2-AMINO-4-METHOXYBENZYL ALCOHOL
- Product Name
- 2-AMINO-4-METHOXYBENZYL ALCOHOL
- CAS No.
- 187731-65-3
- Chemical Name
- 2-AMINO-4-METHOXYBENZYL ALCOHOL
- Synonyms
- 2-AMINO-4-METHOXYBENZYL ALCOHOL;2-Amino-4-methoxybenzenemethanol;(2-aMino-4-Methoxyphenyl)Methanol;Benzenemethanol, 2-amino-4-methoxy-;Benzenemethanol, 2-amino-4-methoxy- (9CI)
- CBNumber
- CB4777218
- Molecular Formula
- C8H11NO2
- Formula Weight
- 153.18
- MOL File
- 187731-65-3.mol
2-AMINO-4-METHOXYBENZYL ALCOHOL Property
- Boiling point:
- 335.1±27.0 °C(Predicted)
- Density
- 1.182±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 14.28±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A898690
- Product name
- (2-Amino-4-methoxyphenyl)methanol
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- A898690
- Product name
- (2-Amino-4-methoxyphenyl)methanol
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 7466DF
- Product name
- (2-Amino-4-methoxyphenyl)methanol
- Packaging
- 1g
- Price
- $802
- Updated
- 2021/12/16
- Product number
- A157129
- Product name
- (2-Amino-4-methoxyphenyl)methanol
- Purity
- 95%
- Packaging
- 100mg
- Price
- $37
- Updated
- 2021/12/16
- Product number
- A157129
- Product name
- (2-Amino-4-methoxyphenyl)methanol
- Purity
- 95%
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
2-AMINO-4-METHOXYBENZYL ALCOHOL Chemical Properties,Usage,Production
Synthesis
22996-23-2
187731-65-3
General procedure for the synthesis of (2-amino-4-methoxyphenyl)methanol from 3-methoxy-2-nitrobenzyl alcohol: to a solution of commercially available 4-methoxy-2-nitrobenzoic acid (4.0 g, 20.66 mmol) in tetrahydrofuran (20 mL) was added N-methylmorpholine (2.2 mL, 20 mmol) at -15 °C and under nitrogen protection followed by the addition of chloroformic acid in portions of isobutyl chloroformate (2.6 mL, 20 mmol). After 5 min of reaction, the reaction mixture was filtered and the solid was washed with tetrahydrofuran (20 mL). The filtrate was cooled to -15 °C and aqueous sodium borohydride (3M, 10 mL) was added to it. After stirring the reaction for 5 minutes, the reaction mixture was partitioned between water and dichloromethane and the aqueous layer was extracted with dichloromethane (3 x 100 mL). The organic layers were combined, washed with brine, dried over magnesium sulfate and concentrated under reduced pressure. The residue was redissolved in tetrahydrofuran (35 mL), palladium-carbon catalyst (10%, 400 mg) was added, and the reaction was stirred under hydrogen atmosphere for 18 hours. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with hexane/ethyl acetate (3:2) as eluent to give 744 mg (24% yield) of the target product as a yellow solid.1H-NMR (DMSO-d6) δ: 3.63 (s, 3H); 4.30 (s, 2H); 4.84-4.96 (m, 2H); 6.08 (dd, 1H); 6.20 (d 1H); 6.90 (d, 1H).
References
[1] Synlett, 2017, vol. 28, # 14, p. 1724 - 1728
[2] Patent: WO2006/134378, 2006, A1. Location in patent: Page/Page column 110
2-AMINO-4-METHOXYBENZYL ALCOHOL Preparation Products And Raw materials
Raw materials
Preparation Products
2-AMINO-4-METHOXYBENZYL ALCOHOL Suppliers
- Tel
- 0535-6385396
- Fax
- +86 (535) 638-9971
- info@carbottpharm.com
- Country
- China
- ProdList
- 957
- Advantage
- 56
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16075
- Advantage
- 64
- Tel
- 86(512)5235 8471 17715136450
- Fax
- 86(512)5235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 4169
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 17663603912
- Fax
- +86-536- 8637276
- 2710256076@qq.com
- Country
- China
- ProdList
- 196
- Advantage
- 56
- Tel
- 13764913901
- Fax
- -
- info@angtibio.com
- Country
- China
- ProdList
- 4985
- Advantage
- 55
- Tel
- 400-685-9117
- Fax
- 021-51816740
- market@bepharm.com
- Country
- China
- ProdList
- 15081
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 13356901049
- Fax
- QQ：1025383091
- 3119594100@qq.com
- Country
- China
- ProdList
- 7964
- Advantage
- 55
- Tel
- 025-66113011 13155353615
- Fax
- (7)02557626880
- qzhang@aikonchem.com
- Country
- China
- ProdList
- 15394
- Advantage
- 58
- Tel
- 17368696818
- Country
- China
- ProdList
- 1984
- Advantage
- 58
- Tel
- +8615838112936
- alfa10@alfachem.cn
- Country
- China
- ProdList
- 12921
- Advantage
- 58
- Tel
- 0371-63682289 15538176268
- Fax
- QQ：1875164801
- jacschem@163.com
- Country
- China
- ProdList
- 9926
- Advantage
- 58
- Tel
- 0371-0371-53732842 13383863444
- Fax
- QQ：3002612166
- 3002612166@qq.com
- Country
- China
- ProdList
- 9996
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 2383948258 19172820304
- 2383948258@qq.com
- Country
- China
- ProdList
- 12987
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58
- Tel
- 531-87153728 13805401165
- xufeng192@126.com
- Country
- China
- ProdList
- 3964
- Advantage
- 58
- Tel
- 13356901049
- mark@sklnchem.cn
- Country
- China
- ProdList
- 7997
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50751
- Advantage
- 58
- Tel
- 18151111370
- 1046215251@qq.com
- Country
- China
- ProdList
- 8718
- Advantage
- 58
- Tel
- 021-57520305 13795461237
- zhuruyan@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58
- Tel
- 15863541132
- 18366413387@163.com
- Country
- China
- ProdList
- 3898
- Advantage
- 58
- Tel
- 400-6206333 13167063860
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 48457
- Advantage
- 58
- Tel
- 0371-86259281 13223061139
- 893596907@qq.com
- Country
- China
- ProdList
- 7993
- Advantage
- 58
- Tel
- 15683496527 18220923020
- 630940531@qq.com
- Country
- China
- ProdList
- 490
- Advantage
- 58
- Tel
- 15972496547
- 15972496547@163.com
- Country
- China
- ProdList
- 2087
- Advantage
- 58
- Tel
- 17715136450
- 2439673774@qq.com
- Country
- China
- ProdList
- 15647
- Advantage
- 58
- Tel
- 13583079096
- 18366413387@163.com
- Country
- China
- ProdList
- 3881
- Advantage
- 58
- Tel
- 15890142075
- 3555133855@qq.com
- Country
- China
- ProdList
- 9853
- Advantage
- 58
- Tel
- +86-88938639 +86-17705817739
- info@dycnchem.com
- Country
- China
- ProdList
- 53899
- Advantage
- 58
- Tel
- 17301778918
- Country
- CHINA
- ProdList
- 105
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@atomaxchem.com
- Country
- China
- ProdList
- 6489
- Advantage
- 43