2-Chloro-4,6-dimethoxy-1,3,5-triazine

Product Name: 2-Chloro-4,6-dimethoxy-1,3,5-triazine
CAS No.: 3140-73-6
Chemical Name: 2-Chloro-4,6-dimethoxy-1,3,5-triazine
Synonyms: CDMT;AKOS 89995;CDMT 2-Chloro-4,6-diMethoxy-1,3,5-triazine;Chlorodimethoxytriazine;NSC 46520;6-diMethoxy-1;5-triazine (CDMT);2-Chloro-4,6-dimetho;2-Chloro-4,6-dimethoxy-1;2-CHLORO-4,6-DIMETHOXY-TRIAZINE
CBNumber: CB4775597
Molecular Formula: C5H6ClN3O2
Formula Weight: 175.57
MOL File: 3140-73-6.mol

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2-Chloro-4,6-dimethoxy-1,3,5-triazine Property

Melting point:: 71-74 °C (lit.)
Boiling point:: 99-100 °C (1 mmHg)
Density: 1.7917 (rough estimate)
vapor pressure: 5.8Pa at 25℃
refractive index: 1.5870 (estimate)
Flash point:: 99-100°C/1mm
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform, Methanol
form: Crystalline Powder
pka: 0.33±0.10(Predicted)
color: White to almost white
Water Solubility: insoluble
BRN: 148988
InChI: 1S/C5H6ClN3O2/c1-10-4-7-3(6)8-5(9-4)11-2/h1-2H3
InChIKey: GPIQOFWTZXXOOV-UHFFFAOYSA-N
SMILES: COc1nc(Cl)nc(OC)n1
LogP: 2.105 at 25℃
CAS DataBase Reference: 3140-73-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37-36
RIDADR: UN3077
WGK Germany: 3
HS Code: 29339900
Storage Class: 8A - Combustible corrosive hazardous materials
Hazard Classifications: Aquatic Chronic 2
Eye Dam. 1
Skin Corr. 1B
Skin Sens. 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 375217
Product name: 2-Chloro-4,6-dimethoxy-1,3,5-triazine
Purity: 97%
Packaging: 5g
Price: $65.7
Updated: 2025/07/31

TCI Chemical

Product number: C1676
Product name: 2-Chloro-4,6-dimethoxy-1,3,5-triazine
Purity: >97.0%(HPLC)(T)
Packaging: 5g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: C1676
Product name: 2-Chloro-4,6-dimethoxy-1,3,5-triazine
Purity: >97.0%(HPLC)(T)
Packaging: 25g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: C1676
Product name: 2-Chloro-4,6-dimethoxy-1,3,5-triazine
Purity: >97.0%(HPLC)(T)
Packaging: 250g
Price: $198
Updated: 2025/07/31

TRC

Product number: C365360
Product name: 2-Chloro-4,6-dimethoxy-1,3,5-triazine
Packaging: 100g
Price: $140
Updated: 2021/12/16

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2-Chloro-4,6-dimethoxy-1,3,5-triazine Chemical Properties,Usage,Production

Chemical Properties

white to almost white crystalline powder

Uses

2-Chloro-4,6-dimethoxy-1,3,5-triazine is used as a peptide coupling agent for the purification of peptides. It is used in the synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride through coupling with N-methylmorpholine in tetrahydrofuran. Further, it plays an important role in the production of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, through reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine. In addition to this, it is involved in the preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts through reaction with various tertiary amines.

Uses

2-Chloro-4,6-dimethoxy-1,3,5-triazine may be used in the following studies:

The specific labeling of streptavidin by the modular method for affinity labeling (MoAL).
The preparation of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, via reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine.
The preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts, via reaction with various tertiary amines.
The synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, via coupling with N-methylmorpholine in THF.

General Description

2-Chloro-4,6-dimethoxy-1,3,5-triazine is a stable, yet highly reactive, peptide coupling agent. It is reported as useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported.

Synthesis

A preparation method of 2-chloro-4,6-dimethoxy-1,3,5-triazine comprises the following steps: using cyanuric chloride and sodium methoxide solid as reaction raw materials and N, N-dimethylformamide as a reaction solvent, gradually heating to obtain a 2-chloro-4,6-dimethoxy-1,3,5-triazine crude product, and finally, recrystallizing with heptane for purification. The reaction temperature is controlled to prepare the product, and the yield is up to 91%.

