2,4-Dichloro-6-methylpyrimidine
- Product Name
- 2,4-Dichloro-6-methylpyrimidine
- CAS No.
- 5424-21-5
- Chemical Name
- 2,4-Dichloro-6-methylpyrimidine
- Synonyms
- 6-Methyl-2,4-dichloropyriMidine;2,6-DICHLORO-4-METHYLPYRIMIDINE;NSC 13199;AKOS BBS-00005839;4-Dichloro-6-MethylpyriMidine;2,4-DICHLORO-6-METHYLPYRIMIDE;2,4-dichloro-6-methyl-pyrimidin;2,4-DICHLORO-6-METHYLPYRIMIDINE;2,4-Dichloro-6-methyl-1,3-diazine;2,4-Dichloro-6-methylpyrimidine>
- CBNumber
- CB8443434
- Molecular Formula
- C5H4Cl2N2
- Formula Weight
- 163
- MOL File
- 5424-21-5.mol
2,4-Dichloro-6-methylpyrimidine Property
- Melting point:
- 44-47 °C (lit.)
- Boiling point:
- 219 °C (lit.)
- Density
- 1.5462 (rough estimate)
- refractive index
- 1.6300 (estimate)
- Flash point:
- >230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Very Slightly, Heated, Sonicated), DMSO (Sparingly, Heated)
- form
- powder to crystal
- pka
- -2.12±0.30(Predicted)
- color
- White to Orange to Green
- Water Solubility
- Soluble in Chloroform, Ether, Ethyl Acetate and Toluene. Insoluble in water.
- BRN
- 114295
- InChI
- InChI=1S/C5H4Cl2N2/c1-3-2-4(6)9-5(7)8-3/h2H,1H3
- InChIKey
- BTLKROSJMNFSQZ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(C)=CC(Cl)=N1
- CAS DataBase Reference
- 5424-21-5(CAS DataBase Reference)
- EPA Substance Registry System
- Pyrimidine, 2,4-dichloro-6-methyl- (5424-21-5)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-27-36/37/39-45
- RIDADR
- UN 3263 8/PG 2
- WGK Germany
- 3
- Hazard Note
- Corrosive
- TSCA
- T
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 144185
- Product name
- 2,4-Dichloro-6-methylpyrimidine
- Purity
- 98%
- Packaging
- 25g
- Price
- $52.5
- Updated
- 2025/07/31
- Product number
- 144185
- Product name
- 2,4-Dichloro-6-methylpyrimidine
- Purity
- 98%
- Packaging
- 100g
- Price
- $165
- Updated
- 2025/07/31
- Product number
- D2958
- Product name
- 2,4-Dichloro-6-methylpyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- D2958
- Product name
- 2,4-Dichloro-6-methylpyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $176
- Updated
- 2025/07/31
- Product number
- D3531-31
- Product name
- 2,4-Dichloro-6-methylpyrimidine|
- Packaging
- 20g
- Price
- $418
- Updated
- 2021/12/16
2,4-Dichloro-6-methylpyrimidine Chemical Properties,Usage,Production
Chemical Properties
White to Light Yellow Powder
Uses
2,4-Dichloro-6-methylpyrimidine is used in the synthesis of (2-chloro-6-methyl-pyrimidin-4-yl)-(2,3-dihydro-benzothiazol-6-yl)-amine.
General Description
2,4-Dichloro-6-methylpyrimidine undergoes double cross-coupling reaction with 2-(tributylstannyl)pyridine, followed by aldol condensation to yield 4-arylvinyl-2,6-di(pyridin-2-yl)pyrimidines. It reacts with 1H,1H,2H,2H-perfluorodecanethiol during fluorous synthesis of disubstituted pyrimidines.
Synthesis
626-48-2
5424-21-5
Step 1. 2,4-Dichloro-6-methylpyrimidine (166-01) was prepared from 6-methylpyrimidine-2,4-diol (500 mg, 3.97 mmol) by reacting with phosphoryl chloride (4 mL) according to the literature procedure 49-01 to afford 540 mg of white solid product in 84% yield. Mass spectral analysis showed m/z: 164.7 [M + H]+.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 10, p. 1755 - 1757
[2] Molecules, 2012, vol. 17, # 4, p. 4533 - 4544
[3] Patent: WO2018/14802, 2018, A1. Location in patent: Paragraph 0472; 0473
[4] Organic and Biomolecular Chemistry, 2003, vol. 1, # 19, p. 3353 - 3361
[5] Journal of Heterocyclic Chemistry, 1987, vol. 24, # 1, p. 205 - 209
2,4-Dichloro-6-methylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloro-6-methylpyrimidine manufacturers
- Product
- 2,4-Dichloro-6-methylpyrimidine 5424-21-5
- Price
- US $100.00-50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-11-12
- Product
- 2,4-Dichloro-6-methylpyrimidine 5424-21-5
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-07