ChemicalBook > CAS DataBase List > 2-Chloro-4,6-dimethoxy-1,3,5-triazine

2-Chloro-4,6-dimethoxy-1,3,5-triazine

Product Name
2-Chloro-4,6-dimethoxy-1,3,5-triazine
CAS No.
3140-73-6
Chemical Name
2-Chloro-4,6-dimethoxy-1,3,5-triazine
Synonyms
CDMT;AKOS 89995;CDMT 2-Chloro-4,6-diMethoxy-1,3,5-triazine;Chlorodimethoxytriazine;NSC 46520;6-diMethoxy-1;5-triazine (CDMT);2-Chloro-4,6-dimetho;2-Chloro-4,6-dimethoxy-1;2-CHLORO-4,6-DIMETHOXY-TRIAZINE
CBNumber
CB4775597
Molecular Formula
C5H6ClN3O2
Formula Weight
175.57
MOL File
3140-73-6.mol
More
Less

2-Chloro-4,6-dimethoxy-1,3,5-triazine Property

Melting point:
71-74 °C (lit.)
Boiling point:
99-100 °C (1 mmHg)
Density 
1.7917 (rough estimate)
vapor pressure 
5.8Pa at 25℃
refractive index 
1.5870 (estimate)
Flash point:
99-100°C/1mm
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform, Methanol
form 
Crystalline Powder
pka
0.33±0.10(Predicted)
color 
White to almost white
Water Solubility 
insoluble
BRN 
148988
InChIKey
GPIQOFWTZXXOOV-UHFFFAOYSA-N
LogP
2.105 at 25℃
CAS DataBase Reference
3140-73-6(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37-36
RIDADR 
UN3077
WGK Germany 
3
HS Code 
29339900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
375217
Product name
2-Chloro-4,6-dimethoxy-1,3,5-triazine
Purity
97%
Packaging
5g
Price
$65.7
Updated
2025/07/31
TCI Chemical
Product number
C1676
Product name
2-Chloro-4,6-dimethoxy-1,3,5-triazine
Purity
>97.0%(HPLC)(T)
Packaging
5g
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
C1676
Product name
2-Chloro-4,6-dimethoxy-1,3,5-triazine
Purity
>97.0%(HPLC)(T)
Packaging
25g
Price
$39
Updated
2025/07/31
TCI Chemical
Product number
C1676
Product name
2-Chloro-4,6-dimethoxy-1,3,5-triazine
Purity
>97.0%(HPLC)(T)
Packaging
250g
Price
$198
Updated
2025/07/31
TRC
Product number
C365360
Product name
2-Chloro-4,6-dimethoxy-1,3,5-triazine
Packaging
100g
Price
$140
Updated
2021/12/16
More
Less

2-Chloro-4,6-dimethoxy-1,3,5-triazine Chemical Properties,Usage,Production

Chemical Properties

white to almost white crystalline powder

Uses

2-Chloro-4,6-dimethoxy-1,3,5-triazine is used as a peptide coupling agent for the purification of peptides. It is used in the synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride through coupling with N-methylmorpholine in tetrahydrofuran. Further, it plays an important role in the production of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, through reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine. In addition to this, it is involved in the preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts through reaction with various tertiary amines.

Uses

2-Chloro-4,6-dimethoxy-1,3,5-triazine may be used in the following studies:

  • The specific labeling of streptavidin by the modular method for affinity labeling (MoAL).
  • The preparation of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, via reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine.
  • The preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts, via reaction with various tertiary amines.
  • The synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, via coupling with N-methylmorpholine in THF.

General Description

2-Chloro-4,6-dimethoxy-1,3,5-triazine is a stable, yet highly reactive, peptide coupling agent. It is reported as useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported.

Synthesis

A preparation method of 2-chloro-4,6-dimethoxy-1,3,5-triazine comprises the following steps: using cyanuric chloride and sodium methoxide solid as reaction raw materials and N, N-dimethylformamide as a reaction solvent, gradually heating to obtain a 2-chloro-4,6-dimethoxy-1,3,5-triazine crude product, and finally, recrystallizing with heptane for purification. The reaction temperature is controlled to prepare the product, and the yield is up to 91%.

