ChemicalBook > CAS DataBase List > 2,4-Dichloro-6-methylpyrimidine

2,4-Dichloro-6-methylpyrimidine

Product Name
2,4-Dichloro-6-methylpyrimidine
CAS No.
5424-21-5
Chemical Name
2,4-Dichloro-6-methylpyrimidine
Synonyms
6-Methyl-2,4-dichloropyriMidine;2,6-DICHLORO-4-METHYLPYRIMIDINE;NSC 13199;AKOS BBS-00005839;4-Dichloro-6-MethylpyriMidine;2,4-DICHLORO-6-METHYLPYRIMIDE;2,4-dichloro-6-methyl-pyrimidin;2,4-DICHLORO-6-METHYLPYRIMIDINE;2,4-Dichloro-6-methyl-1,3-diazine;2,4-Dichloro-6-methylpyrimidine>
CBNumber
CB8443434
Molecular Formula
C5H4Cl2N2
Formula Weight
163
MOL File
5424-21-5.mol
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2,4-Dichloro-6-methylpyrimidine Property

Melting point:
44-47 °C (lit.)
Boiling point:
219 °C (lit.)
Density 
1.5462 (rough estimate)
refractive index 
1.6300 (estimate)
Flash point:
>230 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Very Slightly, Heated, Sonicated), DMSO (Sparingly, Heated)
form 
powder to crystal
pka
-2.12±0.30(Predicted)
color 
White to Orange to Green
Water Solubility 
Soluble in Chloroform, Ether, Ethyl Acetate and Toluene. Insoluble in water.
BRN 
114295
InChI
InChI=1S/C5H4Cl2N2/c1-3-2-4(6)9-5(7)8-3/h2H,1H3
InChIKey
BTLKROSJMNFSQZ-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(C)=CC(Cl)=N1
CAS DataBase Reference
5424-21-5(CAS DataBase Reference)
EPA Substance Registry System
Pyrimidine, 2,4-dichloro-6-methyl- (5424-21-5)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-27-36/37/39-45
RIDADR 
UN 3263 8/PG 2
WGK Germany 
3
Hazard Note 
Corrosive
TSCA 
T
HazardClass 
8
PackingGroup 
III
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
144185
Product name
2,4-Dichloro-6-methylpyrimidine
Purity
98%
Packaging
25g
Price
$52.5
Updated
2025/07/31
Sigma-Aldrich
Product number
144185
Product name
2,4-Dichloro-6-methylpyrimidine
Purity
98%
Packaging
100g
Price
$165
Updated
2025/07/31
TCI Chemical
Product number
D2958
Product name
2,4-Dichloro-6-methylpyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
D2958
Product name
2,4-Dichloro-6-methylpyrimidine
Purity
>98.0%(GC)
Packaging
25g
Price
$176
Updated
2025/07/31
Usbiological
Product number
D3531-31
Product name
2,4-Dichloro-6-methylpyrimidine|
Packaging
20g
Price
$418
Updated
2021/12/16
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2,4-Dichloro-6-methylpyrimidine Chemical Properties,Usage,Production

Chemical Properties

White to Light Yellow Powder

Uses

2,4-Dichloro-6-methylpyrimidine is used in the synthesis of (2-chloro-6-methyl-pyrimidin-4-yl)-(2,3-dihydro-benzothiazol-6-yl)-amine.

General Description

2,4-Dichloro-6-methylpyrimidine undergoes double cross-coupling reaction with 2-(tributylstannyl)pyridine, followed by aldol condensation to yield 4-arylvinyl-2,6-di(pyridin-2-yl)pyrimidines. It reacts with 1H,1H,2H,2H-perfluorodecanethiol during fluorous synthesis of disubstituted pyrimidines.

Synthesis

626-48-2

5424-21-5

Step 1. 2,4-Dichloro-6-methylpyrimidine (166-01) was prepared from 6-methylpyrimidine-2,4-diol (500 mg, 3.97 mmol) by reacting with phosphoryl chloride (4 mL) according to the literature procedure 49-01 to afford 540 mg of white solid product in 84% yield. Mass spectral analysis showed m/z: 164.7 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 10, p. 1755 - 1757
[2] Molecules, 2012, vol. 17, # 4, p. 4533 - 4544
[3] Patent: WO2018/14802, 2018, A1. Location in patent: Paragraph 0472; 0473
[4] Organic and Biomolecular Chemistry, 2003, vol. 1, # 19, p. 3353 - 3361
[5] Journal of Heterocyclic Chemistry, 1987, vol. 24, # 1, p. 205 - 209

2,4-Dichloro-6-methylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

2-AMINO-6-METHYL-PYRIMIDINE-4-THIOL 6-METHYL-2-(METHYLSULFANYL)PYRIMIDIN-4-YLAMINE 2-CHLORO-6-METHYLPYRIMIDIN-4-AMINE CRIMIDINE 4-AMINO-6-METHYLPYRIMIDINE-2-THIOL 2-Chloro-6-methylpyrimidin-4-ylamine
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View Lastest Price from 2,4-Dichloro-6-methylpyrimidine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
2,4-Dichloro-6-methylpyrimidine 5424-21-5
Price
US $100.00-50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-12
Career Henan Chemical Co
Product
2,4-Dichloro-6-methylpyrimidine 5424-21-5
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-07

5424-21-5, 2,4-Dichloro-6-methylpyrimidine Related Search:

2',4'-Dichloroacetophenone 1,2-Dichloro-4-(chloromethyl)benzene 2-Chloro-5-chloromethylpyridine Dichloromethylsilane 2,4-Dichloropyrimidine Pirimiphos-methyl Dichlorodimethylsilane Sulfamerazine 2,4-DICHLORO-5-NITROPYRIDINE 2,4-Dichloro-6-picoline 2,4-Dichloro-6-methyl-5-nitropyrimidine TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE (9H-FLUOREN-9-YL)METHYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE METHYL 2,4-DICHLOROPYRIMIDINE-6-CARBOXYLATE 2-(3-CHLOROPHENYL)MALONDIALDEHYDE (9H-FLUOREN-9-YL)METHYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE 5-Bromo-2,4-dichloro-6-methylpyrimidine 2,4-Dichloro-5-methylpyrimidine ,98%,2,4-Dichloro-5-methylpyrimidine **Toxic, Stench**,2,4-DICHLORO-5-METHYLPYRIMIDINE

  • AKOS BBS-00005839
  • 2,6-DICHLORO-4-METHYLPYRIMIDINE
  • 2,4-DICHLORO-6-METHYLPYRIMIDINE
  • 2,4-dichloro-6-methyl-pyrimidin
  • 2,4-DICHLORO-6-METHYLPYRIMIDE
  • 2,4-Dichloro-6-methylpyrimidine ,99%
  • 2,4-Dichloro-6-methylpyrimidine,98%
  • 4-Dichloro-6-MethylpyriMidine
  • 6-Methyl-2,4-dichloropyriMidine
  • NSC 13199
  • 2,4-Dichloro-6-methyl-1,3-diazine
  • 2,4-Dichloro-6-methylpyrimidine&gt
  • Pyrimidine, 2,4-dichloro-6-methyl-
  • 2,4-Dichloro-6-methylpyrimidine ISO 9001：2015 REACH
  • 2,4-Dichloro-6-methylpyrimidine, 95%
  • 5424-21-5
  • CH32CHCOCHCH32
  • HETERO CHLORIDE
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  • Nucleotides and Nucleosides
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  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Pyridines, Pyrimidines, Purines and Pteredines