ChemicalBook > CAS DataBase List > 2-Chloropyrimidine-4-carboxylic acid

2-Chloropyrimidine-4-carboxylic acid

Product Name: 2-Chloropyrimidine-4-carboxylic acid
CAS No.: 149849-92-3
Chemical Name: 2-Chloropyrimidine-4-carboxylic acid
Synonyms: AKOS BBS-00002507;CHEMBRDG-BB 4010944;4-Carboxy-2-chloropyrimidine;2-Chloropyrimidine-4-CarboxylicAci;2-Chloro-pyrimidin-4-carboxylic acid;2-Chloropyrimidine-4-carboxylic acid;4-Pyrimidinecarboxylic acid, 2-chloro-;4-Carboxy-2-chloropyrimidine, 4-Carboxy-2-chloro-1,3-diazine
CBNumber: CB6216292
Molecular Formula: C5H3ClN2O2
Formula Weight: 158.54
MOL File: 149849-92-3.mol

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2-Chloropyrimidine-4-carboxylic acid Property

Boiling point:: 411.4±18.0 °C(Predicted)
Density: 1.579
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 2.44±0.10(Predicted)
color: Yellow
InChI: InChI=1S/C5H3ClN2O2/c6-5-7-2-1-3(8-5)4(9)10/h1-2H,(H,9,10)
InChIKey: YMDSUQSBJRDYLI-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(C(O)=O)=N1
CAS DataBase Reference: 149849-92-3(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 22-26-36/37/39
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: C428485
Product name: 2-Chloropyrimidine-4-carboxylicacid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC32666
Product name: 2-Chloropyrimidine-4-carboxylic acid
Packaging: 2g
Price: $70
Updated: 2021/12/16

Matrix Scientific

Product number: 070507
Product name: 2-Chloropyrimidine-4-carboxylic acid
Purity: 95%
Packaging: 5g
Price: $119
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC32666
Product name: 2-Chloropyrimidine-4-carboxylic acid
Packaging: 5G
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC32666
Product name: 2-Chloropyrimidine-4-carboxylic acid
Packaging: 1g
Price: $40
Updated: 2021/12/16

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2-Chloropyrimidine-4-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

Yellow to light brown or brown solid

Uses

2-Chloropyrimidine-4-carboxylic acid is a pharmaceutical intermediate compound used in the preparation of oxazolopyrimidine ketoamides with high active antagonism against TRPA1. This class of drugs can be used in the treatment of pain, itching, inflammation, asthma, cough and other related conditions.

Synthesis

149849-93-4

149849-92-3

Example 5 Preparation of 2-chloropyrimidine-4-carboxamide: Ammonia was passed into 20 mL of tetrahydrofuran for 35 minutes at -6 °C. The reaction system was then warmed to 10 °C and 1.5 g (8.47 mmol) of 2-chloropyrimidine-4-carbonyl chloride was added. The reaction solution was stirred at room temperature for 45 min. Upon completion of the reaction, the reaction solution was concentrated using a rotary evaporator and the residue was poured into 90 mL of saturated NaHCO3 solution. The aqueous phase was extracted three times with 50 mL of ethyl acetate. The organic phases were combined, washed with saturated NaCl solution, dried over anhydrous Na2SO4 and concentrated again using a rotary evaporator. After drying under high vacuum, 1.07 g of white solid product was obtained in 80% yield (based on 2-chloropyrimidine-4-carbonyl chloride). The melting point of the product ranged from 147.2 °C to 151.4 °C. The product was characterized by the following data: 1H-NMR (CDCl3, 300 MHz) δ (ppm): 6.2 (br.s), 7.25 (s), 7.7 (br.s), 8.1 (d), 8.9 (d).

References

[1] Patent: US5591853, 1997, A

2-Chloropyrimidine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

thiosemicarbazide Acetonitrile Potassium carbonate Trifluoroacetic acid Phosphorus oxitrichloride Piperazine 1,4-Dioxane Sodium nitrite Hydrogen bromide Ethyl acetate

Preparation Products

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View Lastest Price from 2-Chloropyrimidine-4-carboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Chloropyrimidine-4-carboxylic acid 149849-92-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Honest Joy Holdings Limited

Product: 2-Chloropyrimidine-4-carboxylic acid 149849-92-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.0%
Supply Ability: 100 tons
Release date: 2022-02-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Chloropyrimidine-4-carboxylic acid 149849-92-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

149849-92-3, 2-Chloropyrimidine-4-carboxylic acidRelated Search:

2-Chloropyrimidine-4-carboxylic acid METHYL 2,4-DICHLOROPYRIMIDINE-6-CARBOXYLATE METHYL 2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOXYLATE 2-(3-CHLOROPHENYL)MALONDIALDEHYDE 2-Chloropyrimidine 4-Pyrimidinecarboxylic acid Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate ethyl 2,4-dichloropyrimidine-5-carboxylate Methyl2,4-Dichloropyrimidine-5-carboxylate Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate 2-CHLORO-6-METHOXY-4-PYRIMIDINECARBOXYLIC ACID ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE ETHYL 2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOXYLATE METHYL 2-CHLORO-6-METHOXYPYRIMIDINE-4-CARBOXYLATE BUTTPARK 153\57-36 2-Chloro-6-pentafluoroethyl-pyrimidine-4-carboxylic acid ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE ETHYL 2-CHLORO-5-METHYL-6-PHENYLPYRIMIDINE-4-CARBOXYLATE

CHEMBRDG-BB 4010944

AKOS BBS-00002507

2-Chloropyrimidine-4-carboxylic acid

4-Pyrimidinecarboxylic acid, 2-chloro-

4-Carboxy-2-chloropyrimidine

2-Chloro-pyrimidin-4-carboxylic acid

4-Carboxy-2-chloropyrimidine, 4-Carboxy-2-chloro-1,3-diazine

2-Chloropyrimidine-4-CarboxylicAci

149849-92-3

C7H9F3N4S

Building Blocks

Heterocycle-Pyrimidine series

pyrimidine

pharmacetical