COLIVELIN
- Product Name
- COLIVELIN
- CAS No.
- 867021-83-8
- Chemical Name
- COLIVELIN
- Synonyms
- COLIVELIN;Colivelin (human);SALLRSIPAPAGASRLLLLTGEIDLP;SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO;H-SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-OH;Amyloid-β,β-amyloid peptide,STAT,Colivelin,Inhibitor,inhibit,disease,Neuroprotectant,Abeta,ischemic,brain,neurological,alzheimer,injury;Colivelin trifluoroacetate salt H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH trifluoroacetate salt;L-Proline, L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-
- CBNumber
- CB4795124
- Molecular Formula
- C119H206N32O35
- Formula Weight
- 2645.15
- MOL File
- 867021-83-8.mol
COLIVELIN Property
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in DMSO; insoluble in EtOH; ≥15 mg/mL in H2O
- form
- solid
- color
- White
- Water Solubility
- Soluble to 1 mg/ml in 20% ethanol / water
N-Bromosuccinimide Price
- Product number
- 24239
- Product name
- Colivelin
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $242
- Updated
- 2024/03/01
- Product number
- 24239
- Product name
- Colivelin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $364
- Updated
- 2024/03/01
- Product number
- 3945
- Product name
- Colivelin
- Packaging
- 500U
- Price
- $314
- Updated
- 2021/12/16
- Product number
- C641530
- Product name
- Colivelin
- Packaging
- 5mg
- Price
- $2475
- Updated
- 2021/12/16
- Product number
- 255021
- Product name
- Colivelin
- Packaging
- 500ug
- Price
- $573
- Updated
- 2021/12/16
COLIVELIN Chemical Properties,Usage,Production
Description
Colivelin is a potent synthetic peptide activator of STAT3 that has neuroprotective activity. It protects approximately 50 and 100% of mouse primary cortical neurons from cell death induced by amyloid β (1-43) (Aβ43) when used at concentrations of 10 and 100 fM, respectively. Colivelin protects against cell death induced by V642I-APP in a CaM kinase IV (CaMKIV) and STAT3-dependent manner. It increases STAT3 phosphorylation in vitro and in vivo, an effect that correlates with improvements in working memory. Colivelin (10 pmol every six days) rescues deficits in spatial working memory in a mouse model of Alzheimer’s disease induced by intracerebroventricular injection of Aβ25-35. It also improves motor performance and prolongs survival in a mouse model of amyotrophic lateral sclerosis (ALS).
Uses
Colivelin is a peptide that offers neuroprotective effects against Alzheimer''s Disease (AD). It is also an activator of STAT3, a transcription factor involved with the JAK2/STAT3 pathway. Aberration in this pathway is linked to the pathogenesis of AD. Neuroprotective product.
storage
Store at -20°C
COLIVELIN Preparation Products And Raw materials
Raw materials
Preparation Products
COLIVELIN Suppliers
View Lastest Price from COLIVELIN manufacturers
- Product
- Colivelin trifluoroacetate salt 867021-83-8
- Price
- US $20.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20
- Release date
- 2024-04-17
- Product
- COLIVELIN 867021-83-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2020-03-05