6-BROMO-5-METHYL (1H)INDAZOLE
Uses- Product Name
- 6-BROMO-5-METHYL (1H)INDAZOLE
- CAS No.
- 1000343-69-0
- Chemical Name
- 6-BROMO-5-METHYL (1H)INDAZOLE
- Synonyms
- 6-broMo-5-Methyl indazole;6-BROMO-5-METHYL (1H)INDAZOLE;1H-Indazole, 6-broMo-5-Methyl-;7-(Methanesulfonyl)ethylsuccinimidyl
- CBNumber
- CB4807089
- Molecular Formula
- C8H7BrN2
- Formula Weight
- 211.06
- MOL File
- Mol file
6-BROMO-5-METHYL (1H)INDAZOLE Property
- Boiling point:
- 344.6±22.0 °C(Predicted)
- Density
- 1.654
- storage temp.
- 2-8°C(protect from light)
- pka
- 13.01±0.40(Predicted)
- form
- powder
- color
- Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B679213
- Product name
- 6-Bromo-5-methyl-1H-indazole
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B11345
- Product name
- 6-Bromo-5-methyl-1H-indazole
- Purity
- 96%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- HCH0352536
- Product name
- 6-BROMO-5-METHYL-1H-INDAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.58
- Updated
- 2021/12/16
- Product number
- OR30743
- Product name
- 6-Bromo-5-methyl-1H-indazole
- Packaging
- 1g
- Price
- $102
- Updated
- 2021/12/16
- Product number
- X8463
- Product name
- 6-Bromo-5-methyl-1H-indazole
- Packaging
- 250mg
- Price
- $111
- Updated
- 2021/12/16
6-BROMO-5-METHYL (1H)INDAZOLE Chemical Properties,Usage,Production
Uses
6-Bromo-5-chloro-1H-indazole is a fine chemical raw material that can be used as a pharmaceutical intermediate.
Synthesis
69383-60-4
1000343-69-0
The general procedure for the synthesis of 6-bromo-5-methyl-1H-indazole from 5-bromo-2,4-dimethylaniline was as follows: to a solution of 5-bromo-2,4-dimethylaniline (15.09 g, 75.0 mmol) in chloroform (150 mL) was added sequentially, under ice-bath conditions, acetic anhydride (Ac2O, 15.0 g, 150 mmol), potassium acetate (KOAc. 8.009 g, 82.5 mmol), 18-crown-6 (10.0 g, 37.5 mmol) and isoamyl nitrite (26.3 g, 225 mmol). The reaction mixture was heated to reflux for 36 hours. After completion of the reaction, the reaction mixture was concentrated and the residue was dissolved in ethyl acetate (EtOAc, 500 mL). The organic phase was washed with water (100 mL), dried over anhydrous sodium sulfate (Na2SO4) and concentrated. The residue was dissolved in tetrahydrofuran (THF, 100 mL) and sodium hydroxide solution (4 M, 40.0 mL, 160 mmol) was added. After stirring for 1 h at room temperature, the solvent was removed under reduced pressure. The residue was partitioned between ethyl acetate (400 mL) and water (200 mL). The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated. The crude product was purified by column chromatography (petroleum ether: ethyl acetate, gradient elution from 10:1 to 5:1) to afford 6-bromo-5-methyl-1H-indazole (5.1 g, 32% yield) as an orange solid.1H NMR (300 MHz, CDCl3): δ 10.20 (brs, 1H), 7.99 (s, 1H), 7.75 (s, 1H) 7.61 (s, 1H), 2.50 (s, 3H).
References
[1] Patent: WO2017/12576, 2017, A1. Location in patent: Page/Page column 68
[2] Patent: WO2018/137619, 2018, A1. Location in patent: Page/Page column 52; 53; 57; 58; 76
[3] Patent: WO2018/137618, 2018, A1. Location in patent: Page/Page column 50; 60; 61
[4] Patent: WO2018/137573, 2018, A1. Location in patent: Page/Page column 45; 46
[5] Patent: WO2018/137607, 2018, A1. Location in patent: Page/Page column 42-43
6-BROMO-5-METHYL (1H)INDAZOLE Preparation Products And Raw materials
Raw materials
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View Lastest Price from 6-BROMO-5-METHYL (1H)INDAZOLE manufacturers
- Product
- 6-BROMO-5-METHYL (1H)INDAZOLE 1000343-69-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11