ChemicalBook > CAS DataBase List > HARMINE HYDROCHLORIDE

HARMINE HYDROCHLORIDE

Product Name: HARMINE HYDROCHLORIDE
CAS No.: 343-27-1
Chemical Name: HARMINE HYDROCHLORIDE
Synonyms: 5S)-4;4-[[(4R;HarMine.HC;HARMINE HCL;BANISTERIN HCL;HARMINE HYDROCHLORID;harminemonohydrochlo;HARMINE HYDROCHLORIDE;CATHARANTHIN TARTRATE;HarmineHydrochloride>
CBNumber: CB4780696
Molecular Formula: C13H13ClN2O
Formula Weight: 248.71
MOL File: 343-27-1.mol

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HARMINE HYDROCHLORIDE Property

Melting point:: 265-270°C
storage temp.: 2-8°C
solubility: Soluble in Water (up to 25 mg/ml).
form: powder
color: off-white to pale green
Merck: 14,4616
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
LogP: 3.173 (est)
CAS DataBase Reference: 343-27-1(CAS DataBase Reference)
EPA Substance Registry System: Harmine hydrochloride (343-27-1)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-40
Safety Statements: 22-36
RIDADR: 1544
WGK Germany: 3
RTECS: MG9450000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00461
Product name: Harmine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 100mg
Price: $88.1
Updated: 2025/07/31

TCI Chemical

Product number: H0002
Product name: Harmine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 100mg
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: H0002
Product name: Harmine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $118
Updated: 2025/07/31

ApexBio Technology

Product number: N2182
Product name: Harmine hydrochloride
Packaging: 500mg
Price: $50
Updated: 2021/12/16

Chem-Impex

Product number: 21756
Product name: Harminehydrochloride,99%(HPLC)
Purity: 99%(HPLC)
Packaging: 1G
Price: $53.2
Updated: 2021/12/16

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HARMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Harmine (343-27-1) is a selective competitive and reversible inhibitor of MAO-A (IC50?= 8 μM).1?Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC50‘s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 μM; DYRK4 = 80 μM).2,3?Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells (GSLC’s) possibly via inhibition of Akt phosphorylation.4?Harmine has also been shown to possess antimicrobial, antifungal, antiplasmodial, antitumor, antioxidant, antimutagenic and antigenotoxic properties.5?Inhibits osteoclast differentiation and bone resorption via downregulation of c-Fos and NFATc1 induced by RANKL.6

Chemical Properties

yellow to slightly green crystalline powder

Uses

Harmine Monohydrochloride is an anti-viral agents for the treatment of EV71 infection. It inhibits enterovirus 71 replication by targeting NF-κB pathway.

in vivo

It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group^[4].

IC 50

5-HT_2A Receptor: 397 nM (Ki); DYRK1A

Purification Methods

The hydrate crystallises as fluorescent crystals from water. The anhydrous salt has m 319o. [Beilstein 23/12 V 237.]

References

[1] WOUTERS J. Structural aspects of monoamine oxidase and its reversible inhibition.[J]. Current medicinal chemistry, 1998, 5 2: 137-162.
[2] ANNE SEIFERT Paul R C Lindsey A Allan. DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine[J]. The FEBS journal, 2008, 275 24: 6268-6280. DOI:10.1111/j.1742-4658.2008.06751.x
[3] NORA GÖCKLER. Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation[J]. The FEBS journal, 2009, 276 21: 6324-6337. DOI:10.1111/j.1742-4658.2009.07346.x
[4] HUAILEI LIU. Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma.[J]. Journal of Neuro-Oncology, 2013, 112 1: 39-48. DOI:10.1007/s11060-012-1034-x
[5] K PATEL . A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid “Harmine”[J]. Asian Pacific journal of tropical biomedicine, 2012, 2 8: Pages 660-664. DOI:10.1016/s2221-1691(12)60116-6
[6] TAKAYUKI YONEZAWA . Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo[J]. European journal of pharmacology, 2011, 650 2: Pages 511-518. DOI:10.1016/j.ejphar.2010.10.048

HARMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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HARMINE HYDROCHLORIDE Suppliers

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View Lastest Price from HARMINE HYDROCHLORIDE manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: HARMINE HYDROCHLORIDE 343-27-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-28

Changsha Staherb Natural Ingredients Co., Ltd.

Product: HARMINE HYDROCHLORIDE 343-27-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: >99% HPLC
Supply Ability: 1000KG
Release date: 2022-09-22

BINBO BIOLOGICAL CO.,LTD

Product: Harmine Hydrochloride 343-27-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000 kg
Release date: 2024-05-10

343-27-1, HARMINE HYDROCHLORIDERelated Search:

Cevadine veratramine HARMALOL BANISTERINE MONOHYDRATE Xanthiazone L-Hyoscyamine HARMALINE Daurinoline VERATRIDINE Xanthiside HARMALOL HCL menisdaurin 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one daurisoline HARMINE HYDROCHLORIDE Vasicine HARMINE HYDROCHLORIDE HYDRATE HARMINE HYDROCHLORIDE DIHYDRATE

HarMine.HC

7-METHOXY-1-METHYL-9H-PYRIDO[3,4-B]INDOLE HCL

(3,4-b)indole,7-Methoxy-1-Methyl-9h-pyrido(Monohydrochloride

BANISTERINE HYDROCHLORIDE

BANISTERIN HCL

HARMINE HCL

HARMINE HYDROCHLORIDE

4-b)indole,7-methoxy-1-methyl-9h-pyrido(monohydrochloride

harminemonohydrochloride

7-METHOXY-1-METHYL-9H-PYRIDO[3,4-B]INDOLE HYDROCHLORIDE

HARMINE HYDROCHLORIDE HYDRATE 98%

HARMINE HYDROCHLORID

CATHARANTHIN TARTRATE

DL-ANABASINE Hydrochloride

harminemonohydrochlo

Harmine hydrochloride hydrate,98%

7-methoxy-1-methyl-9H-pyrido[3,4-b]indole chloride

HarmineHydrochloride&gt

telepathine hydrochloride

HARMINE HYDROCHLORIDE USP/EP/BP

4-[[(4R

5S)-4

343-27-1

54186-68-1

C13H12N2OHClxH2O

CNS stimulant.

Alkaloids

Indole Alkaloids

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Inhibitors

Alkaloids

Biochemistry

Indole Alkaloids