Methyl 2,4-dichloropyrimidine-6-carboxylate

Product Name: Methyl 2,4-dichloropyrimidine-6-carboxylate
CAS No.: 6299-85-0
Chemical Name: Methyl 2,4-dichloropyrimidine-6-carboxylate
Synonyms: Methyl 2,6-dichloropyrimidine-4-carboxylate;2,6-Dichloro-pyrimidine-4-carboxylic acid methyl ester;6-c;NSC45044;2-(3-CHLOROPHENYL)MALONDIALDEHYDE;2,6-dichloropyrimidine-4-carboxylate;2,4-dichloropyrimidine-6-carboxylate;2-(3-chlorophenyl)malondialdehyde,98%;2,4-Dichloro-6-(methoxycarbonyl)pyrimidine;Methyl 2,6-dichloropyrimidin-4-carboxylate
CBNumber: CB4326700
Molecular Formula: C6H4Cl2N2O2
Formula Weight: 207.01
MOL File: 6299-85-0.mol

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Methyl 2,4-dichloropyrimidine-6-carboxylate Property

Melting point:: 54-56
Boiling point:: 306 ºC
Density: 1.503
Flash point:: 139 ºC
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: White to off white to faint cream flakes
pka: -5.83±0.30(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C6H4Cl2N2O2/c1-12-5(11)3-2-4(7)10-6(8)9-3/h2H,1H3
InChIKey: DQNQNLWKAGZNIT-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(Cl)=CC(C(OC)=O)=N1

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: M301390
Product name: Methyl2,4-dichloropyrimidine-6-carboxylate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M301390
Product name: Methyl2,4-dichloropyrimidine-6-carboxylate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: J94908
Product name: Methyl2,4-Dichloro-pyrimidine-6-carboxylate
Packaging: 1g
Price: $10
Updated: 2021/12/16

Oakwood

Product number: 023426
Product name: Methyl2,4-dichloropyrimidine-6-carboxylate
Purity: 98%
Packaging: 1g
Price: $10
Updated: 2021/12/16

Oakwood

Product number: 023426
Product name: Methyl2,4-dichloropyrimidine-6-carboxylate
Purity: 98%
Packaging: 5g
Price: $25
Updated: 2021/12/16

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Methyl 2,4-dichloropyrimidine-6-carboxylate Chemical Properties,Usage,Production

Synthesis

To a stirred suspension of orotic acid (20.00 g, 128.140 mmol) in POCI3(75 ml) was added DMF (catalytic amount, -0.5 ml) at ambient temperature, and the resulting reaction mixture was refluxed for 3 h. Excess of POC was removed by vacuum distillation after 3h of reflux. The obtained slurry was poured slowly into a 5 per cent mixture of methanol in chloroform (200 ml) at 0°C and stirred for 30 min. The organic layer obtained was washed with a saturated solution of NaHCC>3 (3 x 200 ml). The combined organic phase was dried over Na2S04, filtered and concentrated under reduced pressure, yielding Methyl 2,4-dichloropyrimidine-6-carboxylate (19.00 g, 91 .800 mmol).

References

[1] Patent: WO2018/167276, 2018, A1. Location in patent: Paragraph 00131; 00132; 00133

Methyl 2,4-dichloropyrimidine-6-carboxylate Preparation Products And Raw materials

Raw materials

Heptane N,N-Dimethylformamide Sodium sulfate Phosphorus oxitrichloride Orotic acid Diethyl ether Benzene Methanol Thionyl chloride Activated carbon

Preparation Products

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Methyl 2,4-dichloropyrimidine-6-carboxylate Suppliers

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View Lastest Price from Methyl 2,4-dichloropyrimidine-6-carboxylate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-(3-CHLOROPHENYL)MALONDIALDEHYDE 6299-85-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

Shaanxi Dideu Medichem Co. Ltd

Product: 2,6-dichloropyrimidine-4-carboxylate 6299-85-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

Career Henan Chemical Co

Product: 2-(3-CHLOROPHENYL)MALONDIALDEHYDE 6299-85-0
Price: US $3500.00-3200.00/KG
Min. Order: 1KG
Purity: 97%
Supply Ability: 100kg
Release date: 2018-08-03

6299-85-0, Methyl 2,4-dichloropyrimidine-6-carboxylateRelated Search:

Sulfadiazine 2,4-Dichloropyrimidine 2-(4-CHLOROPHENYL)MALONDIALDEHYDE 95% 2-(4-CHLOROPHENYL)MALONDIALDEHYDE, 95,2-(2-Chlorophenyl)malondialdehyde 2-(4-CHLOROPHENYL)MALONDIALDEHYDE PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER 2-(3-CHLOROPHENYL)MALONDIALDEHYDE 2-Chloropyrimidine-4-carboxylic acid ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE 4-PYRIMIDINECARBOXALDEHYDE, 2,6-DICHLORO- METHYL 2,4-DICHLOROPYRIMIDINE-6-CARBOXYLATE 2,4-Dichloro-6-methylpyrimidine

2,6-DICHLORO-PYRIMIDINE-4-CARBOXYLIC ACID ETHYL ESTER

2,6-Dichloro-pyrimidine-4-carboxylic acid methyl ester

NSC45044

Methyl 2,4-dichloropyrimidine-6-carboxylate 99%

Methyl2,4-dichloropyrimidine-6-carboxylate99%

2-(3-CHLOROPHENYL)MALONDIALDEHYDE

4-Methyl-2-(3,4-dichlorophenyl)thiazole-5-carboxylicacid

Methyl 2,4-dichloropyrimidine-6-carboxylate

4-PyriMidinecarboxylicacid, 2,6-dichloro-, Methyl ester

2,4-Dichloro-6-(methoxycarbonyl)pyrimidine

Methyl 2,6-dichloropyrimidine-4-carboxylate

2,6-dichloropyrimidine-4-carboxylate

2,4-dichloropyrimidine-6-carboxylate

Tert-butyl n-(2-(4-nitrophenyl)ethyl)carbamate

6-c

2-(3-chlorophenyl)malondialdehyde,98%

Methyl 2,6-dichloropyrimidin-4-carboxylate

6299-85-0

6299-45-0

Heterocycle-Pyrimidine series

pharmacetical