ChemicalBook > CAS DataBase List > 2,6-Difluorophenylboronic acid

2,6-Difluorophenylboronic acid

Product Name
2,6-Difluorophenylboronic acid
CAS No.
162101-25-9
Chemical Name
2,6-Difluorophenylboronic acid
Synonyms
2,6-DIMETHOXYBENZENEBORONIC ACID;2,6-Difluorophenylboronic;AKOS BRN-0146;AKOS BRN-0261;CAS:162101-25-9;CHEMBRDG-BB 3200972;RARECHEM AH PB 0108;TIMTEC-BB SBB003736;RARECHEM AH PB 0164;2,6-Difluorophenylbo
CBNumber
CB4853172
Molecular Formula
C6H5BF2O2
Formula Weight
157.91
MOL File
162101-25-9.mol
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2,6-Difluorophenylboronic acid Property

Melting point:
147-149 °C (lit.)
Boiling point:
260.1±50.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in methanol.
form 
solid
pka
8.12±0.58(Predicted)
color 
White to Almost white
BRN 
8545931
InChI
InChI=1S/C6H5BF2O2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3,10-11H
InChIKey
DBZAICSEFBVFHL-UHFFFAOYSA-N
SMILES
B(C1=C(F)C=CC=C1F)(O)O
CAS DataBase Reference
162101-25-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
470791
Product name
2,6-Difluorophenylboronic acid
Purity
98%
Packaging
1g
Price
$29.89
Updated
2025/07/31
Sigma-Aldrich
Product number
470791
Product name
2,6-Difluorophenylboronic acid
Purity
98%
Packaging
10g
Price
$250
Updated
2025/07/31
TCI Chemical
Product number
D3087
Product name
2,6-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$24
Updated
2025/07/31
TCI Chemical
Product number
D3087
Product name
2,6-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$70
Updated
2025/07/31
TCI Chemical
Product number
D3087
Product name
2,6-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
25g
Price
$210
Updated
2025/07/31
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2,6-Difluorophenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline powder

Uses

suzuki reaction

Uses

2,6-Difluorophenylboronic acid can be used:

  • As a substrate in the model reaction of Suzuki–Miyaura coupling with?4-chloro-3-methylanisole.
  • To prepare 4-bromo-2,3′,5′,6-tetrafluorobiphenyl, a key intermediate for the synthesis of 2,6-difluorinated oligophenyls applicable in organic semiconductors.
  • To prepare ethyl 4-(2,6-difluorophenyl)nicotinate, a key intermediate for the synthesis of 4-phenyl pyridine based potent TGR5 agonists.

Uses

Intermediates of Liquid Crystals

Synthesis

121-43-7

372-18-9

162101-25-9

The general procedure for the synthesis of 2,6-difluorophenylboronic acid from trimethyl borate and 1,3-difluorobenzene was as follows: 22.8 g of 1,3-difluorobenzene (Compound I) and 150 mL of anhydrous ethyl ether were added to a 500 mL dry reaction flask under nitrogen protection and the system was cooled to -78 °C. Slowly 187 mL of 1.6 M n-butyllithium hexane solution was added dropwise to the mixture. After the dropwise addition was completed, the reaction was stirred at -60 to -70 °C for 2 hours. The system was again cooled to -78°C and 60 g of trimethyl borate was slowly added dropwise, and after the dropwise addition was completed, the reaction was stirred at a controlled temperature of -50 to -60°C for 2 hours. The reaction mixture was slowly warmed to room temperature, the reaction was quenched by the addition of 200 mL of water and acidified with 36% hydrochloric acid. After recovering the organic solvent by ascending distillation, the reaction mixture was stirred at 70 to 80 °C for 6 hours. Finally, the system was cooled to crystallization, filtered and washed with cold water to afford 27.0 g of 2,6-difluorophenylboronic acid (Compound II).

