COLIVELIN

ChemicalBook > CAS DataBase List > COLIVELIN

Product Name: COLIVELIN
CAS No.: 867021-83-8
Chemical Name: COLIVELIN
Synonyms: COLIVELIN;Colivelin (human);SALLRSIPAPAGASRLLLLTGEIDLP;SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO;H-SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-OH;Amyloid-β,β-amyloid peptide,STAT,Colivelin,Inhibitor,inhibit,disease,Neuroprotectant,Abeta,ischemic,brain,neurological,alzheimer,injury;Colivelin trifluoroacetate salt H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH trifluoroacetate salt;L-Proline, L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-
CBNumber: CB4795124
Molecular Formula: C119H206N32O35
Formula Weight: 2645.15
MOL File: 867021-83-8.mol

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COLIVELIN Property

Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in DMSO; insoluble in EtOH; ≥15 mg/mL in H2O
form: solid
color: White
Water Solubility: Soluble to 1 mg/ml in 20% ethanol / water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24239
Product name: Colivelin
Purity: ≥95%
Packaging: 500μg
Price: $242
Updated: 2024/03/01

Cayman Chemical

Product number: 24239
Product name: Colivelin
Purity: ≥95%
Packaging: 1mg
Price: $364
Updated: 2024/03/01

Tocris

Product number: 3945
Product name: Colivelin
Packaging: 500U
Price: $314
Updated: 2021/12/16

TRC

Product number: C641530
Product name: Colivelin
Packaging: 5mg
Price: $2475
Updated: 2021/12/16

Usbiological

Product number: 255021
Product name: Colivelin
Packaging: 500ug
Price: $573
Updated: 2021/12/16

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COLIVELIN Chemical Properties,Usage,Production

Description

Colivelin is a potent synthetic peptide activator of STAT3 that has neuroprotective activity. It protects approximately 50 and 100% of mouse primary cortical neurons from cell death induced by amyloid β (1-43) (Aβ43) when used at concentrations of 10 and 100 fM, respectively. Colivelin protects against cell death induced by V642I-APP in a CaM kinase IV (CaMKIV) and STAT3-dependent manner. It increases STAT3 phosphorylation in vitro and in vivo, an effect that correlates with improvements in working memory. Colivelin (10 pmol every six days) rescues deficits in spatial working memory in a mouse model of Alzheimer’s disease induced by intracerebroventricular injection of Aβ25-35. It also improves motor performance and prolongs survival in a mouse model of amyotrophic lateral sclerosis (ALS).

Uses

Colivelin is a peptide that offers neuroprotective effects against Alzheimer''s Disease (AD). It is also an activator of STAT3, a transcription factor involved with the JAK2/STAT3 pathway. Aberration in this pathway is linked to the pathogenesis of AD. Neuroprotective product.

storage

Store at -20°C

COLIVELIN Preparation Products And Raw materials

Raw materials

Preparation Products

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COLIVELIN Suppliers

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View Lastest Price from COLIVELIN manufacturers

Hebei Kangcang new material Technology Co., LTD

Product: Colivelin trifluoroacetate salt 867021-83-8
Price: US $20.00-10.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20
Release date: 2024-04-17

Career Henan Chemical Co

Product: COLIVELIN 867021-83-8
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2020-03-05

867021-83-8, COLIVELINRelated Search:

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COLIVELIN

H-SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-OH

Colivelin (human)

SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO

Colivelin trifluoroacetate salt H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH trifluoroacetate salt

L-Proline, L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-

Amyloid-β,β-amyloid peptide,STAT,Colivelin,Inhibitor,inhibit,disease,Neuroprotectant,Abeta,ischemic,brain,neurological,alzheimer,injury

SALLRSIPAPAGASRLLLLTGEIDLP

867021-83-8

C119H206N32O35

Amyloid beta-peptide and related