L-4-Nitrophenylalanine methyl ester hydrochloride

Product Name: L-4-Nitrophenylalanine methyl ester hydrochloride
CAS No.: 17193-40-7
Chemical Name: L-4-Nitrophenylalanine methyl ester hydrochloride
Synonyms: 4-NO2-Phe-oMe.HCL;4-NO2-L-Phe-Ome.HCl;L-Phe(4-NO2)-OMe·HCl;H-PHE(4-NO2)-OME HCL;H-PHE(P-NO2)-OME HCL;π-Nitro-L-Phe-OMe·HCl;H-P-NITRO-PHE-OME HCL;Zomitriptan Impurity 01;Melphalan Impurity 21 HCl;P-NITRO-PHENYLALANINE-OME HCL
CBNumber: CB8126427
Molecular Formula: C10H13ClN2O4
Formula Weight: 260.67
MOL File: 17193-40-7.mol

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L-4-Nitrophenylalanine methyl ester hydrochloride Property

Melting point:: 210-214 °C
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder to crystal
color: White to Light yellow
optical activity: 20.9° (c=1.0 g/100ml, ETOH)
BRN: 5176380
CAS DataBase Reference: 17193-40-7(CAS DataBase Reference)

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Safety

Risk Statements: 22-43-36
Safety Statements: 22-36/37-24/25
RIDADR: 2811
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III
HS Code: 29225090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 658421
Product name: (S)-(+)-4-Nitrophenylalanine methyl ester hydrochloride
Purity: 97%
Packaging: 10g
Price: $781
Updated: 2025/07/31

TCI Chemical

Product number: N0878
Product name: 4-Nitro-L-phenylalanine Methyl Ester Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: N0878
Product name: 4-Nitro-L-phenylalanine Methyl Ester Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $91
Updated: 2025/07/31

TRC

Product number: N497015
Product name: 4-Nitro-L-phenylalanine Methyl Ester Hydrochloride
Packaging: 1g
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 285554
Product name: 4-Nitro-L-phenylalanine methyl ester hydrochloride
Packaging: 10g
Price: $347
Updated: 2021/12/16

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L-4-Nitrophenylalanine methyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

4-Nitro-L-Phenylalanine Methyl Ester Hydrochloride, is an intermediate in the synthesis of various pharmaceutical compounds. It can be used for the preparation of Matijing-Su derivatives as potent anti-HBV agents.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

949-99-5

17193-40-7

Thionyl chloride (1.03 mL, 14.2 mmol) was slowly added dropwise to a suspension of (S)-2-amino-3-(4-nitrophenyl)propionic acid (0.995 g, 4.73 mmol) dissolved in 10 mL of methanol at 0 °C. After the dropwise addition, the reaction system was gradually warmed up to room temperature. Subsequently, the reaction mixture was heated to reflux the reaction overnight. Upon completion of the reaction, the reaction solution was concentrated by distillation under reduced pressure. The crude product was purified by recrystallization using a mixed solvent of methanol/ethyl acetate, and finally 1.012 g of (S)-4-nitrophenylalanine methyl ester hydrochloride was obtained in 95% yield.

References

[1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 22, p. 3686 - 3700
[2] Journal of Medicinal Chemistry, 1995, vol. 38, # 18, p. 3566 - 3580
[3] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5407 - 5413
[4] Chemistry - A European Journal, 2017, vol. 23, # 24, p. 5824 - 5829
[5] New Journal of Chemistry, 2017, vol. 41, # 23, p. 14723 - 14729

L-4-Nitrophenylalanine methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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L-4-Nitrophenylalanine methyl ester hydrochloride Suppliers

Americas 1 China 157 Europe 1 Germany 4 India 17 Japan 3 Switzerland 3 The Netherlands 1 United Kingdom 4 United States 27 Global 218

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View Lastest Price from L-4-Nitrophenylalanine methyl ester hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: L-4-Nitrophenylalanine Methyl Ester Hydrochloride 17193-40-7
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-22