References

[1] Molecules, 2016, vol. 21, # 6,
[2] Patent: WO2016/103185, 2016, A2. Location in patent: Page/Page column 34
[3] Journal of Materials Chemistry C, 2018, vol. 6, # 13, p. 3288 - 3297
[4] Patent: CN103497211, 2016, B. Location in patent: Paragraph 0113
[5] Synthetic Communications, 1996, vol. 26, # 18, p. 3491 - 3494

2-Chloro-4,6-dimethoxy-1,3,5-triazine Preparation Products And Raw materials

Raw materials

Sodium bicarbonate Methanol PETROLEUM ETHER Cyanuric chloride

Preparation Products

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2-Chloro-4,6-dimethoxy-1,3,5-triazine Suppliers

Americas 1 Belgium 2 Canada 3 China 446 Europe 5 France 1 Germany 11 India 50 Ireland 1 Israel 1 Italy 2 Japan 3 Poland 1 Slovakia 1 South Korea 1 Switzerland 5 Ukraine 1 United Kingdom 24 United States 48 Global 607

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View Lastest Price from 2-Chloro-4,6-dimethoxy-1,3,5-triazine manufacturers

.GZ HONESTCHEM CO.,LTD

Product: chlorodimethoxytriazine 3140-73-6
Price: US $1.00/g
Min. Order: 300g
Purity: 99.8%
Supply Ability: 20 TONS
Release date: 2025-12-15

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Chloro-4,6-dimethoxy-1,3,5-triazine/CDMT 3140-73-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%min
Supply Ability: 1000 KG
Release date: 2025-07-09

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Chloro-4,6-dimethoxy-1,3,5-triazine 3140-73-6
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-12-03

3140-73-6, 2-Chloro-4,6-dimethoxy-1,3,5-triazineRelated Search:

1,3,5-Triazine Epichlorohydrin Dimethyldimethoxysilane 4-Methoxybenzylchloride 3-Chloropropyltrimethoxysilane Acetoxyacetyl chloride Difluorochloromethane Chloroacetic acid F26 CDMT, 2-Chloro-4,6-bis(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)-1,3,5-triazine 2-Chloro-4,6-dimethoxy-1,3,5-triazine 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE (3140-73-6) 2-CHLORO-4-(2,4-DIFLUOROPHENOXY)-6-METHOXY-1,3,5-TRIAZINE BIS-RF8 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE 2-CHLORO-4-(2,4-DIMETHYLPHENOXY)-6-METHOXY-1,3,5-TRIAZINE BIS-RF6 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE 2-CHLORO-4-(4-CHLORO-3-METHYLPHENOXY)-6-METHOXY-1,3,5-TRIAZINE 2-CHLORO-4,6-DI(4-FLUOROPHENOXY)-1,3,5-TRIAZINE Dimethoxy

CDMT

AKOS 89995

2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE

2-CHLORO-4,6-DIMETHOXY-TRIAZINE

Chlorodimethoxytriazine

2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE, 9 7%

2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE (CDMT)

2-Chloro-4,6-dimethoxy-1

oro-4,6-dimethoxy-1,3,5-triazine

1,3,5-Triazine, 2-chloro-4,6-dimethoxy-

2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE 98%

2,4-Dimethoxy-6-chloro-1,3,5-triazine

2,4-Dimethoxy-6-chloro-s-triazine

4,6-Dimethoxy-2-chloro-1,3,5-triazine

2-Chloro-4,6-dimetho

5-triazine (CDMT)

6-diMethoxy-1

2-CHLORO 4,6-DIMETHOX 1,3,5-TRIAZINE

4-CHLORO-2,6-DIMETHOXY-1,3.5-TRIAZINE

CDMT 2-Chloro-4,6-diMethoxy-1,3,5-triazine

4,6-DiMethoxy-2-chloro-s-triazine

NSC 46520

2-Chloro-4,6-diMethoxy-1,3,5-triazine, 98% 25GR

2-Chloro-4,6-diMethoxy-1,3,5-triazine, 98% 5GR

2-Chloro-4,6-dimethoxy-s-triazine

2-chloro -4,6-twoMethoxy -1,3,5-three work

2-Chlor-4,6-dimethoxy-1,3,5-triazin

2-Chloro-4,6-dimethoxy-1,3,5-triazine&gt

2-Chloro-4,6-dimethoxy-1,3,5-triazine, 97%, for synthesis

2-Chloro-4,6 Dimethoxy-1,3,5 Triazine extrapure, 99%

3140-73-6

C5H6C1N3O2

C5H6ClN3O2

HETERO CHLORIDE

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Triazines

Miscellaneous

Aromatics

Heterocycles

Miscellaneous Reagents

Biochemistry

Coupling Reactions (Peptide Synthesis)

Peptide Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Triazines

TriazinesBuilding Blocks

Starting Raw Materials & Intermediates

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