ChemicalBook > CAS DataBase List > 4-(2-METHOXYETHOXY)ANILINE

4-(2-METHOXYETHOXY)ANILINE

Product Name
4-(2-METHOXYETHOXY)ANILINE
CAS No.
33311-29-4
Chemical Name
4-(2-METHOXYETHOXY)ANILINE
Synonyms
AKOS BBB/095;AKOS BC-2489;ALINDA 102942;ASISCHEM C40525;CHEMBRDG-BB 4003841;4-(2-Methoxyethoxy);p-Phenetidine, β-methoxy-;4-(2-METHOXYETHOXY)ANILINE;4-(2-methoxyethoxy)phenylamine;4-(2-Methoxyethoxy)-benzenaMine
CBNumber
CB4833691
Molecular Formula
C9H13NO2
Formula Weight
167.21
MOL File
33311-29-4.mol
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4-(2-METHOXYETHOXY)ANILINE Property

Boiling point:
142 °C(Press: 3 Torr)
Density 
1.078±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
5.10±0.10(Predicted)
Appearance
Light brown to brown Solid
InChI
InChI=1S/C9H13NO2/c1-11-6-7-12-9-4-2-8(10)3-5-9/h2-5H,6-7,10H2,1H3
InChIKey
DIOBEQCFVVJJBU-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(OCCOC)C=C1
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2922290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
M304278
Product name
4-(2-Methoxyethoxy)aniline
Packaging
250mg
Price
$70
Updated
2021/12/16
Matrix Scientific
Product number
022417
Product name
4-(2-Methoxyethoxy)aniline
Packaging
500mg
Price
$50
Updated
2021/12/16
Matrix Scientific
Product number
022417
Product name
4-(2-Methoxyethoxy)aniline
Packaging
1g
Price
$77
Updated
2021/12/16
AK Scientific
Product number
Z4603
Product name
4-(2-Methoxyethoxy)aniline
Packaging
250mg
Price
$116
Updated
2021/12/16
AK Scientific
Product number
Z4603
Product name
4-(2-Methoxyethoxy)aniline
Packaging
10g
Price
$537
Updated
2021/12/16
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4-(2-METHOXYETHOXY)ANILINE Chemical Properties,Usage,Production

Synthesis

22483-40-5

33311-29-4

General procedure for the synthesis of 4-(2-methoxyethoxy)aniline from 4-nitrophenyl-2-methoxyethyl ether: 1-(2-methoxyethoxy)-4-nitrobenzene (38) (3.9 g, 20 mmol), methanol (80 mL), and 10% activated carbon (400 mg) were added to a hydrogenation reactor. The reaction mixture was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the mixture was filtered through diatomaceous earth to remove the activated carbon. The filtrate was concentrated in vacuum to afford 4-(2-methoxyethoxy)aniline (39) (3.1 g, 93% yield) as a black oily product. m/z (M+1) 168.1 was shown by LC-MS (ESI) analysis.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 21, p. 5177 - 5181
[2] Patent: CN103864792, 2017, B. Location in patent: Paragraph 0313; 0314; 0315; 0316
[3] Patent: WO2015/131080, 2015, A1. Location in patent: Paragraph 00768; 00770
[4] Patent: WO2014/130693, 2014, A1. Location in patent: Paragraph 00544; 00547
[5] European Journal of Medicinal Chemistry, 1980, vol. 15, # 5, p. 399 - 404

4-(2-METHOXYETHOXY)ANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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