References

[1] Molecules, 2016, vol. 21, # 6,
[2] Patent: WO2016/103185, 2016, A2. Location in patent: Page/Page column 34
[3] Journal of Materials Chemistry C, 2018, vol. 6, # 13, p. 3288 - 3297
[4] Patent: CN103497211, 2016, B. Location in patent: Paragraph 0113
[5] Synthetic Communications, 1996, vol. 26, # 18, p. 3491 - 3494

2-Chloro-4,6-dimethoxy-1,3,5-triazine Preparation Products And Raw materials

Raw materials

Sodium bicarbonate Methanol PETROLEUM ETHER Cyanuric chloride

Preparation Products

More
Less

2-Chloro-4,6-dimethoxy-1,3,5-triazine Suppliers

Americas 1 Belgium 2 Canada 3 China 446 Europe 5 France 1 Germany 11 India 50 Ireland 1 Israel 1 Italy 2 Japan 3 Poland 1 Slovakia 1 South Korea 1 Switzerland 5 Ukraine 1 United Kingdom 24 United States 48 Global 607
Suzhou Highfine Biotech Co., Ltd
Tel
0512-69209928 18796809688
Fax
0512-68417696
Email
zhouyingxiang@highfine.com
Country
China
ProdList
475
Advantage
75
Z IntellecChem& Tech. Co., Ltd
Tel
0511-15050866711; 15050866711
Fax
QQ:2677337387
Email
contact@zintellec.com
Country
China
ProdList
99
Advantage
62
Jinan Daen Pharmaceutical Technology Co., Ltd
Tel
0531-68657833 15553112864
Fax
-
Email
2098511187@qq.com
Country
China
ProdList
295
Advantage
58
Wisdom Drugs Co., Ltd.
Tel
18261161868
Email
527536256@qq.com
Country
China
ProdList
297
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-029-81024372 17792795018
Fax
029-88380327
Email
1027@dideu.com
Country
China
ProdList
9997
Advantage
58
Chengdu Kelai Hyde Pharmaceutical Technology Co., Ltd
Tel
18482172240
Email
609320203@qq.com
Country
China
ProdList
110
Advantage
58
Qingdao Gelisi Pharmaceutical Co. , Ltd
Tel
189-4623-7973 13375559818
Email
cfy69@163.com
Country
China
ProdList
128
Advantage
58
Qingdao Rongrong Chemical Technology Co., Ltd
Tel
15224422002
Email
2467602940@qq.com
Country
China
ProdList
31
Advantage
58
Shan Dong FengJin Pharmaceutical Co.,Ltd.
Tel
15898960031
Email
linyong@fengjin-pharma.com
Country
China
ProdList
36
Advantage
58
Beijing Leaderherb Bio-Tech. Co., LTD.
Tel
010-51288246 13366708252
Email
300abc@sina.com
Country
China
ProdList
79
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9309
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527621225
Email
1791901229@qq.com
Country
China
ProdList
6945
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Tangshan Moneide Trading Co., Ltd.
Tel
0315-8309571 15633399667
Fax
+86-315-7726572
Email
sales@moneidechem.com
Country
China
ProdList
704
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Aemon Chemical
Tel
0086-755-86198205
Email
acinfo@aemonchem.com
Country
China
ProdList
1931
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 17550508557
Fax
QQ：3470079902
Email
675141927@qq.com
Country
China
ProdList
3199
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Changzhou Chemscaler Pharmtech Co., Ltd.
Tel
0519-81096292 15312577869
Email
chemscaler@yahoo.com.cn
Country
China
ProdList
311
Advantage
60
Shanghai Medpep Co., Ltd
Tel
021-65566949 13901795941
Fax
86-21-51861665
Email
market@medpep.com
Country
China
ProdList
156
Advantage
66
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
More
Less

