5-(TETRADECYLOXY)-2-FUROIC ACID
- Product Name
- 5-(TETRADECYLOXY)-2-FUROIC ACID
- CAS No.
- 54857-86-2
- Chemical Name
- 5-(TETRADECYLOXY)-2-FUROIC ACID
- Synonyms
- TOFA;mdl14514;RMI-14514;TOFA (RMI14514;RMI14514; MDL14514;TOFA, 10 mM in DMSO;TOFA (RMI14514:MDL14514);5-tetradecyloxy-2-furonicacid;5-(TETRADECYLOXY)-2-FUROIC ACID;5-(TETRADECYLOXY)-2-FUROIC TOFA
- CBNumber
- CB4759746
- Molecular Formula
- C19H32O4
- Formula Weight
- 324.45
- MOL File
- 54857-86-2.mol
5-(TETRADECYLOXY)-2-FUROIC ACID Property
- Melting point:
- 112-115 °C
- Boiling point:
- 441.7±25.0 °C(Predicted)
- Density
- 1.003±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: 2.5 mg/mL
- form
- solid
- pka
- 3.55±0.10(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety
- WGK Germany
- 2
- RTECS
- LU0288000
- HS Code
- 29321900
N-Bromosuccinimide Price
- Product number
- T6575
- Product name
- TOFA
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $240
- Updated
- 2025/07/31
- Product number
- 613450
- Product name
- TOFA
- Packaging
- 5mg
- Price
- $401
- Updated
- 2025/07/31
- Product number
- 10005263
- Product name
- TOFA
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 10005263
- Product name
- TOFA
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- T6575
- Product name
- TOFA
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $949
- Updated
- 2025/07/31
5-(TETRADECYLOXY)-2-FUROIC ACID Chemical Properties,Usage,Production
Description
TOFA (54857-86-2) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1).1 Induces apoptosis in a variety of tumor cell lines.2,3 Stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells.4 TOFA impairs glucose-stimulated insulin secretion after chronic treatment.5
Uses
TOFA has been used as a lipid biosynthesis inhibitor in mesenchymal stromal cells (MSCs), human pluripotent stem cells., an acetyl-CoA carboxylase 1 inhibitor in murine adipocyte cell lines., a lipolysis inhibitor in cancer stem cells (CSCs).
Definition
ChEBI: A member of the class of furans that is 2-furoic acid in which the hydrogen at position 5 is replaced by a tetradecyloxy group.
Biochem/physiol Actions
5-(Tetradecyloxy)-2-furoic acid (TOFA) elicits hypolipidemic?functionality by favoring fatty acid breakdown and at the same time preventing biosynthesis. It induces apoptosis in pancreatic cancer cells and favors tumor suppression.
in vivo
TOFA inhibits COC1/DDP cell growth in ovarian tumor mouse xenografts. The tumor growth rate is signifi cantly inhibited by TOFA compared with the DMSO treated control mice (1649±356.3 vs. 5128±390.4 mm3. No toxicity is observed in the heart, liver, spleen, lung, kidney and intestinal tissues. By inhibiting ACC, TOFA may be a promising small molecule agent for ovarian cancer therapy[2].
References
References/Citations:
(1)Halvorson et al. (1984), Inhibition of fatty acid synthesis in isolated adipocytes by 5-tetradecyloxy)-2-furoic acid; Lipids, 19 851
(2) Guseva et al. (2011), TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status; Cancer Biol. Ther., 12 80
(3) Zhou et al. (2003), Fatty acid synthesis inhibition triggers apoptosis during S phase in human cancer cells; Cancer Res., 63 7330
(4) Schmidt et al. (1999), Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family; Mol. Cell. Endocrinol., 155 51
(5) Ronnebaum et al. (2008), Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism; J. Biol. Chem., 283 14248
5-(TETRADECYLOXY)-2-FUROIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-(TETRADECYLOXY)-2-FUROIC ACID manufacturers
- Product
- 5-(TETRADECYLOXY)-2-FUROIC ACID 54857-86-2
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02