Chemical properties Uses Production methods Hazards & Safety Information
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Thioacetic acid

Chemical properties Uses Production methods Hazards & Safety Information
Product Name
Thioacetic acid
CAS No.
507-09-5
Chemical Name
Thioacetic acid
Synonyms
TAA;Ethanethioic S-acid;THIOLACETIC ACID;CH3COSH;thioacetic;ethanethioic O-acid;ETHANETHIOIC ACID;liudaiyisuan;THIOESSIGSAEURE;thionoaceticacid
CBNumber
CB4853697
Molecular Formula
C2H4OS
Formula Weight
76.12
MOL File
507-09-5.mol
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Thioacetic acid Property

Melting point:
-17 °C
Boiling point:
97 °C
Density 
1.065 g/mL at 25 °C(lit.)
vapor pressure 
1 hPa (20 °C)
FEMA 
4210 | THIOACETIC ACID
refractive index 
n20/D 1.465(lit.)
Flash point:
52 °F
storage temp. 
Store below +30°C.
solubility 
27g/l (slow decomposition)
form 
Liquid
pka
3.33(at 25℃)
color 
Clear colorless to pale yellow
PH
1.8 (100g/l, H2O, 20℃)Hydrolysis
Odor
at 0.01 % in propylene glycol. cooked roasted meaty burnt
Odor Type
meaty
Water Solubility 
27 g/L (15 ºC) (hydrolyse)
Merck 
14,9320
JECFA Number
1676
BRN 
773684
Dielectric constant
13.0（20℃）
Stability:
Stable. Flammable. Incompatible with metals, strong oxidizing agents.
LogP
0.14
CAS DataBase Reference
507-09-5(CAS DataBase Reference)
NIST Chemistry Reference
Ethanethioic acid(507-09-5)
EPA Substance Registry System
Ethanethioic acid (507-09-5)
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Safety

Hazard Codes 
F,C,Xn
Risk Statements 
11-34-22-43-41
Safety Statements 
9-16-26-36/37/39-45-28-23
RIDADR 
UN 2436 3/PG 2
WGK Germany 
3
RTECS 
AJ5600000
F 
13-19
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29309070
Toxicity
LD50 orally in Rabbit: 200 - 350 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H301Toxic if swalloed

H317May cause an allergic skin reaction

H318Causes serious eye damage

H332Harmful if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T30805
Product name
Thioacetic acid
Purity
96%
Packaging
5g
Price
$32
Updated
2024/03/01
Sigma-Aldrich
Product number
T30805
Product name
Thioacetic acid
Purity
96%
Packaging
100g
Price
$63.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08076
Product name
Thioacetic acid
Purity
for synthesis
Packaging
100mL
Price
$71.9
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08076
Product name
Thioacetic acid
Purity
for synthesis
Packaging
250ML
Price
$159
Updated
2024/03/01
TCI Chemical
Product number
T0189
Product name
Thioacetic Acid
Purity
>95.0%(GC)
Packaging
25mL
Price
$24
Updated
2024/03/01
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Thioacetic acid Chemical Properties,Usage,Production

Chemical properties

Thioacetic acid is acid containing thiol group, it is also known as thioacetate, thiol acetic acid, acetic acid. It is yellow fuming liquid with unpleasant and pungent odor, chemical property is active, reactivity is very strong, it can prapare mercaptan by reaction with unsaturated aliphatic hydrocarbon and alcohol.
CH3COSH + CH2 = CHCH3 → CH3CH2CH2SH
CH3COSH + CH3CH2OH → CH3CH2SH
Reaction with ethylene oxide can prepare acetylthio ethanol.
CH3COSH + (CH2) 2O → CH3COSCH2CH2OH
Four methods of laboratory prepared thioacetic acid:
1, acetic acid and phosphorus pentasulfide at 91℃ react, vacuum distillation is further refined and product can obtain.
5CH3COOH + P2S5 → CH3COSHC2H4OS + P2O5
2, chloride and hydrogen sulfide react, after dilute lye neutralizes and distillation refines. It can be obtained.
3, the reaction of acetic anhydride with hydrogen sulfide, thioacetic acid can be obtained, while byproduct of acetic acid can get.
4, the reaction of ketene with hydrogen sulfide can directly obtain.
Uses: In laboratory, it can instead of hydrogen sulfide, it can be used verification of cobalt and lead, determination of molybdenum, sulfur synthetic aldehydes and ketones sulfur, histochemical determination of esterase, it can be used as tear gas and so on.

Uses

1. This product can be used as organic synthesis acetylthio agent and mercapto agent, it is mainly used for lipoic acid, cystine and synthetic mercapto carboxylic acids, it can also be used for hormone antidote, cephalosporins sex and fungicides, modifiers and additives for synthetic polymers. For reagents, flavors and fragrances, cosmetics, synthetic captopril.
2. It can be used as pharmaceuticals, flavors and fragrances intermediates.
3. It can be used as chemical reagent, precipitation agent and catalyst.

Production methods

It can be obtained by thermal distillation of ice aldehyde acid with five-thiodipropionic phosphorus. Finely powdered phosphorus pentasulfide is added into glacial acetic acid. When heated to 91℃, it start distilles thioacetic acid, it need to prevent bumping during heating, distillation temperature must not exceed 100 ℃. Distillate distilles once again can derive product.

