ChemicalBook > CAS DataBase List > 2,4-Dihydroxy-3-methylbenzaldehyde

2,4-Dihydroxy-3-methylbenzaldehyde

Product Name
2,4-Dihydroxy-3-methylbenzaldehyde
CAS No.
6248-20-0
Chemical Name
2,4-Dihydroxy-3-methylbenzaldehyde
Synonyms
Einecs 228-369-5;2,4-Dihydroxy-3-meth;4-Formyl-2-methylresorcinol;4-Dihydroxy-3-methylbenzaldehyde;2,4-Dihydroxy-3-methylbenzaldehyd;4-Hydroxy-3-methylsalicylaldehyde;3-methyl-2,4-dihydroxybenzaldehyde;2,4-dihydroxy-3-methylbenzaldehyde;Benzaldehyde, 2,4-dihydroxy-3-methyl-;2,4-Dihydroxy-3-methylbenzaldehyde in Acetonitrile
CBNumber
CB4855217
Molecular Formula
C8H8O3
Formula Weight
152.15
MOL File
6248-20-0.mol
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2,4-Dihydroxy-3-methylbenzaldehyde Property

Melting point:
150 °C
Boiling point:
345.7±12.0 °C(Predicted)
Density 
1.331±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
7.93±0.23(Predicted)
color 
Light Orange to Light Red
InChI
InChI=1S/C8H8O3/c1-5-7(10)3-2-6(4-9)8(5)11/h2-4,10-11H,1H3
InChIKey
AOPMHYFEQDBXPZ-UHFFFAOYSA-N
SMILES
C(=O)C1=CC=C(O)C(C)=C1O
LogP
1.727 (est)
EPA Substance Registry System
Benzaldehyde, 2,4-dihydroxy-3-methyl- (6248-20-0)
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Safety

Safety Statements 
24/25
HS Code 
29124990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
F700845
Product name
4-Formyl-2-methylresorcinol
Packaging
500mg
Price
$80
Updated
2021/12/16
TRC
Product number
F700845
Product name
4-Formyl-2-methylresorcinol
Packaging
1g
Price
$105
Updated
2021/12/16
TRC
Product number
F700845
Product name
4-Formyl-2-methylresorcinol
Packaging
10g
Price
$580
Updated
2021/12/16
AK Scientific
Product number
J50989
Product name
2,4-Dihydroxy-3-methylbenzaldehyde
Packaging
1g
Price
$16
Updated
2021/12/16
Matrix Scientific
Product number
073893
Product name
2,4-Dihydroxy-3-methylbenzaldehyde
Purity
95+%
Packaging
1g
Price
$35
Updated
2021/12/16
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2,4-Dihydroxy-3-methylbenzaldehyde Chemical Properties,Usage,Production

Uses

4-Formyl-2-methylresorcinol is a reactant in the synthesis of 3-benzo[b]thiophenecoumarin, with potent anti-proliferative activity against breast cancer cell lines

Synthesis

608-25-3

68-12-2

6248-20-0

The general procedure for the synthesis of 3-methyl-2,4-dihydroxybenzaldehyde from 2,6-dihydroxytoluene and N,N-dimethylformamide was as follows: first, N,N-dimethylformamide (6.2 mL, 80.65 mmol) was mixed with phosphorochloride (8.1 mL, 88.61 mmol), followed by the addition of 2-methylresorcinol (5.0 g, 40.3 mmol ) and ethyl acetate (100 mL). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction solution was combined with ethyl acetate, the organic phase was dried with anhydrous sodium sulfate, filtered to remove the desiccant, and the filtrate was subsequently concentrated under reduced pressure. Finally, the target product 3-methyl-2,4-dihydroxybenzaldehyde (4.9 g, 79.9% yield) was purified by silica gel column chromatography.

References

[1] Organic and Biomolecular Chemistry, 2005, vol. 3, # 12, p. 2305 - 2309
[2] Chemistry - An Asian Journal, 2010, vol. 5, # 1, p. 130 - 140
[3] Patent: CN106957279, 2017, A. Location in patent: Paragraph 0042; 0049; 0050; 0051
[4] Tetrahedron Letters, 2000, vol. 41, # 11, p. 1741 - 1745
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 42, p. 12888 - 12891

2,4-Dihydroxy-3-methylbenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-Dihydroxy-3-methylbenzaldehyde manufacturers

Career Henan Chemical Co
Product
2,4-Dihydroxy-3-methylbenzaldehyde 6248-20-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-08

6248-20-0, 2,4-Dihydroxy-3-methylbenzaldehydeRelated Search:

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  • 2,4-dihydroxy-3-methylbenzaldehyde
  • 3-methyl-2,4-dihydroxybenzaldehyde
  • 4-Formyl-2-methylresorcinol
  • Einecs 228-369-5
  • 2,4-Dihydroxy-3-methylbenzaldehyd
  • 2,4-Dihydroxy-3-meth
  • Benzaldehyde, 2,4-dihydroxy-3-methyl-
  • 4-Hydroxy-3-methylsalicylaldehyde
  • 2-[[(E)-3-(4-methoxyphenyl)-1-oxoprop-2-enyl]amino]benzoic acid methyl ester
  • 4-Dihydroxy-3-methylbenzaldehyde
  • 2,4-Dihydroxy-3-methylbenzaldehyde in Acetonitrile
  • 6248-20-0
  • 6284-20-0