ChemicalBook > CAS DataBase List > GSK620

GSK620

Product Name
GSK620
CAS No.
2088410-46-0
Chemical Name
GSK620
Synonyms
GSK620;1-benzyl-N5-cyclopropyl-N3-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxamide;3,5-Pyridinedicarboxamide, N5-cyclopropyl-1,2-dihydro-N3-methyl-2-oxo-1-(phenylmethyl)-;Inhibitor,oral,GSK 620,phenotype,selectivity,GSK-620,whole,anti-inflammatory,GSK620,Epigenetic Reader Domain,inhibit,human,blood
CBNumber
CB48067227
Molecular Formula
C18H19N3O3
Formula Weight
325.36
MOL File
2088410-46-0.mol
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GSK620 Property

Boiling point:
618.6±55.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 62.5 mg/mL (192.09 mM; Need ultrasonic)
pka
12.43±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0142650
Product name
GSK620
Purity
99.86%
Packaging
5mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0142650
Product name
GSK620
Purity
99.86%
Packaging
10mg
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-0142650
Product name
GSK620
Purity
99.86%
Packaging
25mg
Price
$950
Updated
2021/12/16
ChemScene
Product number
CS-0142650
Product name
GSK620
Purity
99.86%
Packaging
50mg
Price
$1450
Updated
2021/12/16
ChemScene
Product number
CS-0142650
Product name
GSK620
Purity
99.86%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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GSK620 Chemical Properties,Usage,Production

Biological Activity

GSK620 is a potent and orally active pan-BD2 inhibitor with excellent broad selectivity, developability and in vivo oral pharmacokinetics. GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 shows an anti-inflammatory phenotype in human whole blood[1]. GSK620 shows an anti-inflammatory phenotype in human whole blood. Human blood samples are stimulated with LPS, which produces a strong immune response. The monocyte chemattractant protein 1 (MCP-1/CCL2) is measured. This is a chemokine which recruits monocytes, memory T cells, and dendritic cells to sites of inflammation. GSK620 reduces the MCP-1 response in a concentration-dependent manner with (an expected) ~1 log drop off in potency relative to the biochemical BRD4 BD2 potencies observed[1]. Highlighting the utility of GSK620 as an in vivo tool, efficacy is observed in separate models of inflammatory arthritis, psoriasis, and hepatitis[1].

References

[1]. Seal JT, et al. The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor. J Med Chem. 2020;63(17):9093-9126.

GSK620 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK620 Suppliers

Heze Development Zone chuangli Chemical Co., Ltd.
Tel
+86-530-529 6766,+86-15666160102 15666160102
Fax
0530-529 6766
Email
info@chuangli-chem.com
Country
China
ProdList
869
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9708
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58
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
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62
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
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China
ProdList
2986
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58
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
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China
ProdList
9833
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58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
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China
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9242
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Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Country
China
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Changzhou Extraordinary Pharmatech co., LTD.
Tel
+86-519-82111935 15195055733
Fax
051982611250
Email
info@feifanchem.com
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China
ProdList
362
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58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
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9412
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58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
0519-85788828 13775037613
Email
sales@chemrenpharm.com
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China
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3574
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ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
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3525679403@qq.com
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China
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Zhengzhou convergence chemical co., LTD
Tel
0371-0371-55153829 18003835034
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18003835034(微信)
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2853979819@qq.com
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China
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Wuhan Augda Biotechnology Co., Ltd
Tel
15071299552
Fax
QQ:262933239
Email
262933239@qq.com
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China
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InvivoChem
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13549236410
Email
sales@invivochem.cn
Country
China
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6749
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Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
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China
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18488
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TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
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China
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24017
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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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024-024-88590548 18341751992
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757984502@qq.com
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China
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Wuhan Jingkangen Biomedical Technology Co., Ltd
Tel
13720134139 13720134139
Email
orders@jknbiochem.com
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China
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5280
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Changzhou Ruikaijia polymer material Technology Co., LTD
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3693241975
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kairuijiabio@126.com
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China
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Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
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China
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5141
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb5@aikonchem.com
Country
China
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10529
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https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
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China
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29990
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
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China
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
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China
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48467
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Changsha Fuzhen Biotechnology Co.,LTD
Tel
0731-18670069958 18670069958
Email
184792226@qq.com
Country
China
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3060
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58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
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58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd
Tel
17316404525
Email
209533805@qq.com
Country
China
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9620
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ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
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32715
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Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel
+8613720134139
Email
orders@jknbiochem.com
Country
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LEAPCHEM CO., LTD.
Tel
+86-852-30606658
Email
market18@leapchem.com
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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel
+86-18341751992 +86-15382112998
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Wuhan Topule Biopharmaceutical Co., Ltd
Tel
+8618327326525
Email
masar@topule.com
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China
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Wuhan Nutra Biotechnology Co.,Ltd
Tel
+8617786394783
Email
nutrabiotech@outlook.com
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China
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300
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Shenzhen Shengda Pharma Limited
Tel
755-85269922 +8613424394241
Fax
WeChat:shengdapharm
Email
sales@shengdapharm.com
Country
CHINA
ProdList
310
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View Lastest Price from GSK620 manufacturers

Wuhan Nutra Biotechnology Co.,Ltd
Product
GSK620 2088410-46-0
Price
US $1.00/box
Min. Order
1box
Purity
98%
Supply Ability
1
Release date
2022-11-19

2088410-46-0, GSK620Related Search:


  • GSK620
  • 1-benzyl-N5-cyclopropyl-N3-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxamide
  • Inhibitor,oral,GSK 620,phenotype,selectivity,GSK-620,whole,anti-inflammatory,GSK620,Epigenetic Reader Domain,inhibit,human,blood
  • 3,5-Pyridinedicarboxamide, N5-cyclopropyl-1,2-dihydro-N3-methyl-2-oxo-1-(phenylmethyl)-
  • 2088410-46-0
  • API