ChemicalBook > CAS DataBase List > 1,4-Dihydroxynaphthalene

1,4-Dihydroxynaphthalene

Product Name
1,4-Dihydroxynaphthalene
CAS No.
571-60-8
Chemical Name
1,4-Dihydroxynaphthalene
Synonyms
NAPHTHALENE-1,4-DIOL;1,4-NAPHTHALENEDIOL;1,4-NDO;1.4-Dihydroxyn;1,4-naphthoquinol;1,4-NAPTHALENEDIOL;Hydronaphthoquinone;Naphthohydroquinone;Naphthalin-1,4-diol;P-NAPHTHOHYDROQUINONE
CBNumber
CB4756341
Molecular Formula
C10H8O2
Formula Weight
160.17
MOL File
571-60-8.mol
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1,4-Dihydroxynaphthalene Property

Melting point:
191-192 °C (dec.)
Boiling point:
246.06°C (rough estimate)
Density 
1.0924 (rough estimate)
refractive index 
1.5178 (estimate)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
crystals
pka
pK1:9.37;pK2:10.93 (26°C，μ=0.65)
color 
Grey
Water Solubility 
slightly soluble
BRN 
1307689
CAS DataBase Reference
571-60-8(CAS DataBase Reference)
NIST Chemistry Reference
1,4-Naphthalenediol(571-60-8)
EPA Substance Registry System
1,4-Naphthalenediol (571-60-8)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
22-37/38-41-43-36/37/38-25
Safety Statements 
26-39-45-36/37/39-28A-24
WGK Germany 
3
RTECS 
QJ4730000
F 
8-10-16-23
HS Code 
2921450090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
70430
Product name
1,4-Dihydroxynaphthalene
Purity
technical, ≥90% (HPLC)
Packaging
10g
Price
$162
Updated
2025/07/31
TCI Chemical
Product number
D0589
Product name
1,4-Dihydroxynaphthalene
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$111
Updated
2025/07/31
TCI Chemical
Product number
D0589
Product name
1,4-Dihydroxynaphthalene
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$334
Updated
2025/07/31
TRC
Product number
D447150
Product name
1,4-Dihydroxynaphthalene
Packaging
1g
Price
$95
Updated
2021/12/16
Usbiological
Product number
411334
Product name
1,4-Dihydroxynaphthalene
Packaging
1g
Price
$355
Updated
2021/12/16
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1,4-Dihydroxynaphthalene Chemical Properties,Usage,Production

Chemical Properties

brown to greyish powder. 1,4-Naphthalenediol [571-60-8], mp 195℃, is synthesized by reduction of 1,4- naphthoquinone with sodium dithionite, or by hydrolysis of 4-amino-1-naphthol with 20 % sulfuric acid. It undergoes oxidation to give 1,4-naphthoquinone; amination to give 4-amino-1-naphthol; and methylation (MeOH – HCl) to give 4-methoxy-1-naphthol.

Uses

1,4-Dihydroxynaphthalene is frequently used in organic synthesis as a reagent. In particular, it is used in the synthesis of a pH independent and cell permeant fluorescent dye, a hydroxyl regioisomeric 3'',4''-benzorhodol, which can be used as a fluorescent chemosensor and biomarker for biological applications.

Definition

ChEBI: Naphthalene-1,4-diol is a naphthalenediol and a naphthohydroquinone.

Biological Activity

1,4-Dihydroxynaphthalene is a potent HSV-1 protease inhibitor with inhibitory effects on the HCMV protease, which can be used to study herpesviruses.

References

[1] LAURIE S. TSURUDA   A. D J  Michael W Lamé. Formation of epoxide and quinone protein adducts in B6C3F1 mice treated with naphthalene, sulfate conjugate of 1,4-dihydroxynaphthalene and 1,4-naphthoquinone[J]. Archives of Toxicology, 1995, 69 6: 362-367. DOI:10.1007/s002040050185.

1,4-Dihydroxynaphthalene Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-Dihydroxynaphthalene Suppliers

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View Lastest Price from 1,4-Dihydroxynaphthalene manufacturers

Henan Fengda Chemical Co., Ltd
Product
1,4-Dihydroxynaphthalene 571-60-8
Price
US $10.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-28
Career Henan Chemical Co
Product
1,4-Dihydroxynaphthalene 571-60-8
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2019-12-31

571-60-8, 1,4-DihydroxynaphthaleneRelated Search:

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  • 1,4-NAPHTHOHYDROQUINONE
  • 1,4-NAPTHALENEDIOL
  • P-NAPHTHOHYDROQUINONE
  • NAPHTHALENE-1,4-DIOL
  • 1,4-DIHYDROXYNAPHTHALENE
  • 1,4-NDO
  • 1,4-NAPHTHALENEDIOL
  • 1,4-Dihydroxynaphthalene, 95+%
  • ALPHA-NAPHTHOHYDROQUINONE
  • 1,4-dihydroxynaphthalene,1:1mixturewith1,4-naphthoquinone
  • 1,4-naphthoquinol
  • 1,4-Naphththalenediol
  • alpha-naphthoquinhydrone
  • Hydronaphthoquinone
  • Naphthalenediol-(1,4)
  • Naphthohydroquinone
  • 1,4-DIHYDROXYNAPTHALENE
  • 1,4-Naphthalenediol, p-Naphthohydroquinone (α)
  • 1,4-Dihydroxynaphthalene, balance mainly 1,4-Naphthoquinone,92%
  • 1,4-Dihydroxynaphthalene, balance mainly 1,4-Naphthoquinone, 92%
  • Naphthalene-1,4-diol, 95%+
  • 1,4-Naphthalenediol alpha-Naphthohydroquinone
  • 1.4-Dihydroxyn
  • 1,4-Dihydroxynaphthalene, technical
  • 1,4-Dihydroxynaphthalene &gt
  • Naphthalin-1,4-diol
  • Bifeprunox Impurity 10
  • 571-60-8
  • Oxygen Compounds
  • Polyols
  • Organic Building Blocks
  • Building Blocks
  • Naphthalene derivatives
  • Intermediates of Dyes and Pigments