ChemicalBook > CAS DataBase List > 4,4'-Bis(2-bromoacetyl)biphenyl

4,4'-Bis(2-bromoacetyl)biphenyl

Product Name
4,4'-Bis(2-bromoacetyl)biphenyl
CAS No.
4072-67-7
Chemical Name
4,4'-Bis(2-bromoacetyl)biphenyl
Synonyms
Einecs 223-785-3;Daclatasvir Intermediate 1;-biphenyl]-4-yl]ethan-1-one;Daclatasvir Intermediates 2;4,4'-bis(bromoacetyl)biphenyl;4,4'-Bis(2-bromoacetyl)biphenyl;4,4'-Bis(2-bromoacetyl)biphenyl(BABP);1,1'-(biphenyl-4,4'-diyl)bis(2-bromoethanone);1,1'-(1,1'-Biphenyl-4,4'-diyl)bis(2-bromoethanone);Ethanone, 1,1'-(1,1'-biphenyl)-4,4'-diylbis(2-bromo-
CBNumber
CB4912273
Molecular Formula
C16H12Br2O2
Formula Weight
396.07
MOL File
4072-67-7.mol
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4,4'-Bis(2-bromoacetyl)biphenyl Property

Melting point:
226-227 °C(Solv: benzene (71-43-2))
Boiling point:
464.8±30.0 °C(Predicted)
Density 
1.622±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
Off-white to light brown Solid
InChI
InChI=1S/C16H12Br2O2/c17-9-15(19)13-5-1-11(2-6-13)12-3-7-14(8-4-12)16(20)10-18/h1-8H,9-10H2
InChIKey
RTSLQVZQORGDQQ-UHFFFAOYSA-N
SMILES
C1(C2=CC=C(C(=O)CBr)C=C2)=CC=C(C(=O)CBr)C=C1
EPA Substance Registry System
Ethanone, 1,1'-[1,1'-biphenyl]-4,4'-diylbis[2-bromo- (4072-67-7)
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Safety

HS Code 
29147000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

AK Scientific
Product number
Y3242
Product name
4,4'-Bis(2-bromoacetyl)biphenyl
Packaging
5g
Price
$36
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0121190
Product name
4,4'-BIS-(2-BROMOACETYL)BIPHENYL
Purity
95.00%
Packaging
5G
Price
$772.58
Updated
2021/12/16
Ambeed
Product number
A795716
Product name
1,1'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-bromoethanone)
Purity
95%
Packaging
1g
Price
$5
Updated
2021/12/16
Ambeed
Product number
A795716
Product name
1,1'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-bromoethanone)
Purity
95%
Packaging
5g
Price
$7
Updated
2021/12/16
Arctom
Product number
AS010044
Product name
1,1'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-bromoethanone)
Purity
95%
Packaging
1g
Price
$11
Updated
2021/12/16
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4,4'-Bis(2-bromoacetyl)biphenyl Chemical Properties,Usage,Production

Uses

4,4'-Bis(2-bromoacetyl)biphenyl is an intermediate in laboratory research and development.

Synthesis

92-52-4

598-21-0

4072-67-7

To a reaction flask was added 138.8 g (1.04 mol, 2.9 eq.) of aluminum trichloride. 700 ml of dichloromethane was added and the system was cooled to 0-10 °C and stirred. 174.6 g (0.87 mol, 2.4 eq.) of bromoacetyl bromide was slowly added dropwise, controlling the temperature to be maintained at 0 to 10 °C during the dropwise addition. After the dropwise addition, stirring of the reaction mixture was continued for 10 to 30 minutes. Subsequently, 150 ml of dichloromethane solution containing 55.8 g (0.36 mol, 1.0 equiv) of biphenyl was slowly added. After the addition was completed, the reaction mixture was gradually warmed to room temperature with continuous stirring. Next, 200 ml of n-heptane was added to the system, the temperature was raised to reflux, and the reaction was maintained at this temperature for 4 to 5 hours until the alkaline reaction was complete and a large amount of product precipitated. The reaction mixture was continued to be stirred at room temperature for 3 to 5 hours, followed by diafiltration to give the crude product 4,4'-bis(2-bromoacetyl)biphenyl (I). The crude product I was suspended in 500 ml of water and stirred for 1 to 2 hours at room temperature and diafiltrated to give 4,4'-bis(2-bromoacetyl)biphenyl crude oil (II). The crude product II was pulped in 300 ml of dichloromethane, stirred for 1 to 2 hours at room temperature and filtered to give purified 4,4'-bis(2-bromoacetyl)biphenyl. Finally, the product was dried under vacuum at 70 °C to give 121.3 g solid with 99.4% purity and 84.9% yield.

