ChemicalBook > CAS DataBase List > TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE

TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE

Product Name: TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
CAS No.: 635698-56-5
Chemical Name: TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
Synonyms: 6-Boc-2,4-Dichloro-5,6,7,...;6-Boc-2,4-Cl2-5,7,8-H3-pyrido[4,3-d]pyrimidine;6-Boc-2,4-dichloro-7,8-dihydro-(5H)-pyrido[4,3-d]pyrimidine;6-Boc-2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidine;2,4-Dichloro-,5,6,7,8-tetrahydro-6-Boc-Pyrido[4,3-d]pyrimidine;tert-butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6...;Pyrido[4.3-d]pyriMidine-6(5H)-carboxylicacid. 2.4-dichloro-7.8-d;tert-Butyl 2,4-dichloro-5H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate;ert-butyl 2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate;tert-butyl 2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyriMidine-6-carboxylate
CBNumber: CB4757308
Molecular Formula: C12H15Cl2N3O2
Formula Weight: 304.17
MOL File: 635698-56-5.mol

Less

TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE Property

Boiling point:: 423.1±45.0 °C(Predicted)
Density: 1.352±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.98±0.20(Predicted)
Appearance: White to off-white Solid

Less

Safety

HazardClass: IRRITANT

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: B807123
Product name: tert-Butyl2,4-Dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
Packaging: 500mg
Price: $175
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141010
Product name: tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
Packaging: 50mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141010
Product name: tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
Packaging: 100mg
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141010
Product name: tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
Packaging: 250mg
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141010
Product name: tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Less

TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE Chemical Properties,Usage,Production

Uses

tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate is a tert-butyl ester compound used in the synthesis of tetrahydropyrimidine derivatives as AHR modulators.

Synthesis

726697-13-8

24424-99-5

635698-56-5

2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (270 mg, 1.33 mmol) and di-tert-butyl dicarbonate (348 mg, 1.6 mmol) were used as the starting material, and 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine was dissolved in dichloromethane (30 mL) at 0 °C. Triethylamine (200 mg, 2.0 mmol) was then added and the reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the organic layer was separated by diluting the reaction mixture with dichloromethane (30 mL) and water (30 mL). The aqueous phase was further extracted with dichloromethane (30 mL x 2). All organic layers were combined, washed with brine and dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the solvent was removed by concentration under reduced pressure. The resulting crude product was purified by fast column chromatography using a solvent mixture of hexane and ethyl acetate to afford N-BOC-2,4-dichloro-5,7,8-trihydropyrido[4,3-D]pyrimidine (300 mg, 74% yield). Mass spectrometry analysis (LRMS, M+H+): calculated value 305.17; measured value 305.24.

References

[1] Patent: WO2014/15291, 2014, A1. Location in patent: Page/Page column 172; 173
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9480 - 9497

TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE Suppliers

China 126 China Hong Kong 1 Germany 1 India 1 United Kingdom 1 United States 11 Global 141

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shangchem Co., Ltd.

Tel: +86-21-68182121
Fax: +86-21-68182121
Country: China
ProdList: 882
Advantage: 52

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

skychemical Co.Ltd

Tel: 021-20958197 20965099
Fax: 021-20960837
Email: sales@skychemical.com
Country: China
ProdList: 1183
Advantage: 57

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

China Kouting Group Limited

Tel: +86 (21) 5811-6473 5811-6475
Fax: +86 (21) 6129-4103
Email: sales@koutingchina.com
Country: China
ProdList: 496
Advantage: 60

Bsisun HK Imoprt And Export Company Limited

Tel: +86-18068513926
Fax: 0086-519-85153711
Country: China
ProdList: 1277
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

Aloespharm Co., Ltd.

Tel: 021-20960837
Fax: 021-20960837
Email: market@aloespharm.com
Country: China
ProdList: 1302
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

Shanghai Aspire Biological Technology Co., Ltd.

Tel: 021-61317773/021-31606483/2934163037
Fax: 021-61317773-604
Email: sales@aspirebio.com
Country: China
ProdList: 257
Advantage: 58

Modachem Shanghai Co., Ltd

Tel: +86 (0)21 51320687 51371369 1744605818
Fax: +86 (0)21 51371369
Country: China
ProdList: 1578
Advantage: 58

Jiaxing Novartis Chemical Co., Ltd.

