE Property

Boiling point:
195 °C / 757mmHg
Density 
1.28
refractive index 
1.519
storage temp. 
Sealed in dry,Room Temperature
form 
Liquid
color 
Clear colorless
CAS DataBase Reference
450-89-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
10-36/37/38-36/38
Safety Statements 
16-26-36-37/39-35-28-15-3/9
RIDADR 
1993
Hazard Note 
Irritant
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2216
Product name
2-Chloro-5-fluoroanisole
Purity
>97.0%(GC)
Packaging
5g
Price
$65
Updated
2025/07/31
TRC
Product number
C585860
Product name
2-Chloro-5-fluoroanisole
Packaging
50mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC33586
Product name
2-Chloro-5-fluoroanisole
Packaging
50g
Price
$350
Updated
2021/12/16
AK Scientific
Product number
X4245
Product name
2-Chloro-5-fluoroanisole
Packaging
25g
Price
$167
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC33586
Product name
2-Chloro-5-fluoroanisole
Packaging
25g
Price
$220
Updated
2021/12/16
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2-CHLORO-5-FLUOROANISOLE Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Synthesis

3827-49-4

74-88-4

450-89-5

To a solution of 2-chloro-5-fluorophenol (959 mg, 6.54 mmol) in N,N-dimethylformamide (DMF, 15 mL) was added 60% sodium hydride (NaH, 496 mg, 12.4 mmol) in batches at 0 °C. After the hydrogen bubbling stopped, iodomethane (0.43 mL, 6.91 mmol) was added and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was slowly poured into a beaker containing water and crushed ice, alkalized with saturated aqueous sodium bicarbonate (NaHCO3) and extracted with dichloromethane (DCM). The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using hexane:ethyl acetate (9:1) as eluent to afford 1-chloro-4-fluoro-2-methoxybenzene (600 mg) as a colorless oil. High performance liquid chromatography (HPLC, 254 nm) retention time (Rt): 6.15 min. 1H nuclear magnetic resonance (NMR, 600 MHz, DMSO-d6) δ ppm: 3.86 (s, 3H), 6.76-6.85 (m, 1H), 7.10 (dd, J = 10.90, 2.84 Hz, 1H), 7.45 (dd, J = 8.70, 6.14 Hz, 1H).

References

[1] Patent: WO2017/220477, 2017, A1. Location in patent: Page/Page column 33

2-CHLORO-5-FLUOROANISOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-FLUOROANISOLE Suppliers

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View Lastest Price from 2-CHLORO-5-FLUOROANISOLE manufacturers

Career Henan Chemical Co
Product
2-CHLORO-5-FLUOROANISOLE 450-89-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-09

450-89-5, 2-CHLORO-5-FLUOROANISOLERelated Search:


  • 1-CHLORO-4-FLUORO-2-METHOXYBENZENE
  • 2-CHLORO-5-FLUOROANISOLE
  • 2-Chloro-5-fluoroanisole 98%
  • 2-Chloro-5-fluoroanisole98%
  • 1-Chloro-2-methoxy-4-fluorobenzene
  • 2-Chloro-5-fluoroanisole,97%
  • 2-Chloro-5-fluoroanisole1-Chloro-4-fluoro-2-methoxybenzene
  • 2-Chloro-5-flouroanisole
  • 1-Chloro-4-fluoro-2-methoxybenzene, 2-Chloro-5-fluorophenyl methyl ether
  • 2-Chloro-5-fluoroanisole &gt
  • Benzene, 1-chloro-4-fluoro-2-methoxy-
  • 2-CHLORO-5-FLUOROANISOLE ISO 9001:2015 REACH
  • 450-89-5
  • Anisole
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Chlorine Compounds
  • Fluorine Compounds