6-(TRIFLUOROMETHYL)-1H-INDAZOLE

Product Name: 6-(TRIFLUOROMETHYL)-1H-INDAZOLE
CAS No.: 954239-22-6
Chemical Name: 6-(TRIFLUOROMETHYL)-1H-INDAZOLE
Synonyms: 6-(TRIFLUOROMETHYL)INDAZOLE;6-(TRIFLUOROMETHYL)-1H-INDAZOLE;1H-Indazole, 6-(trifluoromethyl)-
CBNumber: CB4798211
Molecular Formula: C8H5F3N2
Formula Weight: 186.13
MOL File: 954239-22-6.mol

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6-(TRIFLUOROMETHYL)-1H-INDAZOLE Property

Boiling point:: 268.5±35.0 °C(Predicted)
Density: 1.447±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 12.15±0.40(Predicted)
form: crystalline powder
color: Amber/tan
InChI: InChI=1S/C8H5F3N2/c9-8(10,11)6-2-1-5-4-12-13-7(5)3-6/h1-4H,(H,12,13)
InChIKey: PFAFARJWFBPNIN-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(C(F)(F)F)=C2)C=N1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T899265
Product name: 6-(trifluoromethyl)-1h-indazole
Packaging: 50mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044895
Product name: 6-(TRIFLUOROMETHYL)-1H-INDAZOLE
Purity: 95.00%
Packaging: 50MG
Price: $117.6
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-3-T6
Product name: 6-(Trifluoromethyl)-1H-indazole
Packaging: 100mg
Price: $67
Updated: 2021/12/16

Apolloscientific

Product number: PC51050
Product name: 6-(Trifluoromethyl)-1H-indazole
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-3-T6
Product name: 6-(Trifluoromethyl)-1H-indazole
Packaging: 250mg
Price: $135
Updated: 2021/12/16

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6-(TRIFLUOROMETHYL)-1H-INDAZOLE Chemical Properties,Usage,Production

Synthesis

89763-93-9

954239-22-6

The general procedure for the synthesis of 6-(trifluoromethyl)-1H-indazole using 2-fluoro-4-(trifluoromethyl)benzaldehyde as starting material was as follows: to a stirring solution of 2-fluoro-4-(trifluoromethyl)benzaldehyde (200 mg, 1.04 mmol, 1.0 eq.) in THF (5 mL) at room temperature was added NH2OMe (174 mg, 2.08 mmol 2.0 eq.). The reaction mixture was stirred at room temperature for 3 h. After stirring, (NH2)2-H2O (67 mg, 2.08 mmol, 2.0 eq.) was added, followed by refluxing the mixture for 3 h. The reaction was completed with a solution of saturated NH2OMe (5 mL). Upon completion of the reaction, the reaction was quenched with saturated aqueous Na2S2O3 and extracted with EtOAc. The organic phase was dried over MgSO4 and concentrated under reduced pressure to give the crude product. The crude product was purified by Yamazen automated chromatography using Hex:EtOAc = 9:1 as eluent to yield 6-(trifluoromethyl)-1H-indazole (121 mg, 37% yield) as a colorless solid. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3) and MS (ESI): 1H NMR δ 10.57 (1H, br s), 8.18 (1H, s), 7.89 (1H, dd, J = 9.0,0.5 Hz), 7.42 (1H, dd, J = 9.0,3.0 Hz); MS (ESI) m/z 203 [(M + Na)+], retention time 1.00 min (condition A).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 14, p. 2408 - 2412

6-(TRIFLUOROMETHYL)-1H-INDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(TRIFLUOROMETHYL)-1H-INDAZOLE Suppliers

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View Lastest Price from 6-(TRIFLUOROMETHYL)-1H-INDAZOLE manufacturers

Career Henan Chemical Co

Product: 6-(TRIFLUOROMETHYL)-1H-INDAZOLE 954239-22-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-12-18

954239-22-6, 6-(TRIFLUOROMETHYL)-1H-INDAZOLERelated Search:

5-BROMO-3-HYDROXY (1H)INDAZOLE 5-Chloro-1-methyl-1H-indazole 3,5-DICHLORO (1H)INDAZOLE 4-METHOXY (1H)INDAZOLE ethyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate 3-BROMO-6-(TRIFLUOROMETHYL) (1H)INDAZOLE 3-CHLORO-6-(TRIFLUOROMETHYL) (1H)INDAZOLE 4-BROMO-3-IODO-6-(TRIFLUOROMETHYL) (1H)INDAZOLE 6-(TRIFLUOROMETHYL)-1H-INDAZOLE 3-IODO-6-(TRIFLUOROMETHYL) (1H)INDAZOLE 3-HYDROXY-6-TRIFLUROMETHYL (1H)INDAZOLE 3-AMINO-6-(TRIFLUOROMETHYL)-1H-INDAZOLE 3,4-DIBROMO-6-TRIFLUOROMETHYL (1H)INDAZOLE 6-TRIFLUOROMETHYL-1H-INDAZOLE-3-CARBOXYLIC ACID METHYL ESTER 6-(TRIFLUOROMETHYL)-1H-INDAZOLE-3-CARBOXYLIC ACID 6-(TRIFLUOROMETHYL)-4-BROMO INDAZOLE 6-TRIFLUOROMETHYL-1H-INDAZOLE-3-CARBALDEHYDE 3-CYANO-6-TRIFLUOROMETHYLINDAZOLE

6-(TRIFLUOROMETHYL)INDAZOLE

6-(TRIFLUOROMETHYL)-1H-INDAZOLE

1H-Indazole, 6-(trifluoromethyl)-

954239-22-6