ChemicalBook > CAS DataBase List > 3,4-dihydro-2H-1,4-benzoxazin-6-ol

3,4-dihydro-2H-1,4-benzoxazin-6-ol

Product Name
3,4-dihydro-2H-1,4-benzoxazin-6-ol
CAS No.
26021-57-8
Chemical Name
3,4-dihydro-2H-1,4-benzoxazin-6-ol
Synonyms
3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-OL;3,4-Dihyd2H-benzo[b][1,4]oxazin-6-ol;3,4-Dihydro-2H-benzo[1,4]oxazin-6-ol;2H-1,4-Benzoxazin-6-ol, 3,4-dihydro-;3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZIN-6-OL
CBNumber
CB4940667
Molecular Formula
C8H9NO2
Formula Weight
151.16
MOL File
26021-57-8.mol
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3,4-dihydro-2H-1,4-benzoxazin-6-ol Property

Boiling point:
334.7±42.0 °C(Predicted)
Density 
1.241±0.06 g/cm3(Predicted)
vapor pressure 
0.002Pa at 20℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly, Heated, Sonicated), DMSO (Sparingly), Methanol (Slightly)
form 
Solid
pka
10.85±0.20(Predicted)
color 
Black
Water Solubility 
19g/L at 20℃
Stability:
Hygroscopic
InChI
InChI=1S/C8H9NO2/c10-6-1-2-8-7(5-6)9-3-4-11-8/h1-2,5,9-10H,3-4H2
InChIKey
HWWIVWKTKZAORO-UHFFFAOYSA-N
SMILES
O1C2=CC=C(O)C=C2NCC1
LogP
0.219 at 23℃
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D679870
Product name
3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol
Packaging
100mg
Price
$125
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD158110
Product name
3,4-Dihydro-2H-1,4-benzoxazin-6-ol
Packaging
50mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD158110
Product name
3,4-Dihydro-2H-1,4-benzoxazin-6-ol
Packaging
100mg
Price
$120
Updated
2021/12/16
Apolloscientific
Product number
OR346495
Product name
3,4-Dihydro-2H-benzo[1,4]oxazin-6-ol
Purity
95+%
Packaging
1g
Price
$201
Updated
2021/12/16
AK Scientific
Product number
2204AB
Product name
3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol
Packaging
250mg
Price
$203
Updated
2021/12/16
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3,4-dihydro-2H-1,4-benzoxazin-6-ol Chemical Properties,Usage,Production

Flammability and Explosibility

Not classified

Synthesis

53412-38-7

26021-57-8

General procedure for the synthesis of 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-ol from 6-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one: 6-Hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one (0.39 g, 2.35 mmol) was dissolved in tetrahydrofuran (THF) and at 0 °C 1 M borane-THF solution (7.05 mL, 7.05 mmol) was slowly added dropwise for a controlled time of 5 min. After the dropwise addition, the reaction mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, the excess borane was quenched by careful addition of methanol. Subsequently, the solvent was removed by distillation under reduced pressure and the crude product was extracted with ethyl acetate (EtOAc) to afford pure 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-ol as an oil in quantitative yield (0.34 g). The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, DMSO-d6): δ 8.48 (s, 1H), 6.37 (d, 1H, J = 8.47 Hz), 5.96 (d, 1H, J = 2.75 Hz), 5.82 (dd, 1H, J = 8.44, 2.76 Hz), 3.97 (t, 2H, J = 4.38 Hz), 3.18 ( t, 2H, J = 4.31 Hz). Nuclear magnetic resonance carbon spectrum (13C NMR, DMSO-d6): δ 152.2, 136.6, 135.8, 116.7, 103.8, 102.0, 65.0, 47.2. electrospray high-resolution mass spectrometry (ES-HRMS) measured [M + H]+ as 152.0711, which is in accordance with the theoretically calculated value (C8H10NO2).

References

[1] Patent: WO2009/36351, 2009, A2. Location in patent: Page/Page column 21; 22/24

3,4-dihydro-2H-1,4-benzoxazin-6-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,4-dihydro-2H-1,4-benzoxazin-6-ol manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3,4-dihydro-2H-1,4-benzoxazin-6-ol 26021-57-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10000KGS
Release date
2025-02-18

26021-57-8, 3,4-dihydro-2H-1,4-benzoxazin-6-olRelated Search:

2H-1,4-Benzoxazin-8-amine,3,4-dihydro-(9CI) Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) 3,4-Dihydro-1,8-naphthyridin-2(1H)-one 3,4-DIHYDRO-2H-PYRROLO[1,2-A]PYRAZIN-1-ONE 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-AMINE 2H-1,4-Benzoxazin-8-ol, 3,4-dihydro- (9CI) Pyrimido[4,5-d]pyrimidin-4-ol, 3,4-dihydro- (9CI) 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE-8-CARBONITRILE HYDROCHLORIDE 3,4-dihydro-2H-1,4-benzoxazin-6-ol Benzomorpholine 6-METHOXY-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE 3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-6-OLHYDROBROMIDE 6-METHOXY-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE ETHYL 6-METHOXY-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-2-CARBOXYLATE 6-METHOXY-2-METHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE 6-Trifluoromethoxy-3,4-dihydro-2Hbenzo[1,4]oxazine-8-carboxylic acid methyl ester 3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-6-OL HYDROCHLORIDE 8-METHYL-3,4-DIHYDRO-2H-1,5-DIOXA-4-AZA-ANTHRACEN-6-ONE

  • 3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZIN-6-OL
  • 2H-1,4-Benzoxazin-6-ol, 3,4-dihydro-
  • 3,4-Dihydro-2H-benzo[1,4]oxazin-6-ol
  • 3,4-Dihyd2H-benzo[b][1,4]oxazin-6-ol
  • 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-OL
  • 26021-57-8