ChemicalBook > CAS DataBase List > Flumethasone 21-pivalate

Flumethasone 21-pivalate

Product Name
Flumethasone 21-pivalate
CAS No.
2002-29-1
Chemical Name
Flumethasone 21-pivalate
Synonyms
Losalen;Lorinden;locorten;locacorten;NSC 107680;21-pivalate;FLUMETHSONEPIVALATE;FLUMETHASONE PIVALATE;Flumethasome pivalate;flumetasone 21-pivalate
CBNumber
CB4762018
Molecular Formula
C27H36F2O6
Formula Weight
494.57
MOL File
2002-29-1.mol
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Flumethasone 21-pivalate Property

Melting point:
>263°C (dec.)
Boiling point:
600.3±55.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
dioxane: soluble4.0ML, clear, colorless to very faintly yellow (50 mg + 4.0 mL dioxane)
form 
solid
pka
11.86±0.70(Predicted)
color 
White to Off-White
optical activity
[α]25/D 71.0 to 82.0°, c = 1 in dioxane
CAS DataBase Reference
2002-29-1(CAS DataBase Reference)
EPA Substance Registry System
Flumethasone-21-pivalate (2002-29-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
40
Safety Statements 
22-36
WGK Germany 
3
RTECS 
TU3832010
HS Code 
2937220000
Toxicity
mouse,LD50,oral,> 5gm/kg (5000mg/kg),Drugs in Japan Vol. 6, Pg. 705, 1982.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F0891
Product name
Flumethasone pivalate
Packaging
100mg
Price
$177
Updated
2023/06/20
Sigma-Aldrich
Product number
F0188500
Product name
Flumethasone pivalate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
f0188500
Price
$153
Updated
2024/03/01
TRC
Product number
F455015
Product name
Flumethasone21-Pivalate
Packaging
10mg
Price
$65
Updated
2021/12/16
TRC
Product number
F455015
Product name
Flumethasone21-Pivalate
Packaging
50mg
Price
$110
Updated
2021/12/16
AK Scientific
Product number
Q560
Product name
Flumethasone pivalate
Packaging
100mg
Price
$238
Updated
2021/12/16
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Flumethasone 21-pivalate Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder.

Uses

An anti-inflammatory anti-itching corticosteroid found in topical creams.

Uses

flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a pivalate, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.

Definition

ChEBI: Flumethasone pivalate is a pivalate ester, a glucocorticoid, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug and an antipruritic drug. It is functionally related to a flumethasone.

brand name

Locorten (Novartis).

Flumethasone 21-pivalate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Flumethasone 21-pivalate manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Flumethasone Pivalate 2002-29-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-25

2002-29-1, Flumethasone 21-pivalateRelated Search:

MAGNESIUM DIPROPYLACETATE HYDRATE Methyl acrylate Estradiol valerate Methyl trimethylacetate Methylparaben Bensulfuron methyl 2-Methylbutyl acetate Dexamethasone Glycidyl tertcarbonate Thiophanate-methyl Pivalic acid Flumethasone 4-tert-Butylcyclohexyl acetate Prednisolone Kresoxim-methyl Methyl Parathion-methyl Isoflupredone

  • 21-pivalate
  • locacorten
  • flumethasone 21-pivalate
  • FLUMETHASONE PIVALATE
  • 6a,9a-difluoro-16a-methyl-prednisolone-21-pivalate
  • 6ALPHA,9-DIFLUORO-11BETA,17,21-TRIHYDROXY-16ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-[2,2-DIMETHYLPROPIONATE]
  • Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-, (6.alpha.,11.beta.,16.alpha.)-
  • 6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate)
  • 6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-pivalate
  • 6α,9α-Difluoro-16α-methylprednisolone 21-pivalate
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  • Pivalic acid, 21-ester with 6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione (8CI)
  • Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-, (6α,11β,16α)-
  • Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl-, 21-pivalate (7CI, 8CI)
  • locorten
  • pregna-1,4-diene-3,20-dione,6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alp
  • flumetasone 21-pivalate
  • Flumethasome pivalate
  • Flumethasone Pivalate (200 mg)
  • FLUMETHSONEPIVALATE
  • (6α,11β,16α)-21-(2,2-DiMethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-Methyl-pregna-1,4-diene-3,20-dione
  • FluMethasone pivalate USP
  • Flumetasone pivalate CRS
  • Flumethasone Pivalate (1274006)
  • Flumethasone Impurity 13(Flumethasone 21-Pivalate)
  • 2002-29-1
  • C27H36F2O6
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