2,6-Difluorophenylboronic acid
- Product Name
- 2,6-Difluorophenylboronic acid
- CAS No.
- 162101-25-9
- Chemical Name
- 2,6-Difluorophenylboronic acid
- Synonyms
- 2,6-DIMETHOXYBENZENEBORONIC ACID;2,6-Difluorophenylboronic;AKOS BRN-0146;AKOS BRN-0261;CAS:162101-25-9;CHEMBRDG-BB 3200972;RARECHEM AH PB 0108;TIMTEC-BB SBB003736;RARECHEM AH PB 0164;2,6-Difluorophenylbo
- CBNumber
- CB4853172
- Molecular Formula
- C6H5BF2O2
- Formula Weight
- 157.91
- MOL File
- 162101-25-9.mol
2,6-Difluorophenylboronic acid Property
- Melting point:
- 147-149 °C (lit.)
- Boiling point:
- 260.1±50.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in methanol.
- form
- solid
- pka
- 8.12±0.58(Predicted)
- color
- White to Almost white
- BRN
- 8545931
- InChI
- InChI=1S/C6H5BF2O2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3,10-11H
- InChIKey
- DBZAICSEFBVFHL-UHFFFAOYSA-N
- SMILES
- B(C1=C(F)C=CC=C1F)(O)O
- CAS DataBase Reference
- 162101-25-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 470791
- Product name
- 2,6-Difluorophenylboronic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $29.89
- Updated
- 2025/07/31
- Product number
- 470791
- Product name
- 2,6-Difluorophenylboronic acid
- Purity
- 98%
- Packaging
- 10g
- Price
- $250
- Updated
- 2025/07/31
- Product number
- D3087
- Product name
- 2,6-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- D3087
- Product name
- 2,6-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $70
- Updated
- 2025/07/31
- Product number
- D3087
- Product name
- 2,6-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 25g
- Price
- $210
- Updated
- 2025/07/31
2,6-Difluorophenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
White to off-white crystalline powder
Uses
suzuki reaction
Uses
2,6-Difluorophenylboronic acid can be used:
- As a substrate in the model reaction of Suzuki–Miyaura coupling with?4-chloro-3-methylanisole.
- To prepare 4-bromo-2,3′,5′,6-tetrafluorobiphenyl, a key intermediate for the synthesis of 2,6-difluorinated oligophenyls applicable in organic semiconductors.
- To prepare ethyl 4-(2,6-difluorophenyl)nicotinate, a key intermediate for the synthesis of 4-phenyl pyridine based potent TGR5 agonists.
Uses
Intermediates of Liquid Crystals
Synthesis
121-43-7
372-18-9
162101-25-9
The general procedure for the synthesis of 2,6-difluorophenylboronic acid from trimethyl borate and 1,3-difluorobenzene was as follows: 22.8 g of 1,3-difluorobenzene (Compound I) and 150 mL of anhydrous ethyl ether were added to a 500 mL dry reaction flask under nitrogen protection and the system was cooled to -78 °C. Slowly 187 mL of 1.6 M n-butyllithium hexane solution was added dropwise to the mixture. After the dropwise addition was completed, the reaction was stirred at -60 to -70 °C for 2 hours. The system was again cooled to -78°C and 60 g of trimethyl borate was slowly added dropwise, and after the dropwise addition was completed, the reaction was stirred at a controlled temperature of -50 to -60°C for 2 hours. The reaction mixture was slowly warmed to room temperature, the reaction was quenched by the addition of 200 mL of water and acidified with 36% hydrochloric acid. After recovering the organic solvent by ascending distillation, the reaction mixture was stirred at 70 to 80 °C for 6 hours. Finally, the system was cooled to crystallization, filtered and washed with cold water to afford 27.0 g of 2,6-difluorophenylboronic acid (Compound II).
References
[1] Patent: CN103819401, 2016, B. Location in patent: Paragraph 0023; 0066; 0067
2,6-Difluorophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-Difluorophenylboronic acid Suppliers
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View Lastest Price from 2,6-Difluorophenylboronic acid manufacturers
- Product
- 2,6-Difluorophenylboronic acid 162101-25-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-30
- Product
- 2,6-Difluorophenylboronic acid 162101-25-9
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-26
- Product
- 2,6-Difluorophenylboronic acid 162101-25-9
- Price
- US $34.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08