4-Nitrophenethylamine hydrochloride

Product Name: 4-Nitrophenethylamine hydrochloride
CAS No.: 29968-78-3
Chemical Name: 4-Nitrophenethylamine hydrochloride
Synonyms: 4-NITROPHENYLETHYLAMINE HYDROCHLORIDE;4-NITROPHENYLETHYLAMINE HCL;P-nitrophenyl riMantadine hydrochloride;4-Nitrophcnethylamine;4-NITROPHENYLAMINEHCL;4-NITROPHENETHYLAMINE HCL;Mirabegron Impurity 6 HCl;P-NITROPHENYLETHYLAMINE HCL;Mirabegron EP Impurity E HCl;4-Nitro Phenyl-(ethy-2-amine)
CBNumber: CB4775890
Molecular Formula: C8H11ClN2O2
Formula Weight: 202.64
MOL File: 29968-78-3.mol

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4-Nitrophenethylamine hydrochloride Property

Melting point:: 200 °C (dec.)(lit.)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in methanol almost transparency.
form: Crystalline Powder
color: Yellow to yellow-green
BRN: 3568915
Stability:: Hygroscopic
InChI: InChI=1S/C8H10N2O2.ClH/c9-6-5-7-1-3-8(4-2-7)10(11)12;/h1-4H,5-6,9H2;1H
InChIKey: JVMHULJEYUQYSH-UHFFFAOYSA-N
SMILES: C1([N+]([O-])=O)C=CC(CCN)=CC=1.Cl
CAS DataBase Reference: 29968-78-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-40
Safety Statements: 22-24/25-36-26
WGK Germany: 3
HS Code: 29214990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: OTV000173
Product name: 4-Nitrophenethylamine hydrochloride
Purity: AldrichCPR
Packaging: 1g
Price: $179
Updated: 2025/07/31

Sigma-Aldrich

Product number: 184802
Product name: 4-Nitrophenethylamine hydrochloride
Purity: 95%
Packaging: 5g
Price: $194
Updated: 2025/07/31

TCI Chemical

Product number: N0648
Product name: 2-(4-Nitrophenyl)ethylamine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: N0648
Product name: 2-(4-Nitrophenyl)ethylamine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $61
Updated: 2025/07/31

TRC

Product number: N496995
Product name: 4-Nitrophenethylamine hydrochloride
Packaging: 10g
Price: $130
Updated: 2021/12/16

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4-Nitrophenethylamine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

yellow to brown crystalline powder and chunks

Uses

4-Nitrophenethylamine hydrochloride was used in the synthesis of ortho-metalated primary phenethylamines complexes containing six-membered palladacycles and N-(4-nitrophenethyl)formamide.

Preparation

The preparation of 4-Nitrophenethylamine hydrochloride is as follows:Ten mL of 2M HCl was then added in a one-pot fashion, and, in all cases but threonine, the reaction vessel was heated to 190°Cover 5 min with stirring and then allowed to cool. In the case of the temperature-sensitive threonine, soxhlet extraction with toluene was performed at 80°C to remove R-carvone from the reaction mixture. The aqueous reaction mixture was washed three times with 25 mL of ether, and then water solvent was distilled off from the hydrochloride salt. The hydrochloride salt was transferred to a vacuum oven and dried overnight at 150 °C and 10 Torr.

Synthesis

6270-07-1

29968-78-3

In a reactor, 140 kg of N-(4-nitrophenylethyl)acetamide was dissolved in 190 kg of ethanol with constant stirring until complete dissolution. The pH of the reaction mixture was adjusted to 1 using 2 mol/L hydrochloric acid solution.Subsequently, the reaction mixture was heated to 80°C and maintained at this temperature for 20 hrs. Upon completion of the reaction, the reaction solution was cooled to room temperature to induce precipitation of the solid product. The crude product was purified by recrystallization through methanol, and after filtration and centrifugation, 116 kg of 4-nitrophenylethylamine hydrochloride was obtained, and the purity of the final product was 99.6%. The yield of this synthesis step was 84.7%.

References

[1] Patent: CN107759477, 2018, A. Location in patent: Paragraph 0063

4-Nitrophenethylamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Nitrophenethylamine hydrochloride Suppliers

Americas 1 Belgium 1 Canada 1 China 375 Europe 1 France 2 Germany 8 India 62 Japan 4 Switzerland 3 The Netherlands 1 Ukraine 1 United Kingdom 14 United States 42 Global 516

Henan Dongyao Pharmaceutical Technology Co., Ltd

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Hubei Tuobang Chemical Co., Ltd.

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Anhui Dexinjia Biopharm Co., Ltd

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Hangzhou Lenny Technology Co. , Ltd.

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Liaoning Haowei Technology Co., LTD

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Zhangjiagang Xikai Chemical Co.,Ltd

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Aikon International Limited

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Shanghai Witofly Chemical Co. ,Ltd.

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Cangzhou Enke Pharma Tech Co.,ltd.

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Ereal Chemical Co., Ltd.

Tel: 0831-6888461 15181138905
Fax: QQ：97273224
Email: sales@erealchem.com
Country: China
ProdList: 84
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View Lastest Price from 4-Nitrophenethylamine hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Nitrophenethylamine hydrochloride 29968-78-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-02

R&D Scientific Inc.

Product: 4-Nitrophenylethylamine hydrochloride 29968-78-3
Price: US $790.00/Kg
Min. Order: 0.100Kg
Purity: 98
Supply Ability: 5000 Kg
Release date: 2025-03-28

Hebei Yanxi Chemical Co., Ltd.

Product: 4-Nitrophenethylamine hydrochloride 29968-78-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100tons
Release date: 2023-09-14

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29968-78-3

C8H10O2N2xHCL

O2NC6H4CH2CH2NH2HCl

C8H10N2O2CIH

C8H10N10O2HCl

C8H11ClN2O8

AMINE

Amine Salts

Building Blocks

Nitrogen Compounds

Organic Building Blocks

Nitro / Nitriles

Anilines, Aromatic Amines and Nitro Compounds

API intermediates