carfenazine
- Product Name
- carfenazine
- CAS No.
- 2622-30-2
- Chemical Name
- carfenazine
- Synonyms
- carfenazine;Carfenazina;Carfenazinum;Carphenazine;Unii-cly16Y8Z7e;Einecs 220-072-9;Carfenazinum [inn-latin];Carfenazina [inn-spanish];1-(10-(3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl)phenothiazin-2-yl)-1-propanone;1-Propanone, 1-[10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]phenoth iazin-2-yl]-
- CBNumber
- CB4899176
- Molecular Formula
- C24H31N3O2S
- Formula Weight
- 425.59
- MOL File
- 2622-30-2.mol
carfenazine Property
- Boiling point:
- 616.9±55.0 °C(Predicted)
- Density
- 1.187±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- form
- Gel
- pka
- 14.96±0.10(Predicted)
- color
- Yellow to Orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H317May cause an allergic skin reaction
H361Suspected of damaging fertility or the unborn child
H370Causes damage to organs
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313IF exposed or concerned: Get medical advice/attention.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C184305
- Product name
- Carphenazine
- Packaging
- 10mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- API0009417
- Product name
- CARPHENAZINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.29
- Updated
- 2021/12/16
- Product number
- 91212
- Product name
- Carphenazine
- Packaging
- 10mg
- Price
- $525
- Updated
- 2021/12/16
- Product number
- 91212
- Product name
- Carphenazine
- Packaging
- 25mg
- Price
- $650
- Updated
- 2021/12/16
carfenazine Chemical Properties,Usage,Production
Originator
Proketazine,Wyeth,US,1962
Uses
Carphenazine is used as an antipsychotic.
Manufacturing Process
As described in US Patent 3,023,146, in a round-bottomed flask were placed
35 g of 2-propionyl phenothiazine (0.14 mol) 7 g of 50% sodium hydride in
mineral oil (0.14 mol), and 240 cc of dimethyl formamide dried over sodium
hydride. The resultant solution was stirred at room temperature for 2 hours,
and then 88 g (0.56 mol) of trimethylene chlorobromide was added at once.
The mixture was stirred for 2 hours, heated at 60 to 70°C for 1 hour and
poured into 2 liters of H2O. The resulting suspension was extracted with ether,
the ether layer separated and the ether removed under vacuum. A gummy
mass remained which was dissolved in decalin and the solution was partly
distilled to remove excess chlorobromide. After removal of most of the decalin
under vacuum, the residue was treated with a large excess of N-(β-
hydroxyethyl)-piperazine and heated on a steam bath for 2 hours. This
material was extracted with dilute aqueous HCl, this acid layer neutralized
with aqueous base and the resulting oil extracted into ether. The ether layer
was washed with water until the washings were neutral and dried over
anhydrous potassium carbonate. On treatment with maleic acid in ether a
yellow solid separated which was recrystallized from isopropanol. This yellow
solid had MP 175° to 177°C.
brand name
Proketazine (Wyeth).
Therapeutic Function
Tranquilizer
carfenazine Preparation Products And Raw materials
Raw materials
Preparation Products
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