Hebei Zhuanglai Chemical Trading Co Ltd

Product: L-4-Nitrophenylalanine Methyl Ester Hydrochloride 17193-40-7
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-19

Hebei Zhuanglai Chemical Trading Co Ltd

Product: L-4-Nitrophenylalanine Methyl Ester Hydrochloride 17193-40-7
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-26

17193-40-7, L-4-Nitrophenylalanine methyl ester hydrochlorideRelated Search:

D-Alanine Bensulfuron methyl Methyl acrylate EC 2.6.1.2 METSULFURON METHYL Phenprobamate Glycine methyl ester hydrochloride Kresoxim-methyl L-Alanine methyl ester hydrochloride Topotecan hydrochloride TRIS(4-NITROPHENYL) PHOSPHATE Methyl salicylate Thiophanate-methyl H-4-NITRO-PHE-OET HCL Methyl H-PHE-ALA-OH PHE-GLY-GLY 4-Methylphenyl-L-alanine

P-NITRO-PHENYLALANINE-OME HCL

3-(4-Nitrophenyl)-L-alanine methylester hydrochloride

4-Nitro-L-Phenylalanine Methyl Ester HCl

(S)-Methyl-4-Nitro Phenyl Alaninate hydrochloride

4-Nitro-L-Phenylalanine methyl ester monohydrochloride

4-NO2-Phe-oMe.HCL

L-4-Nitrophenylalanine methyl ester hydrochloride

(S)-Methyl 2-aMino-3-(4-nitrophenyl)propanoate hydrochloride

4-Nitro-<sMall>L</sMall>-phenylalanine Methyl Ester Hydrochloride

p-Nitrophenylalanine methyl ester hydrochloride, Methyl 4-nitro-L-phenylalaninate hydrochloride

L-4-Nitrophenylalanine methyl ester hydrochloride (S)-4-Nitrophenylalanine methyl ester hydrochloride

L-Phe(4-NO2)-OMe·HCl

methyl (2S)-2-amino-3-(4-nitrophenyl)propanoate hydrochloride

(S)-(+)-4-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE

(S)-4-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE

(S)-ALFA-AMINO-4-NITRO BENZENEPROPANOIC ACID METHYL ESTER HYDROCHLORIDE

P-NITRO-L-PHENYLALANINE METHYL ESTER HCL

P-NITRO-L-PHENYLALANINE METHYL ESTER HYDROCHLORIDE

P-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE

4-NO2-L-Phe-Ome.HCl

4-Nitro-L-phenylalanine methyl ester hydrochloride≥ 99% (HPLC)

π-Nitro-L-Phe-OMe·HCl

4-NITRO-L-PHENYLALANINE METHYL ESTER HYDROCHLORIDE

H-P-NITRO-PHE-OME HCL

H-PHE(4-NO2)-OME HCL

H-PHE(P-NO2)-OME HCL

L-4-NITROPHENYLALANINE METHYL ESTER HCL

METHYL 4-NITRO-L-PHENYLALANINATE HYDROCHLORIDE

METHYL (S)-2-AMINO-3-(4-NITROPHENYL)PROPANOIATE HYDROCHLORIDE

4-Nitro-L-phenylalanineMethylEsterHydrochloride&gt

L-Phenylalanine, 4-nitro-, methyl ester, monohydrochloride

L-4-Nitrophenylalanine methyl ester hydrochloride USP/EP/BP

(S)-Methyl-4-nitrophenylalanate hydrochloride

Melphalan Impurity 21 HCl

(<i>S</i>)-(+)-4-Nitrophenylalanine methyl ester hydrochloride

Zomitriptan Impurity 01

17193-40-7

C10H13ClN2O4

C10H12ClN2O4

C10H12N2O4ClH

O2NC6H4CH2CHNH2CO2CH3HCl

Peptide Synthesis

Phenylalanine Derivatives

Specialty Synthesis

Unnatural Amino Acid Derivatives

Phenylalanine [Phe, F]