cGAMP disodium

Product Name: cGAMP disodium
CAS No.: 2407516-83-8
Chemical Name: cGAMP disodium
Synonyms: cGAMP disodium;3',3'-cGAMP disodium;3',3'-cGAMP disodium);cGAMP disodium (Cyclic GMP-AMP disodium
CBNumber: CB49272783
Molecular Formula: C20H25N10NaO13P2
Formula Weight: 698.41
MOL File: 2407516-83-8.mol

More

Less

cGAMP disodium Property

storage temp.: Store at -20°C
solubility: Water: 10 mM
form: Solid
color: White to off-white
Water Solubility: Soluble to 10 mM in water

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

cGAMP disodium Chemical Properties,Usage,Production

Uses

cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].

Biological Activity

cGAMP disodium (Cyclic GMP-AMP disodium) is the third cyclic dinucleotide (CDN) to be discovered in bacteria. cGAMP disodium is an effective adjuvant for sublingual vaccination capable of promoting broad immunity including serum anti-PA neutralizing and anti-PA SIgA responses in airway secretions[1][2].

in vivo

cGAMP (5 μg; nostril mucosal adjuvant) disodium promotes the antigen-specific cytokine production by spleen cells of immunized mice^[2].

Animal Model:	Female C57BL/6 (H-2b) mice 6-8 weeks old^[2]
Dosage:	5 μg
Administration:	Nostril mucosal adjuvant
Result:	Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.

IC 50

Human Endogenous Metabolite

storage

Store at -20°C

References

[1] Wright TA, et al. Second messengers and divergent HD - GYP phosphodiesterases regulate 3’,3’ - cGAMP signaling. Mol Microbiol. 2020;113(1):222 - 236.
[2] BRYAN W DAVIES. Coordinated regulation of accessory genetic elements produces cyclic di - nucleotides for V. cholerae virulence.[J]. Cell, 2012, 149 2: 358 - 370. DOI: 10.1016/j.cell.2012.01.053
[3] XU ZHANG. Cyclic GMP - AMP containing mixed phosphodiester linkages is an endogenous high - affinity ligand for STING.[J]. Molecular Cell, 2013, 51 2: 226 - 235. DOI: 10.1016/j.molcel.2013.05.022

cGAMP disodium Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

cGAMP disodium Suppliers

China 24 United States 3 Global 27

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2989
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
Advantage: 68

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2742
Advantage: 58

Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
ProdList: 7982
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

Hangzhou Huiyi Biotechnology Co., LTD

Tel: 0571-89918262 13357170655
Email: chenlingwei@hizyme.com
Country: China
ProdList: 208
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29491
Advantage: 58

Shanghai Kaisen Biotechnology Co., Ltd

Tel: 17558870519
Email: 3549952815@qq.com
Country: China
ProdList: 2312
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 028-81700200 13308200041
Email: 2851167782@qq.com
Country: China
ProdList: 11146
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18651614124
Email: 2881516338@qq.com
Country: China
ProdList: 10000
Advantage: 58

Yeasen Biotechnology (Shanghai) Co Ltd

Tel: 400-6111-883 13121892008
Email: marketing@yeasen.com
Country: China
ProdList: 6173
Advantage: 58

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8467
Advantage: 58

Nantong HI-FUTURE Biology Co., Ltd.

Tel: +undefined18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 3135
Advantage: 58

Guangzhou Suyan Biotechnology Co., Ltd

Tel: 18818417021
Country: CHINA
ProdList: 127
Advantage: 58

Guangzhou Squirrel Biotechnology Co., Ltd.

Tel: 17765276361
Country: CHINA
ProdList: 109
Advantage: 58

Nanjing Zeta Instrument Equipment Co., Ltd.

Tel: 13382061751
Country: CHINA
ProdList: 121
Advantage: 58

Invivochem

Tel: --
Fax: --
Email: 191781430@QQ.com
Country: China
ProdList: 12
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

2407516-83-8, cGAMP disodiumRelated Search:

INDEX NAME NOT YET ASSIGNED Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-2'-O-methyladenylyl-(3'→5')-, inner salt (9CI) c-GpAp 2'3'-cGAMP 2'2'-cGAMP

cGAMP disodium

3',3'-cGAMP disodium)

cGAMP disodium (Cyclic GMP-AMP disodium

3',3'-cGAMP disodium

2407516-83-8