(4R)-4-Methyl-2-oxazolidinone

Product Name: (4R)-4-Methyl-2-oxazolidinone
CAS No.: 4042-43-7
Chemical Name: (4R)-4-Methyl-2-oxazolidinone
Synonyms: (4R)-4-Methyl-2-oxazolidinone;2-Oxazolidinone,4-methyl-,(4S)-;2-Oxazolidinone, 4-methyl-, (4R)-;(4R)-4-Methyl-2-oxazolidinone4042-43-7;Benzenepropanoicacid,6-chloro-β-oxo-,methylester
CBNumber: CB4853602
Molecular Formula: C4H7NO2
Formula Weight: 101.1
MOL File: 4042-43-7.mol

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(4R)-4-Methyl-2-oxazolidinone Property

Melting point:: 45.9 °C
Boiling point:: 302.6±9.0 °C(Predicted)
Density: 1.095±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.84±0.40(Predicted)
Appearance: White to light yellow Solid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M336368
Product name: (R)-4-Methyloxazolidin-2-one
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Activate Scientific

Product number: AS90120
Product name: (R)-4-Methyloxazolidin-2-one
Purity: 95+% ee
Packaging: 250mg
Price: $122
Updated: 2021/12/16

AK Scientific

Product number: 5441AB
Product name: (R)-4-Methyloxazolidin-2-one
Packaging: 250mg
Price: $131
Updated: 2021/12/16

Apolloscientific

Product number: OR938550
Product name: (R)-4-Methyloxazolidin-2-one
Purity: 95%
Packaging: 250mg
Price: $225
Updated: 2021/12/16

Activate Scientific

Product number: AS90120
Product name: (R)-4-Methyloxazolidin-2-one
Purity: 95+% ee
Packaging: 1g
Price: $281
Updated: 2021/12/16

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(4R)-4-Methyl-2-oxazolidinone Chemical Properties,Usage,Production

Synthesis

75-44-5

35320-23-1

4042-43-7

D-alaninol (8.65 g, 0.12 mmol) was dissolved in a mixed solvent of toluene and KOH aqueous solution (124 mL, 12.5% aqueous solution, 0.28 mmol) at 0 °C. Phosgene (72.7 mL, 20% toluene solution, 0.14 mmol) was added slowly dropwise, and the dropwise acceleration was controlled to maintain the internal temperature of the reaction system below 5 °C. After the dropwise addition, the reaction was continued to be stirred at 0 °C for 40 min. After completion of the reaction, the reaction mixture was concentrated to dryness under reduced pressure. The crude product was dissolved with industrial methanol, filtered to remove insoluble matter, and the filtrate was concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel fast column chromatography (eluent gradient: 40-100% cyclohexane solution of ethyl acetate), and 10.4 g (90% yield) of (R)-4-methyl-2-oxazolidinone was finally obtained as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 6.00 (broad single peak, 1H), 4.50 (triple peak, J=6.5 Hz, 1H), 4.07-3.97 (multiple peaks, 1H), 3.95 (double dichotomous peaks, J=7.8,6.2 Hz, 1H), and 1.30 (dichotomous peak, J=6.1 Hz, 3H).

References

[1] Patent: WO2017/1645, 2017, A1. Location in patent: Page/Page column 78; 79
[2] Patent: US2017/2022, 2017, A1. Location in patent: Paragraph 0185-0186

(4R)-4-Methyl-2-oxazolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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(4R)-4-Methyl-2-oxazolidinone Suppliers

China 47 India 2 United States 5 Global 54

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Hangzhou Molcore Biopharmatech Co.,Ltd

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View Lastest Price from (4R)-4-Methyl-2-oxazolidinone manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: (4R)-4-Methyl-2-oxazolidinone 4042-43-7
Price: US $3.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-07-29

4042-43-7, (4R)-4-Methyl-2-oxazolidinoneRelated Search:

(R)-(-)-3-PROPIONYL-4-ISOPROPYL-2-OXAZOLIDINONE (-)-CHIRACAMPHOX (N-CHLOROACETYL)-(4S)-BENZYL-2-OXAZOLIDINONE (R)-(-)-4-Phenyl-2-oxazolidinone (R)-(+)-4-Isopropyl-2-oxazolidinone (4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE (R)-4-Benzyl-2-oxazolidinone (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE N-PROPIONYL-(4S,5R)-4-METHYL- 5-PHENYL-2-OXAZOLIDINONE N-ACETYL-(4R)-ISOPROPYL 2-OXAZOLIDINONE (R)-(-)-5,5-DIMETHYL-4-PHENYL-2-OXAZOLIDINONE N-ACETYL-(4S,5R)-4-METHYL 5-PHENYL-2-OXAZOLIDINONE N-CROTONYL-(4R,5S)-4-METHYL 5-PHENYL-2-OXAZOLIDINONE (N-ACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE Z-D-Phenylalanine N-carboxyanhydride (R)-(+)-4-BENZYL-5,5-DIMETHYL-2-OXAZOLIDINONE 3-BROMO-4,4-DIMETHYL-2-OXAZOLIDINONE N-(DIETHYLPHOSPHONOACETYL) (4R)-BENZYL-2-OXAZOLIDINONE

(4R)-4-Methyl-2-oxazolidinone

(4R)-4-Methyl-2-oxazolidinone4042-43-7

2-Oxazolidinone, 4-methyl-, (4R)-

2-Oxazolidinone,4-methyl-,(4S)-

Benzenepropanoicacid,6-chloro-β-oxo-,methylester

4042-43-7