ChemicalBook > CAS DataBase List > HARMINE HYDROCHLORIDE

HARMINE HYDROCHLORIDE

Product Name
HARMINE HYDROCHLORIDE
CAS No.
343-27-1
Chemical Name
HARMINE HYDROCHLORIDE
Synonyms
5S)-4;4-[[(4R;HarMine.HC;HARMINE HCL;BANISTERIN HCL;HARMINE HYDROCHLORID;harminemonohydrochlo;HARMINE HYDROCHLORIDE;CATHARANTHIN TARTRATE;HarmineHydrochloride>
CBNumber
CB4780696
Molecular Formula
C13H13ClN2O
Formula Weight
248.71
MOL File
343-27-1.mol
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HARMINE HYDROCHLORIDE Property

Melting point:
265-270°C
storage temp. 
2-8°C
solubility 
Soluble in Water (up to 25 mg/ml).
form 
powder
color 
off-white to pale green
Merck 
14,4616
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
LogP
3.173 (est)
CAS DataBase Reference
343-27-1(CAS DataBase Reference)
EPA Substance Registry System
Harmine hydrochloride (343-27-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-40
Safety Statements 
22-36
RIDADR 
1544
WGK Germany 
3
RTECS 
MG9450000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB00461
Product name
Harmine hydrochloride
Purity
≥98% (HPLC)
Packaging
100mg
Price
$85.7
Updated
2024/03/01
TCI Chemical
Product number
H0002
Product name
Harmine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$18
Updated
2024/03/01
TCI Chemical
Product number
H0002
Product name
Harmine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$104
Updated
2024/03/01
Chem-Impex
Product number
21756
Product name
Harmine hydrochloride
Purity
≥ 98% (HPLC)
Packaging
5G
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0009747
Product name
Harmine hydrochloride
Packaging
20mg
Price
$180
Updated
2021/12/16
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HARMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Harmine (343-27-1) is a selective competitive and reversible inhibitor of MAO-A (IC50?= 8 μM).1?Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC50‘s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 μM; DYRK4 = 80 μM).2,3?Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells (GSLC’s) possibly via inhibition of Akt phosphorylation.4?Harmine has also been shown to possess antimicrobial, antifungal, antiplasmodial, antitumor, antioxidant, antimutagenic and antigenotoxic properties.5?Inhibits osteoclast differentiation and bone resorption via downregulation of c-Fos and NFATc1 induced by RANKL.6

Chemical Properties

yellow to slightly green crystalline powder

Uses

Harmine Monohydrochloride is an anti-viral agents for the treatment of EV71 infection. It inhibits enterovirus 71 replication by targeting NF-κB pathway.

Purification Methods

The hydrate crystallises as fluorescent crystals from water. The anhydrous salt has m 319o. [Beilstein 23/12 V 237.]

References

1) Wouters (1998)?Structural Aspects of Monoamine Oxidase and its Reversible Inhibition?Current Medicinal Chemistry,?5?137 2) Seifert?et al. (2008)?DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine; FEBS J.,?275?6268 3) Gockler?et al. (2009)?Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite outgrowth; FEBS J.,?276?6324 4) Liu?et al. (2013)?Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma; J .Neurooncol.,?112?39 5) Patel?et al. (2012)?A review on medical importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid ‘Harmine’; Asian Pac. J. Trop. Biomed.,?2?660 6) Yoneazwa?et al. (2011)?Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo; Eur. J. Pharmacol.,?650?511

HARMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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HARMINE HYDROCHLORIDE Suppliers

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View Lastest Price from HARMINE HYDROCHLORIDE manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.
Product
HARMINE HYDROCHLORIDE 343-27-1
Price
US $0.00/KG
Min. Order
1KG
Purity
>99% HPLC
Supply Ability
1000KG
Release date
2022-09-22
BINBO BIOLOGICAL CO.,LTD
Product
Harmine Hydrochloride 343-27-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000 kg
Release date
2024-05-10
Shanghai Standard Technology Co., Ltd.
Product
Harmine Hydrochloride 343-27-1
Price
US $0.00/ASSAYS
Min. Order
5ASSAYS
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-16

343-27-1, HARMINE HYDROCHLORIDERelated Search:

HARMALOL BANISTERINE MONOHYDRATE Xanthiazone L-Hyoscyamine HARMALINE Daurinoline VERATRIDINE Xanthiside veratramine HARMALOL HCL menisdaurin 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one VERATRINE daurisoline HARMINE HYDROCHLORIDE Vasicine HARMINE HYDROCHLORIDE HYDRATE HARMINE HYDROCHLORIDE DIHYDRATE

  • HarMine.HC
  • 7-METHOXY-1-METHYL-9H-PYRIDO[3,4-B]INDOLE HCL
  • (3,4-b)indole,7-Methoxy-1-Methyl-9h-pyrido(Monohydrochloride
  • BANISTERINE HYDROCHLORIDE
  • BANISTERIN HCL
  • HARMINE HCL
  • HARMINE HYDROCHLORIDE
  • 4-b)indole,7-methoxy-1-methyl-9h-pyrido(monohydrochloride
  • harminemonohydrochloride
  • 7-METHOXY-1-METHYL-9H-PYRIDO[3,4-B]INDOLE HYDROCHLORIDE
  • HARMINE HYDROCHLORIDE HYDRATE 98%
  • HARMINE HYDROCHLORID
  • CATHARANTHIN TARTRATE
  • DL-ANABASINE Hydrochloride
  • harminemonohydrochlo
  • Harmine hydrochloride hydrate,98%
  • 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole chloride
  • HarmineHydrochloride&gt
  • telepathine hydrochloride
  • HARMINE HYDROCHLORIDE USP/EP/BP
  • 4-[[(4R
  • 5S)-4
  • 343-27-1
  • 54186-68-1
  • C13H12N2OHClxH2O
  • CNS stimulant.
  • Alkaloids
  • Indole Alkaloids
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Inhibitors
  • Alkaloids
  • Biochemistry
  • Indole Alkaloids