Hazards & Safety Information

Category: corrosive materials
Toxicity grading: highly toxic Acute intraperitoneal toxicity-mouse LD50: 75 mg/kg
Flammability Combustible hazardous characteristics: it is combustible, easy to decompose into acetic acid and toxic hydrogen sulfide gas
Storage characteristics: Treasury ventilation low-temperature drying; and it should be stored separately with oxidants, alkali.
Extinguishant: sand, foam, water spray, carbon dioxide.

Chemical Properties

colourless fuming liquid with an unpleasant odour

Chemical Properties

Pale yellow liquid; cooked brown and roasted meat aroma.

Uses

Thioacetic acid is a reagent for introduction of the thiol group into organic molecules. It is used as flavor & Fragrance Intermediates. It is used to manufacture captopril(antihypertension) and spironolac-tone (diuretic).

Uses

Chemical reagent, lachrymator.

Definition

ChEBI: A thioacetic acid that is acetic acid in which the oxygen atom of the hydroxy group has been replaced by a sulfur atom.

General Description

A clear,yellow liquid with a strong, unpleasant odor. May be toxic by ingestion, inhalation and skin absorption. Irritating to skin and eyes. Flash point near 50°F. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Water soluble.

Reactivity Profile

Thioacetic acid is a thio organic acid. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid.

Hazard

Toxic by ingestion and inhalation; strong irritant to eyes and skin.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Highly flammable

Safety Profile

Poison by intraperitoneal route. A very dangerous fire hazard when exposed to heat or flame. When heated to decomposition it emits toxic fumes of SOx. See also SULFIDES and MERCAPTANS.

Thioacetic acid Preparation Products And Raw materials

Raw materials

Sodium sulfide nonahydrate Acetic anhydride Sodium sulfide Phosphorus pentasulfide Sulfuric acid

Preparation Products

Mercaptosuccinic acid 1,3-DIMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID Captopril brotianide Isobutyryl chloride Dimercaptosuccinic acid
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Thioacetic acid Suppliers

Australia 1 Belgium 2 Canada 1 Chile 1 China 237 Europe 2 France 1 Germany 7 India 24 Japan 9 Poland 1 Slovakia 1 South Korea 1 Switzerland 5 Ukraine 1 United Kingdom 11 United States 42 Global 347
Standardpharm Co. Ltd.
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View Lastest Price from Thioacetic acid manufacturers

Shanghai Bojing Chemical Co.,Ltd.
Product
Thioacetic Acid 507-09-5
Price
US $0.00-0.00/kg
Min. Order
25kg
Purity
99%
Supply Ability
100MT/month
Release date
2023-12-11
Taixing Foreign Trade Nanjing Co., Ltd.
Product
Thioacetic acid 507-09-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98.0%
Supply Ability
1000t
Release date
2023-09-21
Hebei Zhanyao Biotechnology Co. Ltd
Product
Thioacetic Acid 507-09-5
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-15

507-09-5, Thioacetic acidRelated Search:

Hyaluronic acid Citric acid Folic acid Sodium thiosulfate pentahydrate 2-Thiobarbituric acid Ethyl 2-(Chlorosulfonyl)acetate TAA Ammonium thiosulfate Potassium thioacetate THIOACETIC ACID S-FURFURYL ESTER Thiosalicylic acid Ascoric Acid ACETYL SULFIDE Diethyl benzylmalonate Thiorphan Disulfide DL-THIORPHAN Benzyl glycinate p-toluenesulfonate Deacetyl Racecadotril Disulfide

  • thionoaceticacid
  • Usaf EK-P-737
  • usafek-p-737
  • ThioaceticAcid,>97%
  • EthanthiolicAcid
  • ethylsulfuric acid
  • THIOESSIGSAEURE
  • Thioessigsure
  • thiacetic S-acid
  • Thioycsysic acid
  • liudaiyisuan
  • acetylmercaptan
  • CH3COSH
  • Ethanethioic S-acid
  • Ethanethiolic acid
  • ethanethiolicacid
  • Kyselina thiooctova
  • kyselinathiooctova
  • Methanecarbothiolic acid
  • methanecarbothiolicacid
  • thioacetic
  • thio-aceticaci
  • Thionoacetic acid
  • Thiacetic acid, Thiolacetic acid
  • Thioacetic acid,96%
  • Thiolacetic acid,98%
  • Thioacetic acid ,98%
  • Thiolacetic acid, 98% 100GR
  • ethanethioic O-acid
  • THIOACETIC S-ACID
  • THIOACETIC ACID
  • THIOLACETIC ACID
  • THIACETIC ACID
  • TAA
  • aceticacid,thio-
  • Acetyl mercaptan
  • ETHANETHIOIC ACID
  • ATA(TM)
  • Thioacetic acid, 97.5%
  • Thioacetic Acid 〔Thioacetic S-Acid〕
  • Thioacetic Acid &gt
  • Thioacetic acid ISO 9001：2015 REACH
  • Thioacetic acid CAS NO 507-09-5
  • Racecadotril Impurity 1（Racecadotril EP Impurity A）
  • Racecadotril impurity A CRS
  • Thioacetic Acid, ≥ 95.0%
  • 507-09-5
  • 0507-09-05
  • C2H4OS
  • C2H5OSO2OH
  • Organic Acids
  • Synthetic Reagents
  • Pharmaceutical intermediates