3,4-dihydro-2H-1,4-benzoxazin-6-ol

Product Name: 3,4-dihydro-2H-1,4-benzoxazin-6-ol
CAS No.: 26021-57-8
Chemical Name: 3,4-dihydro-2H-1,4-benzoxazin-6-ol
Synonyms: 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-OL;3,4-Dihyd2H-benzo[b][1,4]oxazin-6-ol;3,4-Dihydro-2H-benzo[1,4]oxazin-6-ol;2H-1,4-Benzoxazin-6-ol, 3,4-dihydro-;3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZIN-6-OL
CBNumber: CB4940667
Molecular Formula: C8H9NO2
Formula Weight: 151.16
MOL File: 26021-57-8.mol

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3,4-dihydro-2H-1,4-benzoxazin-6-ol Property

Boiling point:: 334.7±42.0 °C(Predicted)
Density: 1.241±0.06 g/cm3(Predicted)
vapor pressure: 0.002Pa at 20℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly, Heated, Sonicated), DMSO (Sparingly), Methanol (Slightly)
form: Solid
pka: 10.85±0.20(Predicted)
color: Black
Water Solubility: 19g/L at 20℃
Stability:: Hygroscopic
InChI: InChI=1S/C8H9NO2/c10-6-1-2-8-7(5-6)9-3-4-11-8/h1-2,5,9-10H,3-4H2
InChIKey: HWWIVWKTKZAORO-UHFFFAOYSA-N
SMILES: O1C2=CC=C(O)C=C2NCC1
LogP: 0.219 at 23℃

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D679870
Product name: 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol
Packaging: 100mg
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD158110
Product name: 3,4-Dihydro-2H-1,4-benzoxazin-6-ol
Packaging: 50mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD158110
Product name: 3,4-Dihydro-2H-1,4-benzoxazin-6-ol
Packaging: 100mg
Price: $120
Updated: 2021/12/16

Apolloscientific

Product number: OR346495
Product name: 3,4-Dihydro-2H-benzo[1,4]oxazin-6-ol
Purity: 95+%
Packaging: 1g
Price: $201
Updated: 2021/12/16

AK Scientific

Product number: 2204AB
Product name: 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol
Packaging: 250mg
Price: $203
Updated: 2021/12/16

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3,4-dihydro-2H-1,4-benzoxazin-6-ol Chemical Properties,Usage,Production

Flammability and Explosibility

Not classified

Synthesis

53412-38-7

26021-57-8

General procedure for the synthesis of 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-ol from 6-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one: 6-Hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one (0.39 g, 2.35 mmol) was dissolved in tetrahydrofuran (THF) and at 0 °C 1 M borane-THF solution (7.05 mL, 7.05 mmol) was slowly added dropwise for a controlled time of 5 min. After the dropwise addition, the reaction mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, the excess borane was quenched by careful addition of methanol. Subsequently, the solvent was removed by distillation under reduced pressure and the crude product was extracted with ethyl acetate (EtOAc) to afford pure 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-ol as an oil in quantitative yield (0.34 g). The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, DMSO-d6): δ 8.48 (s, 1H), 6.37 (d, 1H, J = 8.47 Hz), 5.96 (d, 1H, J = 2.75 Hz), 5.82 (dd, 1H, J = 8.44, 2.76 Hz), 3.97 (t, 2H, J = 4.38 Hz), 3.18 ( t, 2H, J = 4.31 Hz). Nuclear magnetic resonance carbon spectrum (13C NMR, DMSO-d6): δ 152.2, 136.6, 135.8, 116.7, 103.8, 102.0, 65.0, 47.2. electrospray high-resolution mass spectrometry (ES-HRMS) measured [M + H]+ as 152.0711, which is in accordance with the theoretically calculated value (C8H10NO2).

References

[1] Patent: WO2009/36351, 2009, A2. Location in patent: Page/Page column 21; 22/24

3,4-dihydro-2H-1,4-benzoxazin-6-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-dihydro-2H-1,4-benzoxazin-6-ol Suppliers

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View Lastest Price from 3,4-dihydro-2H-1,4-benzoxazin-6-ol manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3,4-dihydro-2H-1,4-benzoxazin-6-ol 26021-57-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10000KGS
Release date: 2025-02-18

26021-57-8, 3,4-dihydro-2H-1,4-benzoxazin-6-olRelated Search:

2H-1,4-Benzoxazin-8-amine,3,4-dihydro-(9CI) Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) 3,4-Dihydro-1,8-naphthyridin-2(1H)-one 3,4-DIHYDRO-2H-PYRROLO[1,2-A]PYRAZIN-1-ONE 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-AMINE 2H-1,4-Benzoxazin-8-ol, 3,4-dihydro- (9CI) Pyrimido[4,5-d]pyrimidin-4-ol, 3,4-dihydro- (9CI) 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE-8-CARBONITRILE HYDROCHLORIDE 3,4-dihydro-2H-1,4-benzoxazin-6-ol Benzomorpholine 6-METHOXY-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE 3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-6-OLHYDROBROMIDE 6-METHOXY-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE ETHYL 6-METHOXY-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-2-CARBOXYLATE 6-METHOXY-2-METHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE 6-Trifluoromethoxy-3,4-dihydro-2Hbenzo[1,4]oxazine-8-carboxylic acid methyl ester 3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-6-OL HYDROCHLORIDE 8-METHYL-3,4-DIHYDRO-2H-1,5-DIOXA-4-AZA-ANTHRACEN-6-ONE

3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZIN-6-OL

2H-1,4-Benzoxazin-6-ol, 3,4-dihydro-

3,4-Dihydro-2H-benzo[1,4]oxazin-6-ol

3,4-Dihyd2H-benzo[b][1,4]oxazin-6-ol

3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-OL

26021-57-8