References

[1] Patent: CN108727171, 2018, A. Location in patent: Paragraph 0049-0057
[2] Journal of Medicinal Chemistry, 1983, vol. 26, # 1, p. 104 - 107
[3] Journal of the American Pharmaceutical Association (1912-1977), 1954, vol. 43, p. 79,80
[4] Bulletin de la Societe Chimique de France, 1958, p. 1156,1158
[5] Chemical and Pharmaceutical Bulletin, 1971, vol. 19, p. 2262 - 2270

4,4'-Bis(2-bromoacetyl)biphenyl Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-Bis(2-bromoacetyl)biphenyl Suppliers

China 209 China Hong Kong 1 India 7 South Korea 1 United Kingdom 1 United States 5 Global 224
ChemFuture PharmaTech (Jiangsu) Ltd
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Energy Chemical
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SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.
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View Lastest Price from 4,4'-Bis(2-bromoacetyl)biphenyl manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4,4'-Bis(2-bromoacetyl)biphenyl 4072-67-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-28
Nanjing Fred Technology Co., Ltd
Product
4,4'-Bis(2-bromoacetyl)biphenyl 4072-67-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2024-01-05
Shaanxi Dideu Medichem Co. Ltd
Product
4,4'-Bis(2-bromoacetyl)biphenyl 4072-67-7
Price
US $30.00-20.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-07-30

4072-67-7, 4,4'-Bis(2-bromoacetyl)biphenylRelated Search:

Acetylacetone PHENYL VALERATE FIREMASTER BP-6 N-ACETYL-L-TYROSINE ETHYL ESTER Decabromodiphenyl oxide 2-Bromobiphenyl Acetylferrocene L-PICEIN Biphenyl PHENYL RESIN Phenylacetic acid 4'-Methylbiphenyl-4-carbaldehyde 4,4'-Diacetylbiphenyl 4,4'-Dimethylbiphenyl 2-Bromoacetophenone 2-Bromo-4'-methylacetophenone (2-Bromoethyl)benzene 2-BROMO-4'-PHENYLACETOPHENONE

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  • Einecs 223-785-3
  • Ethanone, 1,1'-(1,1'-biphenyl)-4,4'-diylbis(2-bromo-
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  • 2-Bromo-1-[4-[4-(2-bromoacetyl)phenyl]phenyl]ethanone
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  • Daclatasvir Intermediates 2
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  • Daclatasvir Intermediate 1
  • -biphenyl]-4-yl]ethan-1-one
  • 4,4-Bis-2-bromoacetyl-biphenylQ: What is 4,4-Bis-2-bromoacetyl-biphenyl Q: What is the CAS Number of 4,4-Bis-2-bromoacetyl-biphenyl Q: What is the storage condition of 4,4-Bis-2-bromoacetyl-biphenyl Q: What are the applications of 4,4-Bis-2-bromoacetyl-biphenyl
  • 1,1'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-bromoethane-1-one
  • 4,4'-Bis(2-bromoacetyl)biphenyl(BABP)
  • 1,1'-([1,1'-biphenyl]-4,4'-diyl)bis(2-bromoethan-1-one)
  • 1,1'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-bromoethanone)
  • 4,4'-bis(bromoacetyl)biphenyl
  • 4072-67-7