ChemicalBook > CAS DataBase List > 2-Phenoxyaniline

2-Phenoxyaniline

Product Name
2-Phenoxyaniline
CAS No.
2688-84-8
Chemical Name
2-Phenoxyaniline
Synonyms
Phenoxyaniline;2-Ade;NSC 39655;AKOS B020146;2-PhenoxyaniL;AURORA KA-7802;2-phenoxy-anilin;O-PHENOXYANILINE;2-PHENOXYANILINE;o-phenoxy-anilin
CBNumber
CB4754493
Molecular Formula
C12H11NO
Formula Weight
185.22
MOL File
2688-84-8.mol
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2-Phenoxyaniline Property

Melting point:
47-49 °C(lit.)
Boiling point:
170 °C18 mm Hg(lit.)
Density 
1.0936 (rough estimate)
refractive index 
1.5300 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Slightly soluble in chloroform and methanol.
pka
3.78±0.10(Predicted)
form 
Crystalline Powder or Flakes
color 
Brown to gray
BRN 
777766
Stability:
Hygroscopic
CAS DataBase Reference
2688-84-8(CAS DataBase Reference)
NIST Chemistry Reference
2-Aminodiphenyl ether(2688-84-8)
EPA Substance Registry System
o-Phenoxyaniline (2688-84-8)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38-22
Safety Statements 
26-37/39-36/37/39-36
RIDADR 
2811
WGK Germany 
3
RTECS 
BY7940000
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29222990
Toxicity
LD50 ivn-mus: 212 mg/kg TXCYAC 8,347,77
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
346683
Product name
2-Phenoxyaniline
Purity
99%
Packaging
25g
Price
$29
Updated
2025/07/31
Sigma-Aldrich
Product number
346683
Product name
2-Phenoxyaniline
Purity
99%
Packaging
500g
Price
$306.85
Updated
2025/07/31
TCI Chemical
Product number
A1142
Product name
2-Aminodiphenyl Ether
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
A1142
Product name
2-Aminodiphenyl Ether
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$297
Updated
2025/07/31
TRC
Product number
P298200
Product name
2-Phenoxylaniline
Packaging
25g
Price
$275
Updated
2021/12/16
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2-Phenoxyaniline Chemical Properties,Usage,Production

Chemical Properties

Whitetolightyellowcrystalpowde

Uses

2-Phenoxyaniline serves as an antiinflammatory agent that inhibits preferentially COX-2 over COX-1. It is used in the preparation of sodium primary amide complex, 4-methyl-2-(2-phenoxyphenyl)azo-phenol and 2-acetoaminodiphenyl ether. Further, it is used to form complexes with beta-cyclodextrin.

Uses

2-Phenoxyaniline may be used in the preparation of sodium primary amide complex, 2-PhOC6H4NHNa·NMe[(CH2)2NMe2]2. It was used in the preparation of 2-acetoaminodiphenyl ether. It may be used in the preparation of 4-methyl-2-(2-phenoxyphenyl)azo-phenol.

General Description

2-Phenoxyaniline forms crystalline 2:1 (host-to-guest) inclusion complexes with β-cyclodextrin.

Safety Profile

Poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx.

Synthesis

591-50-4

95-55-6

2688-84-8

General procedure: all reactions were carried out under air atmosphere. Iodobenzene (1.0 mmol), o-aminophenol (1.0 mmol), CuI (0.1 mmol), 1-(α-aminobenzyl)-2-naphthol (0.2 mmol), and K2CO3 (2.0 equiv.) were dissolved in 3 mL of DMSO, and the reaction was carried out for 24 hr at 120 °C. The reaction process was monitored by gas chromatography (GC). Upon completion of the reaction, the catalyst was removed by filtration and the product was extracted with ethyl acetate (EtOAc). The organic layers were combined and dried with anhydrous MgSO4 for 12 hours. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (10:1, v/v) to afford the target compound 2-aminodiphenyl ether.

References

[1] Synthetic Communications, 2014, vol. 44, # 17, p. 2468 - 2477
[2] Tetrahedron Letters, 2014, vol. 55, # 51, p. 7082 - 7088

2-Phenoxyaniline Preparation Products And Raw materials

Raw materials

Preparation Products

Triclosan
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View Lastest Price from 2-Phenoxyaniline manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Phenoxyaniline 2688-84-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98
Supply Ability
10000KGS
Release date
2025-12-05
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-Phenoxyaniline 2688-84-8
Price
US $65.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-06-06
Henan Fengda Chemical Co., Ltd
Product
2-Phenoxyaniline 2688-84-8
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-16

2688-84-8, 2-PhenoxyanilineRelated Search:

Phenylhydrazine PHENYL VALERATE Dimethyl ether C8E3 4,4'-Oxydiphthalic anhydride Triclosan 4,4'-Oxydianiline Ethylbenzene Diphenyl ether 4-Nitro-2-phenoxyaniline NiMesulide EP IMpurity E N-(Methylsulfonyl)-4'-nitro-2'-phenoxyMethanesulfonanilide (2-PHENOXY)METHYLSULFONYLANILINE 2-(p-tolyloxy)aniline 2-AMINO-4,4'-DICHLORODIPHENYL ETHER 5-Chloro-2-(2-chlorophenoxy)aniline Diethyl ether Phenoxazine

  • AURORA KA-7802
  • 2-AMINOPHENYL PHENYL ETHER
  • 2-AMINODIPHENYL ETHER
  • 2-PHENOXYANILINE
  • AKOS B020146
  • O-PHENOXYANILINE
  • 2-Ade
  • 2-phenoxy-anilin
  • 2-phenoxy-benzenamin
  • 2-phenoxybenzenamine
  • Aniline, 2-phenoxy-
  • Aniline, o-phenoxy-
  • Benzenamine, 2-phenoxy-
  • o-Aminophenyl phenyl ether
  • o-aminophenylphenylether
  • o-phenoxy-anilin
  • 2-Aminodiphenyl ether~2-Aminophenyl phenyl ether
  • Aminodiphenylether,97%
  • 2-Phonoxyaniline
  • 2-Phenoxyaniline,99%
  • 2-AMINODIPHENYLETHER(2-PHENOXYANILINE)
  • 2-AMINODIPHENYL ETHER 97+%
  • 2-Phenoxyaniline,98%
  • Ortho Phenoxy Aniline (2-Amino Diphenyl Ether)
  • 2-Aminophenyl Phenyl Ether 2-Phenoxyaniline
  • Phenoxyaniline
  • NiMesulide EP IMpurity C
  • Nimesulide Impurity 3(Nimesulide EP Impurity C)
  • Nimesulide impurity-C(EP/BP)
  • 2-Phenoxylaniline
  • 2-Aminodiphenyl Ether &gt
  • 2-PhenoxyaniL
  • Nimesulide EP Impurity C (2-phenoxyaniline)
  • 2-Phenoxyaniline/2-Aminodiphenyl Ether
  • 2-Amino-2’-Diphenyl Ether
  • Ortho Amino Di Phenyl Ether (2 PHENOXY ANILINE)
  • NIMESULIDE EP IMP C
  • NSC 39655
  • 2688-84-8
  • 2688-84-4
  • C12H11O2N
  • C11 to C37
  • Building Blocks
  • Amines
  • Organic Building Blocks
  • Nitrogen Compounds