Tel: 18957373295
Fax: -
Country: China
ProdList: 1580
Advantage: 58

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Sichuan Argalbio Technology Co,.Ltd

Tel: 028-028-60651388 13330964498
Email: slyu@hengkangtech.com
Country: China
ProdList: 378
Advantage: 58

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Ningbo Materials-X Co., Ltd

Tel: 0574-87487840-805 15888368997
Fax: 0574-87485342
Country: China
ProdList: 474
Advantage: 55

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q2635253576
Fax: QQ3382968513
Email: hailey@shsendpharm.com
Country: China
ProdList: 2081
Advantage: 55

skychemical Co.Ltd

Tel: 021-20960837,QQ1332204249
Fax: 021-20960837
Email: sales@skychemical.com
Country: China
ProdList: 3341
Advantage: 55

Nanjing Vital Chemical Co., Ltd.

Tel: 025-87193546 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 9021
Advantage: 60

Nanjing YaoCheng Pharmaceutical Co., Ltd.

Tel: 025-57043319 15261831516
Fax: 025-57043319
Email: 307514552@qq.com
Country: China
ProdList: 251
Advantage: 50

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
Country: China
ProdList: 5001
Advantage: 55

Shanghai Yunpun industrial Co.,Ltd

Tel: 21-61726900 15202122459
Fax: +86-21-60277507
Email: sales@yunpun.com
Country: China
ProdList: 494
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Huaxing Biological Technology Co., Ltd.

Tel: 18621295758
Fax: -QQ:1449085402
Email: 1449085402@qq.com
Country: China
ProdList: 1724
Advantage: 55

Nanjing KaiMubo Pharmaceutical Co., Ltd.

Tel: 025-66162170
Fax: 025-66162170
Country: China
ProdList: 7181
Advantage: 55

Suzhou Ruichi Pharmaceutical Technology Co., Ltd.

Tel: 0512-50152853
Fax: 0512-50152853
Email: jjks1111@126.com
Country: China
ProdList: 623
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

JinJin Le Chemical Co., Ltd

Tel: 18001959627(微信同号) 18001959627
Email: jjlchem2@163.com
Country: China
ProdList: 9981
Advantage: 58

Biokitchen

Tel: 021-021-021-31663258 13795219287
Fax: 021-31663258
Email: donghuanwen@126.com
Country: China
ProdList: 8816
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

Shanghai Benso Pharmaceutical Technology Co., Ltd.

Tel: 15088289376
Email: 248775804@qq.com
Country: China
ProdList: 4995
Advantage: 58

Shanghai SPAR pharmaceutical technology co., LTD

Tel: 021-000000 13917643586;
Email: admin@jingshipharmatech.com
Country: China
ProdList: 9856
Advantage: 58

Less

View Lastest Price from TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE 635698-56-5
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

635698-56-5, TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATERelated Search:

tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Pyrimidine, 2-chloro-4-ethyl- (9CI) 2,4-Dichloro-5-methylpyrimidine TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE 2-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Pyrido[4,3-d]pyrimidine, 4-chloro-5,6,7,8-tetrahydro- 2,4-Dichloro-6-methylpyrimidine

2,4-Dichloro-,5,6,7,8-tetrahydro-6-Boc-Pyrido[4,3-d]pyrimidine

Pyrido[4.3-d]pyriMidine-6(5H)-carboxylicacid. 2.4-dichloro-7.8-d

6-Boc-2,4-Dichloro-5,6,7,...

6-Boc-2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidine

tert-butyl 2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyriMidine-6-carboxylate

6-Boc-2,4-Cl2-5,7,8-H3-pyrido[4,3-d]pyrimidine

2,4-Dichloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid tert-butyl ester

tert-Butyl 2,4-dichloro-5H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate

TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE

ert-butyl 2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate

tert-butyl 2,4-dichloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate

tert-butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6...

TIANFUCHEM-- TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE

6-Boc-2,4-dichloro-7,8-dihydro-(5H)-pyrido[4,3-d]pyrimidine

635698-56-5

pyrimidine

Heterocycle-Pyrimidine series

CHIRAL CHEMICALS