View Lastest Price from 2-Chloro-4,6-dimethoxy-1,3,5-triazine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Chloro-4,6-dimethoxy-1,3,5-triazine/CDMT 3140-73-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%min
Supply Ability
1000 KG
Release date
2025-07-09
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Chloro-4,6-dimethoxy-1,3,5-triazine 3140-73-6
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-12-03
Watson Biotechnology Co.,Ltd
Product
CDMT 2-Chloro-4,6-dimethoxy-1,3,5-triazine 3140-73-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-09-26

3140-73-6, 2-Chloro-4,6-dimethoxy-1,3,5-triazineRelated Search:

Epichlorohydrin Dimethyldimethoxysilane 4-Methoxybenzylchloride 3-Chloropropyltrimethoxysilane Acetoxyacetyl chloride 1,3,5-Triazine Difluorochloromethane Chloroacetic acid F26 CDMT, 2-Chloro-4,6-bis(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)-1,3,5-triazine 2-Chloro-4,6-dimethoxy-1,3,5-triazine 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE (3140-73-6) 2-CHLORO-4-(2,4-DIFLUOROPHENOXY)-6-METHOXY-1,3,5-TRIAZINE BIS-RF8 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE 2-CHLORO-4-(2,4-DIMETHYLPHENOXY)-6-METHOXY-1,3,5-TRIAZINE BIS-RF6 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE 2-CHLORO-4-(4-CHLORO-3-METHYLPHENOXY)-6-METHOXY-1,3,5-TRIAZINE 2-CHLORO-4,6-DI(4-FLUOROPHENOXY)-1,3,5-TRIAZINE Dimethoxy

  • CDMT
  • AKOS 89995
  • 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE
  • 2-CHLORO-4,6-DIMETHOXY-TRIAZINE
  • Chlorodimethoxytriazine
  • 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE, 9 7%
  • 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE (CDMT)
  • 2-Chloro-4,6-dimethoxy-1
  • oro-4,6-dimethoxy-1,3,5-triazine
  • 1,3,5-Triazine, 2-chloro-4,6-dimethoxy-
  • 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE 98%
  • 2,4-Dimethoxy-6-chloro-1,3,5-triazine
  • 2,4-Dimethoxy-6-chloro-s-triazine
  • 4,6-Dimethoxy-2-chloro-1,3,5-triazine
  • 2-Chloro-4,6-dimetho
  • 5-triazine (CDMT)
  • 6-diMethoxy-1
  • 2-CHLORO 4,6-DIMETHOX 1,3,5-TRIAZINE
  • 4-CHLORO-2,6-DIMETHOXY-1,3.5-TRIAZINE
  • CDMT 2-Chloro-4,6-diMethoxy-1,3,5-triazine
  • 4,6-DiMethoxy-2-chloro-s-triazine
  • NSC 46520
  • 2-Chloro-4,6-diMethoxy-1,3,5-triazine, 98% 25GR
  • 2-Chloro-4,6-diMethoxy-1,3,5-triazine, 98% 5GR
  • 2-Chloro-4,6-dimethoxy-s-triazine
  • 2-chloro -4,6-twoMethoxy -1,3,5-three work
  • 2-Chlor-4,6-dimethoxy-1,3,5-triazin
  • 2-Chloro-4,6-dimethoxy-1,3,5-triazine&gt
  • 2-Chloro-4,6-dimethoxy-1,3,5-triazine, 97%, for synthesis
  • 2-Chloro-4,6 Dimethoxy-1,3,5 Triazine extrapure, 99%
  • 3140-73-6
  • C5H6C1N3O2
  • C5H6ClN3O2
  • HETERO CHLORIDE
  • Building Blocks
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Triazines
  • Miscellaneous
  • Aromatics
  • Heterocycles
  • Miscellaneous Reagents
  • Biochemistry
  • Coupling Reactions (Peptide Synthesis)
  • Peptide Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Triazines
  • TriazinesBuilding Blocks
  • Starting Raw Materials & Intermediates
  • bc0001