References

[1] Patent: CN103819401, 2016, B. Location in patent: Paragraph 0023; 0066; 0067

2,6-Difluorophenylboronic acid Preparation Products And Raw materials

Raw materials

1-Bromo-2,6-difluorobenzene Diethyl ether Triisopropyl borate n-Butyllithium

Preparation Products

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2,6-Difluorophenylboronic acid Suppliers

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View Lastest Price from 2,6-Difluorophenylboronic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2,6-Difluorophenylboronic acid 162101-25-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30
Hebei Yanxi Chemical Co., Ltd.
Product
2,6-Difluorophenylboronic acid 162101-25-9
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-26
Henan Fengda Chemical Co., Ltd
Product
2,6-Difluorophenylboronic acid 162101-25-9
Price
US $34.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08

162101-25-9, 2,6-Difluorophenylboronic acidRelated Search:

2,3,4,5,6-PENTAFLUOROBENZENEBORONIC ACID 3-Fluorophenylboronic acid Florfenicol Transfluthrin Phenylboronic acid 1,3-Difluorobenzene 4-Fluorobenzeneboronic acid 3,5-DIFLUOROPHENYLBORONIC ACID,3,5-Difluorophenylboronic Acid (contains varying amounts of Anhydride),3,5-DIFLUOROPHENYLBORONIC ACID 98% 4-BROMO-2 6-DIFLUOROPHENYLBORONIC ACID 2,6-Difluoro-3-methoxybenzeneboronic acid 3-Ethoxy-2,6-difluorophenylboronic acid 2,4,6-Trifluorophenylboronic acid 2,6-DIFLUORO-3-ISOPROPOXYPHENYLBORONIC & 3-BROMO-2 6-DIFLUOROPHENYLBORONIC ACID 2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID 2,6-DIFLUORO-3-(3',5'-DIMETHOXYBENZYLOX& 2,3,6-Trifluorophenylboronic acid 2,3,4,6-TETRAFLUOROBENZENEBORONIC ACID

  • BORONICACID, B-(2,6-DIFLUOROPHENYL)-
  • 2,6-Difluorophenylboronic acid 98%
  • RARECHEM AH PB 0108
  • CHEMBRDG-BB 3200972
  • AKOS BRN-0261
  • AKOS BRN-0146
  • 2,6-DIMETHOXYBENZENEBORONIC ACID
  • 2,6-DIFLUORO PHENYLBORIC ACID
  • 2,6-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
  • 2,6-DIFLUOROPHENYLBORONIC ACID
  • 2,6-DIFLUOROBENZENEBORONIC ACID
  • Boronic acid, (2,6-difluorophenyl)- (9CI)
  • 2,6-Difluorophenylboronic
  • 2,6-Difluorobenzeneboronic acid 98%
  • 2,6-Difluorobenzeneboronicacid98%
  • 2,6-Difluoropenylboronic acid
  • 2,6-Difluorophenylboronic acid,97%
  • 2,6-Difluorophenylboronic acid ,98%
  • 2,6-Difluorophenylbo
  • 2,6-Difluorophenylboronic acid, May contain varying amounts of anhydride, 97%
  • 2,6-difluoro boric acid
  • 2,6-Difluorophenylboronic acid, 97% 1GR
  • TIMTEC-BB SBB003736
  • RARECHEM AH PB 0164
  • 2,6-Difluorobenzeneboronic Acid (contains varying amounts of Anhydride)
  • CAS:162101-25-9
  • 6-difluorophenylboronicacid
  • 2,6-Difluorophenylboronic acid - [D2660]
  • 162101-25-9
  • Organometallic Reagents
  • Boronic Acids and Derivatives
  • Aryl
  • BORONIC ACID
  • B (Classes of Boron Compounds)
  • Boronic Acids
  • Organometallic Reagents
  • Boronate Ester
  • Potassium Trifluoroborate
  • Pyridines
  • Aryl Boronic Acids
  • Boronic Acids and Derivatives
  • Chemical Synthesis
  • Disubstituted Aryl Boronic Acids
  • Boronic Acid
  • Substituted Boronic Acids
  • Fluorobenzene
  • Aryl
  • Halogenated
  • Organoborons
  • B (Classes of Boron Compounds)
  • Boronic Acids
  • Boronic Acids
  • Boronic Acids and Derivatives
  • HALIDE
  • blocks
  • BoronicAcids
  • FluoroCompounds
  • bc0001