2-Chloropyrimidine-4-carboxylic acid
- Product Name
- 2-Chloropyrimidine-4-carboxylic acid
- CAS No.
- 149849-92-3
- Chemical Name
- 2-Chloropyrimidine-4-carboxylic acid
- Synonyms
- AKOS BBS-00002507;CHEMBRDG-BB 4010944;4-Carboxy-2-chloropyrimidine;2-Chloropyrimidine-4-CarboxylicAci;2-Chloro-pyrimidin-4-carboxylic acid;2-Chloropyrimidine-4-carboxylic acid;4-Pyrimidinecarboxylic acid, 2-chloro-;4-Carboxy-2-chloropyrimidine, 4-Carboxy-2-chloro-1,3-diazine
- CBNumber
- CB6216292
- Molecular Formula
- C5H3ClN2O2
- Formula Weight
- 158.54
- MOL File
- 149849-92-3.mol
2-Chloropyrimidine-4-carboxylic acid Property
- Boiling point:
- 411.4±18.0 °C(Predicted)
- Density
- 1.579
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 2.44±0.10(Predicted)
- color
- Yellow
- InChI
- InChI=1S/C5H3ClN2O2/c6-5-7-2-1-3(8-5)4(9)10/h1-2H,(H,9,10)
- InChIKey
- YMDSUQSBJRDYLI-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(C(O)=O)=N1
- CAS DataBase Reference
- 149849-92-3(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 22-26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C428485
- Product name
- 2-Chloropyrimidine-4-carboxylicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FC32666
- Product name
- 2-Chloropyrimidine-4-carboxylic acid
- Packaging
- 2g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 070507
- Product name
- 2-Chloropyrimidine-4-carboxylic acid
- Purity
- 95%
- Packaging
- 5g
- Price
- $119
- Updated
- 2021/12/16
- Product number
- FC32666
- Product name
- 2-Chloropyrimidine-4-carboxylic acid
- Packaging
- 5G
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FC32666
- Product name
- 2-Chloropyrimidine-4-carboxylic acid
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
2-Chloropyrimidine-4-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
Yellow to light brown or brown solid
Uses
2-Chloropyrimidine-4-carboxylic acid is a pharmaceutical intermediate compound used in the preparation of oxazolopyrimidine ketoamides with high active antagonism against TRPA1. This class of drugs can be used in the treatment of pain, itching, inflammation, asthma, cough and other related conditions.
Synthesis
149849-93-4
149849-92-3
Example 5 Preparation of 2-chloropyrimidine-4-carboxamide: Ammonia was passed into 20 mL of tetrahydrofuran for 35 minutes at -6 °C. The reaction system was then warmed to 10 °C and 1.5 g (8.47 mmol) of 2-chloropyrimidine-4-carbonyl chloride was added. The reaction solution was stirred at room temperature for 45 min. Upon completion of the reaction, the reaction solution was concentrated using a rotary evaporator and the residue was poured into 90 mL of saturated NaHCO3 solution. The aqueous phase was extracted three times with 50 mL of ethyl acetate. The organic phases were combined, washed with saturated NaCl solution, dried over anhydrous Na2SO4 and concentrated again using a rotary evaporator. After drying under high vacuum, 1.07 g of white solid product was obtained in 80% yield (based on 2-chloropyrimidine-4-carbonyl chloride). The melting point of the product ranged from 147.2 °C to 151.4 °C. The product was characterized by the following data: 1H-NMR (CDCl3, 300 MHz) δ (ppm): 6.2 (br.s), 7.25 (s), 7.7 (br.s), 8.1 (d), 8.9 (d).
References
[1] Patent: US5591853, 1997, A
2-Chloropyrimidine-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloropyrimidine-4-carboxylic acid Suppliers
- Tel
- +86-0531-88801869 15090917080
- Fax
- 0531-88801867
- sciencechem@163.com
- Country
- China
- ProdList
- 283
- Advantage
- 55
- Tel
- 512-62706911 13401923197
- Fax
- 0512-62706910
- sales@chemwe.com
- Country
- China
- ProdList
- 94
- Advantage
- 56
- Tel
- 0531-88801869 15090917080
- 2955128025@qq.com
- Country
- China
- ProdList
- 124
- Advantage
- 58
- Tel
- 13376082704 13376084917;
- 3930959291@qq.com
- Country
- China
- ProdList
- 2080
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
View Lastest Price from 2-Chloropyrimidine-4-carboxylic acid manufacturers
- Product
- 2-Chloropyrimidine-4-carboxylic acid 149849-92-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29
- Product
- 2-Chloropyrimidine-4-carboxylic acid 149849-92-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.0%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08
- Product
- 2-Chloropyrimidine-4-carboxylic acid 149849-92-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10