Ceramides
- Product Name
- Ceramides
- CAS No.
- 100403-19-8
- Chemical Name
- Ceramides
- Synonyms
- Ceramides NP;CeramideNP;Aqua Ceramide;Ceramide 3B;Ceramide W.S;Ceramide Powder;Einecs 309-560-3;Ceramides Mixture;CAPROYL SPHINGOSINE;Ceramdie
- CBNumber
- CB4874731
- Molecular Formula
- C24H47NO3
- Formula Weight
- 397.63488
- MOL File
- 100403-19-8.mol
Ceramides Property
- storage temp.
- Store at -20°C
- solubility
- Methanol: 25 mg/mL
- form
- A crystalline solid
- color
- Off-white to light yellow
- LogP
- 13.577 (est)
- CAS DataBase Reference
- 100403-19-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 22853
- Product name
- Ceramides Mixture
- Packaging
- 25mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- CS-0062889
- Product name
- CeramidesMixture
- Purity
- ≥98.0%
- Packaging
- 25mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CS-0062889
- Product name
- CeramidesMixture
- Purity
- ≥98.0%
- Packaging
- 50mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- CS-0062889
- Product name
- CeramidesMixture
- Purity
- ≥98.0%
- Packaging
- 100mg
- Price
- $495
- Updated
- 2021/12/16
Ceramides Chemical Properties,Usage,Production
Description
The ceramides mixture consists of hydroxy and non-hydroxy fatty acid-containing ceramides. Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway, which requires the coordinated action of serine palmitoyl transferase and ceramide synthase. They have been shown to mediate antiproliferative responses such as apoptosis, growth arrest, differentiation, and senescence.
Uses
Ceramides are widely used in cosmetics, including shampoos, deodorants and make-up.
Uses
ceramides is a family of naturally occurring lipids that act primarily in the skin’s uppermost layer, forming a protective barrier and reducing natural transepidermal water loss. Ceramides repair the stratum corneum layer in cases of dry skin, improve skin hydration, and increase the feeling of softness. They are beneficial for stressed, sensitive, scaly, rough, dry, aged, and sun-damaged skin. Ceramides play an essential role in the structure of superficial epidermal layers and form an integral part of the intercellular membrane network. They help generate and sustain the skin’s barrier function. This is extremely important: if the stratum corneum’s hydration is maintained, then it functions more normally in terms of flexibility and desquamation, its integrity is upheld, and the skin is less susceptible to irritation. Ceramide production decreases with age, accentuating any tendency to dry skin. When incorporated into a skin care preparation, the topical application of ceramides could benefit the stratum corneum if the ceramides manage to fill the intercellular spaces and if they are hydrolyzed by the correct extracellular enzymes on the skin. Such application also can stimulate ceramide production in the skin, thereby increasing the skin’s natural lipid content and reinforcing the skin’s protective barrier, measured through transepidermal water loss. Topically applied ceramides have been shown to capture and bind water, necessary for the skin to remain supple, smooth, and hydrated. natural ceramides are obtained from animals and plants. While ceramides can be synthetically manufactured, it is hard to obtain an identical equivalent to those found in nature, making them expensive raw materials.
Mechanism of action
Ceramides, fatty acid and cholesterol constitute the extracellular lipid matrix of epidermal barrier in an approximately equimolar ratio and are assembled in a dense orthorhombic lateral packing within SC interstices. Among them, ceramides are central to the permeability barrier structure and function. Epidermal ceramides account for approximately 50 % of total epidermal lipid by weight. In addition, ceramides also act as an active second messenger, regulate keratinocyte proliferation and differentiation, enhance proinflammatory cytokines production, and modulate immune responses. Aberrant metabolism and function of ceramides is involved in the pathogenesis of several inflammatory skin diseases, including psoriasis, atopic dermatitis (AD) and ichthyosis[1-2].
References
[1] Li, Qingyang , et al. "The Role of Ceramides in Skin Homeostasis and Inflammatory Skin Diseases." Journal of Dermatological Science 97.1(2019).
[2] Koenig, David W., and B. Minerath. "Ceramidase control: An approach to improving skin health."Journal of cosmetic science 59.4(2008):354-355.
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View Lastest Price from Ceramides manufacturers
- Product
- Oil soluble ceramide NP transparent oil 100403-19-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 98% HPLC
- Supply Ability
- 20000kgs
- Release date
- 2023-12-17
- Product
- Ceramide NP2 100403-19-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 98% HPLC
- Supply Ability
- 20000kgs
- Release date
- 2023-12-17
- Product
- NP water-soluble dispersion particles 100403-19-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 98% HPLC
- Supply Ability
- 20000kgs
- Release date
- 2023-12-18