Dasatinib monohydrate

Product Name: Dasatinib monohydrate
CAS No.: 863127-77-9
Chemical Name: Dasatinib monohydrate
Synonyms: Sprycel;Dasatinib hydrate;mmbf;CS-295;Dastinib;Dasatinib R;Bms 35482503;Unii-rbz1571X5h;Dasatinib(TINIBS);Dasatinib(Sprycel)
CBNumber: CB4844484
Molecular Formula: C22H28ClN7O3S
Formula Weight: 506.02
MOL File: 863127-77-9.mol

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Dasatinib monohydrate Property

Melting point:: >223° (dec.)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
InChIKey: XHXFZZNHDVTMLI-UHFFFAOYSA-N
SMILES: N(C1=NC=C(C(=O)NC2C(=CC=CC=2C)Cl)S1)C1N=C(C)N=C(N2CCN(CCO)CC2)C=1.O
CAS DataBase Reference: 863127-77-9(CAS DataBase Reference)

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H360May damage fertility or the unborn child

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P281Use personal protective equipment as required.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D193638
Product name: DasatinibMonohydrate
Packaging: 250mg
Price: $50
Updated: 2021/12/16

TRC

Product number: D193638
Product name: DasatinibMonohydrate
Packaging: 500mg
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD10821
Product name: Dasatinib monohydrate
Packaging: 500mg
Price: $80
Updated: 2021/12/16

ApexBio Technology

Product number: B5954
Product name: DasatinibMonohydrate
Packaging: 500mg
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: J11235
Product name: Dasatinibmonohydrate
Packaging: 25mg
Price: $49
Updated: 2021/12/16

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Dasatinib monohydrate Chemical Properties,Usage,Production

Uses

antineoplastic

Uses

Dasatinib Monohydrate is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. It is a COVID19-related research product.

Definition

Dasatinib monohydrate is a hydrate that is the monohydrate of dasatinib. It is used for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN； dasatinib monohydrate) as well as to anhydrous dasatinib (INN). It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It contains a dasatinib (anhydrous).

brand name

Sprycel (Bristol-Myers Squibb).

Biological Activity

chronic myeloid leukemia (cml) is a disease characterized by the presence of the philadelphia (ph+) chromosome and its oncogenic product, bcr-abl, that is present in >90% of the patients. dasatinib (bms-354825) is a novel, potent, and multitargeted kinase inhibitor that targets abl, src, kit, pdgfr, and other tyrosine kinases.

in vitro

dasatinib is a potent atp-competitive inhibitor in biochemical assays with broad-spectrum antiproliferative activities against hematological and solid tumor cell lines. dasatinib was more potent than imatinib at inhibiting nonmutated bcr-abl kinase activity. in addition, the kinase activity of 14 out of 15 different clinically relevant, imatinib-resistant bcr-abl isoforms was successfully inhibited [1].

in vivo

mice were dosed with dasatinib or vehicle alone by gavage for 2 weeks, beginning 3 days after injection of ba/f3 cells. all vehicle-treated mice developed progressive disease. in contrast, dasatinib–treated mice harboring nonmutant bcr-abl or the clinically common imatinib-resistant mutation m351t appeared healthy with no evidence of weight loss, lethargy, or ruffled fur and showed more than one log lower levels of bioluminescent activity after 2 weeks of therapy [2].

IC 50

0.55 and 3.0 nm for src and bcr-abl tyrosine kinases, respectively

References

[1] shah np, tran c, lee fy, chen p, norris d, sawyers cl. overriding imatinib resistance with a novel abl kinase inhibitor. science. 2004 jul 16;305(5682):399-401.
[2] monika conchon, carla maria boquimpani de moura freitas, maria aparecida do carmo rego, and josé wilson ramos braga junior. dasatinib -

Dasatinib monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Dasatinib monohydrate Suppliers

China 387 Europe 2 Germany 2 India 22 Israel 2 South Korea 1 United Kingdom 12 United States 26 Global 454

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View Lastest Price from Dasatinib monohydrate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Dasatinib Monohydrate 863127-77-9
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-16

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Dasatinib monohydrate 863127-77-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-13

Nanjing Fred Technology Co., Ltd

Product: Dasatinib monohydrate 863127-77-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%, Single impurity＜0.1
Supply Ability: 1 ton
Release date: 2023-12-20

863127-77-9, Dasatinib monohydrateRelated Search:

Erlotinib Teniposide 2-(METHYLSULFONYL)ETHANOL Gefitinib Lapatinib Sunitinib 2-Ethylhexyl ferulate N-Aminoethylpiperazine MELIBIOSE Imatinib 3,4'-DIAMINODIPHENYLMETHANE Dasatinib N-O impurity Dasatinib impurity 28 Dasatinib impurity 29 Epichlorohydrin Dasatinib Chloroacetic acid Difluorochloromethane

Dasatinib R

BMS-354825 Monohydrate

N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide hydrate

Dasatinib monohydrate N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate

Dasatinib monohydrate, >=99%

dasatinib monohydrate

5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-, hydrate (1:1)

n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-

mmbf

Dasatinib(TINIBS)

Dastinib

Bms 35482503

Dasatinib hydrate

Sprycel

Unii-rbz1571X5h

n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate

n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide

CS-295

Dasatinib(Sprycel)

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide,hydrate

asatinib monohydrate

Dasatinib monohydrate USP/EP/BP

DasatinibmonohydrateDasatinib

Dasatinib Monohydrate (BMS354825

Dasatinib Monohydrate intermediate

Dashatini monohydrate

Dasatinib (monohydrate) (Dasatinib Impurity)

Dashatinib monohydrate

863127-77-9

863121-77-9

C22H26CIN7O2SH2O

C22H26ClN7O2SH2O

Inhibitors

API

Anti-cancer&immunity

SPRYCEL

Molecular Targeted Antineoplastic

Pharmaceutical

863127-77-9