Tandospirone
- Product Name
- Tandospirone
- CAS No.
- 87760-53-0
- Chemical Name
- Tandospirone
- Synonyms
- (3aR,4S,7R,7aS)-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione;Sediel;TANDOSPIRONE;(3aR,4S,7R,7aS)-rel-;Tandospirone (SM3997);Tandospirone [inn:ban];TANDOSPIRONE USP/EP/BP;Tandospirone hydrochloride;3a,4,7,7a-Hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-4,7-methano-1H-isoindole-1,3(2H)-dione;(1R*,2S*,3R*,4S*)-N-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-2,3-norbornanedicarboximide citrate salt
- CBNumber
- CB4796484
- Molecular Formula
- C21H29N5O2
- Formula Weight
- 383.49
- MOL File
- 87760-53-0.mol
Tandospirone Property
- Melting point:
- 112-113.5°
- Boiling point:
- 613.9±65.0 °C(Predicted)
- Density
- 1.239±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMSO: soluble38mg/mL
- pka
- 7.71±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T6704
- Product name
- Tandospirone
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- T6704
- Product name
- Tandospirone
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $537
- Updated
- 2024/03/01
- Product number
- 2854
- Product name
- Tandospironehydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 256809
- Product name
- Tandospirone hydrochloride
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- 290605
- Product name
- Tandospirone hydrochloride
- Packaging
- 5mg
- Price
- $545
- Updated
- 2021/12/16
Tandospirone Chemical Properties,Usage,Production
Description
Tandospirone is another 5-HT1A receptor agonist under development by Sumitomo Pharmaceutical Co., Ltd., in Japan and Pfizer in the United States. Results of phase II and phase III clinical trials show that tandospirone is effective for the treatment of anxiety neurosis. Significant improvement is also observed in patients with psychosomatic disease, phobia, and depersonalization (Murasaki 1995). The results have shown that initial treatment should be started at 30 mg daily, and the dose should be increased up to 60 mg daily according to symptoms (Murasaki 1995). A double-blind comparative study with diazepam revealed that tandospirone tends to be superior to diazepam in patients with depressive neurosis, whereas diazepam may be more effective than tandospirone in severely ill patients (Murasaki et al. 1992).
Originator
Sumitomo (Japan)
Uses
Tandospirone is a 5HT1A receptor partial agonist. Studies indicate that tandospirone significantly reduces haloperidol-induced bradykinesia in a dose dependent manner. The potency of Tandospirone is equal to that of buspirone and approximate one-half that of diazepam. The potency of Tandospirone at dopamine antagonistic action is less than 1/4 that of buspirone.
Definition
ChEBI: Tandospirone is a dicarboximide that is (3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione which is substituted by a 4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl group at position 2. It is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM). It has a role as an antidepressant and an anxiolytic drug. It is a N-alkylpiperazine, a N-arylpiperazine, a member of pyrimidines, a bridged compound and a dicarboximide. It is a conjugate base of a tandospirone(1+).
Preparation
Tandospirone is attained from the exo diels-alder adduct of maleic anhydride and cyclopentadiene in a four step convergent approach.
brand name
Sediel
Biological Activity
5-HT 1A receptor partial agonist (K i = 27 nM) that displays selectivity over 5-HT 2 , 5-HT 1C , α 1 , α 2 , D 1 and D 2 receptors (K i values ranging from 1300-41000 nM). Inactive at 5-HT uptake sites, 5-HT 1B , β -adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.
References
[1] shimizu h1, hirose a, tatsuno t, nakamura m, katsube j. pharmacological properties of sm-3997: a new anxioselective anxiolytic candidate. jpn j pharmacol. 1987 dec; 45(4):493-500.
Tandospirone Preparation Products And Raw materials
Raw materials
Preparation Products
Tandospirone Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from Tandospirone manufacturers
- Product
- Tandospirone 87760-53-0
- Price
- US $55.00-550.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-07
- Product
- Tandospirone 87760-53-0
- Price
- US $0.00/gram
- Min. Order
- 10gram
- Purity
- 99.99
- Supply Ability
- 10Tons
- Release date
- 2024-03-18
- Product
- TANDOSPIRONE 87760-53-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-23