ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE
- Product Name
- ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE
- CAS No.
- 34127-22-5
- Chemical Name
- ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE
- Synonyms
- ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE;3,6-Dichloro-5-ethylpyridazine-4-carbaldehyde;3,6-Dichloropyridazine-4-carboxylic acid ethyl ester;4-Pyridazinecarboxylic acid, 3,6-dichloro-, ethyl ester;ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE ISO 9001：2015 REACH
- CBNumber
- CB4836667
- Molecular Formula
- C7H6Cl2N2O2
- Formula Weight
- 221.04
- MOL File
- 34127-22-5.mol
ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Property
- Boiling point:
- 364.2±37.0 °C(Predicted)
- Density
- 1.433±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- -3.52±0.10(Predicted)
- Appearance
- Light yellow to brown Solid-Liquid Mixture
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- E940718
- Product name
- Ethyl3,6-Dichloropyridazine-4-carboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-W020493
- Product name
- Ethyl3,6-dichloropyridazine-4-carboxylate
- Packaging
- 5g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- CS-W020493
- Product name
- Ethyl3,6-dichloropyridazine-4-carboxylate
- Packaging
- 10g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- HCH0351097
- Product name
- ETHYL-3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.98
- Updated
- 2021/12/16
- Product number
- 4065AB
- Product name
- Ethyl3,6-dichloropyridazine-4-carboxylate
- Packaging
- 10g
- Price
- $523
- Updated
- 2021/12/16
ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
64-17-5
51149-08-7
34127-22-5
To a suspension of 3,6-dichloropyridazine-4-carboxylic acid (15.0 g, 78 mmol) in tetrahydrofuran (THF, 150 mL) was sequentially added ethanol (18.15 mL, 311 mmol) and 4-dimethylaminopyridine (DMAP, 0.950 g, 7.77 mmol). 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC, 16.39 g, 85 mmol) was added in batches over 1 min, and mild exothermic phenomena were observed during the reaction. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the mixture was transferred to a dispensing funnel and neutralized by adding saturated aqueous sodium bicarbonate (NaHCO3) solution (150 mL). The aqueous phase was extracted with ether (3×250 mL), and the combined organic phases were washed with saturated saline (100 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 20%→40% ethyl acetate/hexane solution; amount of silica gel: 300 g) to afford ethyl 3,6-dichloro-4-pyridazine-carboxylate (13.2 g, 59.7 mmol, 77% yield) as a colorless oil. The product was characterized as follows: 1H NMR (400 MHz, CDCl3) δ 7.88 (s, 1H), 4.50 (q, J = 7.0 Hz, 2H), 1.46 (t, J = 7.2 Hz, 3H); LCMS (ESI) m/e 221.1 [(M + H)+, theoretical value 221.0 (C7H7Cl2N2O2)].
References
[1] Patent: WO2018/98411, 2018, A1. Location in patent: Page/Page column 20; 21; 23; 24; 68; 69
[2] Patent: WO2008/130951, 2008, A1. Location in patent: Page/Page column 81
[3] Journal of Medicinal Chemistry, 1993, vol. 36, # 18, p. 2676 - 2688
[4] Patent: WO2008/130600, 2008, A2. Location in patent: Page/Page column 70
[5] Patent: WO2004/108707, 2004, A1. Location in patent: Page 53-54
ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Suppliers
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- United States
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View Lastest Price from ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE manufacturers
- Product
- Ethyl 3,6-dichloropyridazine-4-carboxylate 34127-22-5
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-08-07
- Product
- 3,6-Dichloropyridazine-4-carboxylic acid ethyl ester 34127-22-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 50kgs/month
- Release date
- 2021-11-13
- Product
- ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE 34127-22-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-09