6-(TRIFLUOROMETHYL)-1H-INDAZOLE
- Product Name
- 6-(TRIFLUOROMETHYL)-1H-INDAZOLE
- CAS No.
- 954239-22-6
- Chemical Name
- 6-(TRIFLUOROMETHYL)-1H-INDAZOLE
- Synonyms
- 6-(TRIFLUOROMETHYL)INDAZOLE;6-(TRIFLUOROMETHYL)-1H-INDAZOLE;1H-Indazole, 6-(trifluoromethyl)-
- CBNumber
- CB4798211
- Molecular Formula
- C8H5F3N2
- Formula Weight
- 186.13
- MOL File
- 954239-22-6.mol
6-(TRIFLUOROMETHYL)-1H-INDAZOLE Property
- Boiling point:
- 268.5±35.0 °C(Predicted)
- Density
- 1.447±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 12.15±0.40(Predicted)
- form
- crystalline powder
- color
- Amber/tan
- InChI
- InChI=1S/C8H5F3N2/c9-8(10,11)6-2-1-5-4-12-13-7(5)3-6/h1-4H,(H,12,13)
- InChIKey
- PFAFARJWFBPNIN-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC(C(F)(F)F)=C2)C=N1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T899265
- Product name
- 6-(trifluoromethyl)-1h-indazole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3H32-3-T6
- Product name
- 6-(Trifluoromethyl)-1H-indazole
- Packaging
- 100mg
- Price
- $67
- Updated
- 2021/12/16
- Product number
- PC51050
- Product name
- 6-(Trifluoromethyl)-1H-indazole
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- HCH0044895
- Product name
- 6-(TRIFLUOROMETHYL)-1H-INDAZOLE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $117.6
- Updated
- 2021/12/16
- Product number
- 3H32-3-T6
- Product name
- 6-(Trifluoromethyl)-1H-indazole
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
6-(TRIFLUOROMETHYL)-1H-INDAZOLE Chemical Properties,Usage,Production
Synthesis
89763-93-9
954239-22-6
The general procedure for the synthesis of 6-(trifluoromethyl)-1H-indazole using 2-fluoro-4-(trifluoromethyl)benzaldehyde as starting material was as follows: to a stirring solution of 2-fluoro-4-(trifluoromethyl)benzaldehyde (200 mg, 1.04 mmol, 1.0 eq.) in THF (5 mL) at room temperature was added NH2OMe (174 mg, 2.08 mmol 2.0 eq.). The reaction mixture was stirred at room temperature for 3 h. After stirring, (NH2)2-H2O (67 mg, 2.08 mmol, 2.0 eq.) was added, followed by refluxing the mixture for 3 h. The reaction was completed with a solution of saturated NH2OMe (5 mL). Upon completion of the reaction, the reaction was quenched with saturated aqueous Na2S2O3 and extracted with EtOAc. The organic phase was dried over MgSO4 and concentrated under reduced pressure to give the crude product. The crude product was purified by Yamazen automated chromatography using Hex:EtOAc = 9:1 as eluent to yield 6-(trifluoromethyl)-1H-indazole (121 mg, 37% yield) as a colorless solid. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3) and MS (ESI): 1H NMR δ 10.57 (1H, br s), 8.18 (1H, s), 7.89 (1H, dd, J = 9.0,0.5 Hz), 7.42 (1H, dd, J = 9.0,3.0 Hz); MS (ESI) m/z 203 [(M + Na)+], retention time 1.00 min (condition A).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 14, p. 2408 - 2412
6-(TRIFLUOROMETHYL)-1H-INDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
6-(TRIFLUOROMETHYL)-1H-INDAZOLE Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from 6-(TRIFLUOROMETHYL)-1H-INDAZOLE manufacturers
- Product
- 6-(TRIFLUOROMETHYL)-1H-INDAZOLE 954239-22-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-12-18