ChemicalBook > CAS DataBase List > L-4-Nitrophenylalanine methyl ester hydrochloride

L-4-Nitrophenylalanine methyl ester hydrochloride

Product Name
L-4-Nitrophenylalanine methyl ester hydrochloride
CAS No.
17193-40-7
Chemical Name
L-4-Nitrophenylalanine methyl ester hydrochloride
Synonyms
4-NO2-Phe-oMe.HCL;4-NO2-L-Phe-Ome.HCl;L-Phe(4-NO2)-OMe·HCl;H-PHE(4-NO2)-OME HCL;H-PHE(P-NO2)-OME HCL;π-Nitro-L-Phe-OMe·HCl;H-P-NITRO-PHE-OME HCL;Zomitriptan Impurity 01;Melphalan Impurity 21 HCl;P-NITRO-PHENYLALANINE-OME HCL
CBNumber
CB8126427
Molecular Formula
C10H13ClN2O4
Formula Weight
260.67
MOL File
17193-40-7.mol
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L-4-Nitrophenylalanine methyl ester hydrochloride Property

Melting point:
210-214 °C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder to crystal
color 
White to Light yellow
optical activity
20.9° (c=1.0 g/100ml, ETOH)
BRN 
5176380
CAS DataBase Reference
17193-40-7(CAS DataBase Reference)
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Safety

Risk Statements 
22-43-36
Safety Statements 
22-36/37-24/25
RIDADR 
2811
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
658421
Product name
(S)-(+)-4-Nitrophenylalanine methyl ester hydrochloride
Purity
97%
Packaging
10g
Price
$781
Updated
2025/07/31
TCI Chemical
Product number
N0878
Product name
4-Nitro-L-phenylalanine Methyl Ester Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$23
Updated
2025/07/31
TCI Chemical
Product number
N0878
Product name
4-Nitro-L-phenylalanine Methyl Ester Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$91
Updated
2025/07/31
Usbiological
Product number
285554
Product name
4-Nitro-L-phenylalanine methyl ester hydrochloride
Packaging
10g
Price
$347
Updated
2021/12/16
TRC
Product number
N497015
Product name
4-Nitro-L-phenylalanine Methyl Ester Hydrochloride
Packaging
1g
Price
$45
Updated
2021/12/16
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L-4-Nitrophenylalanine methyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

4-Nitro-L-Phenylalanine Methyl Ester Hydrochloride, is an intermediate in the synthesis of various pharmaceutical compounds. It can be used for the preparation of Matijing-Su derivatives as potent anti-HBV agents.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

949-99-5

17193-40-7

Thionyl chloride (1.03 mL, 14.2 mmol) was slowly added dropwise to a suspension of (S)-2-amino-3-(4-nitrophenyl)propionic acid (0.995 g, 4.73 mmol) dissolved in 10 mL of methanol at 0 °C. After the dropwise addition, the reaction system was gradually warmed up to room temperature. Subsequently, the reaction mixture was heated to reflux the reaction overnight. Upon completion of the reaction, the reaction solution was concentrated by distillation under reduced pressure. The crude product was purified by recrystallization using a mixed solvent of methanol/ethyl acetate, and finally 1.012 g of (S)-4-nitrophenylalanine methyl ester hydrochloride was obtained in 95% yield.

References

[1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 22, p. 3686 - 3700
[2] Journal of Medicinal Chemistry, 1995, vol. 38, # 18, p. 3566 - 3580
[3] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5407 - 5413
[4] Chemistry - A European Journal, 2017, vol. 23, # 24, p. 5824 - 5829
[5] New Journal of Chemistry, 2017, vol. 41, # 23, p. 14723 - 14729

L-4-Nitrophenylalanine methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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L-4-Nitrophenylalanine methyl ester hydrochloride Suppliers

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View Lastest Price from L-4-Nitrophenylalanine methyl ester hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
L-4-Nitrophenylalanine Methyl Ester Hydrochloride 17193-40-7
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-22
Hebei Zhuanglai Chemical Trading Co Ltd
Product
L-4-Nitrophenylalanine Methyl Ester Hydrochloride 17193-40-7
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-19
Hebei Zhuanglai Chemical Trading Co Ltd
Product
L-4-Nitrophenylalanine Methyl Ester Hydrochloride 17193-40-7
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-26

