Flumethasone 21-pivalate Property

Melting point:

>263°C (dec.)

Boiling point:

600.3±55.0 °C(Predicted)

Density 

1.27±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

dioxane: soluble4.0ML, clear, colorless to very faintly yellow (50 mg + 4.0 mL dioxane)

form 

solid

pka

11.86±0.70(Predicted)

color 

White to Off-White

optical activity

[α]25/D 71.0 to 82.0°, c = 1 in dioxane

CAS DataBase Reference

2002-29-1(CAS DataBase Reference)

EPA Substance Registry System

Flumethasone-21-pivalate (2002-29-1)

Safety

Hazard Codes 

Xn

Risk Statements 

40

Safety Statements 

22-36

WGK Germany 

3

RTECS 

TU3832010

HS Code 

2937220000

Toxicity

mouse,LD50,oral,> 5gm/kg (5000mg/kg),Drugs in Japan Vol. 6, Pg. 705, 1982.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

Flumethasone 21-pivalate Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder.

Uses

An anti-inflammatory anti-itching corticosteroid found in topical creams.

Uses

flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a pivalate, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.

Definition

ChEBI: Flumethasone pivalate is a pivalate ester, a glucocorticoid, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug and an antipruritic drug. It is functionally related to a flumethasone.

brand name

Locorten (Novartis).