17193-40-7, L-4-Nitrophenylalanine methyl ester hydrochlorideRelated Search:

D-Alanine Bensulfuron methyl Methyl acrylate EC 2.6.1.2 METSULFURON METHYL Phenprobamate Glycine methyl ester hydrochloride Kresoxim-methyl L-Alanine methyl ester hydrochloride Topotecan hydrochloride TRIS(4-NITROPHENYL) PHOSPHATE Methyl salicylate Thiophanate-methyl H-4-NITRO-PHE-OET HCL Methyl H-PHE-ALA-OH PHE-GLY-GLY 4-Methylphenyl-L-alanine

  • P-NITRO-PHENYLALANINE-OME HCL
  • 3-(4-Nitrophenyl)-L-alanine methylester hydrochloride
  • 4-Nitro-L-Phenylalanine Methyl Ester HCl
  • (S)-Methyl-4-Nitro Phenyl Alaninate hydrochloride
  • 4-Nitro-L-Phenylalanine methyl ester monohydrochloride
  • 4-NO2-Phe-oMe.HCL
  • L-4-Nitrophenylalanine methyl ester hydrochloride
  • (S)-Methyl 2-aMino-3-(4-nitrophenyl)propanoate hydrochloride
  • 4-Nitro-<sMall>L</sMall>-phenylalanine Methyl Ester Hydrochloride
  • p-Nitrophenylalanine methyl ester hydrochloride, Methyl 4-nitro-L-phenylalaninate hydrochloride
  • L-4-Nitrophenylalanine methyl ester hydrochloride (S)-4-Nitrophenylalanine methyl ester hydrochloride
  • L-Phe(4-NO2)-OMe·HCl
  • methyl (2S)-2-amino-3-(4-nitrophenyl)propanoate hydrochloride
  • (S)-(+)-4-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE
  • (S)-4-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE
  • (S)-ALFA-AMINO-4-NITRO BENZENEPROPANOIC ACID METHYL ESTER HYDROCHLORIDE
  • P-NITRO-L-PHENYLALANINE METHYL ESTER HCL
  • P-NITRO-L-PHENYLALANINE METHYL ESTER HYDROCHLORIDE
  • P-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE
  • 4-NO2-L-Phe-Ome.HCl
  • 4-Nitro-L-phenylalanine methyl ester hydrochloride≥ 99% (HPLC)
  • π-Nitro-L-Phe-OMe·HCl
  • 4-NITRO-L-PHENYLALANINE METHYL ESTER HYDROCHLORIDE
  • H-P-NITRO-PHE-OME HCL
  • H-PHE(4-NO2)-OME HCL
  • H-PHE(P-NO2)-OME HCL
  • L-4-NITROPHENYLALANINE METHYL ESTER HCL
  • METHYL 4-NITRO-L-PHENYLALANINATE HYDROCHLORIDE
  • METHYL (S)-2-AMINO-3-(4-NITROPHENYL)PROPANOIATE HYDROCHLORIDE
  • 4-Nitro-L-phenylalanineMethylEsterHydrochloride&gt
  • L-Phenylalanine, 4-nitro-, methyl ester, monohydrochloride
  • L-4-Nitrophenylalanine methyl ester hydrochloride USP/EP/BP
  • (S)-Methyl-4-nitrophenylalanate hydrochloride
  • Melphalan Impurity 21 HCl
  • (<i>S</i>)-(+)-4-Nitrophenylalanine methyl ester hydrochloride
  • Zomitriptan Impurity 01
  • 17193-40-7
  • C10H13ClN2O4
  • C10H12ClN2O4
  • C10H12N2O4ClH
  • O2NC6H4CH2CHNH2CO2CH3HCl
  • Peptide Synthesis
  • Phenylalanine Derivatives
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • Phenylalanine [Phe, F]