Benzomorpholine

Product Name: Benzomorpholine
CAS No.: 5735-53-5
Chemical Name: Benzomorpholine
Synonyms: AKOS BC-1149;BENZOMORPHOLINE;AKOS BBS-00002717;CHEMBRDG-BB 4005008;2,3-dihydro-1,4-benzoxazine;3,4-DIHYDRO-2H-1,4-BENZOXAZINE;3,4-Dihydro-2H-benzo[1,4]oxazine;2H-1,4-Benzoxazine, 3,4-dihydro-;3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE;3,4-Dihydro-2H-1,4-benzoxazine, 97+%
CBNumber: CB3231131
Molecular Formula: C8H9NO
Formula Weight: 135.16
MOL File: 5735-53-5.mol

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Benzomorpholine Property

Boiling point:: 85°C/0.75mm
Density: 1.095±0.06 g/cm3(Predicted)
refractive index: 1.60
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: clear liquid
pka: 4.37±0.20(Predicted)
color: Colorless to Yellow to Orange
Water Solubility: Sparingly soluble in water.(0.26 g/L) (25°C),
InChI: InChI=1S/C8H9NO/c1-2-4-8-7(3-1)9-5-6-10-8/h1-4,9H,5-6H2
InChIKey: YRLORWPBJZEGBX-UHFFFAOYSA-N
SMILES: O1C2=CC=CC=C2NCC1

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5104
Product name: 3,4-Dihydro-2H-1,4-benzoxazine
Packaging: 1G
Price: $68
Updated: 2025/07/31

TRC

Product number: D451430
Product name: 3,4-Dihydro-2h-1,4-benzoxazine
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD76095
Product name: 3,4-Dihydro-2h-1,4-benzoxazine
Packaging: 2g
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD76095
Product name: 3,4-Dihydro-2h-1,4-benzoxazine
Packaging: 1g
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 088008
Product name: 3,4-Dihydro-2H-1,4-benzoxazine
Packaging: 1g
Price: $179
Updated: 2021/12/16

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Benzomorpholine Chemical Properties,Usage,Production

Uses

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Definition

ChEBI: 3,4-Dihydro-2H-1,4-benzoxazine is a benzoxazine.

Synthesis

106-93-4

95-55-6

5735-53-5

To a suspension of 2-aminophenol (1.0 g, 9.2 mmol) and potassium carbonate (6.36 g, 46 mmol) in anhydrous DMF (10 mL) was added 1,2-dibromoethane (2.59 g, 13.8 mmol). The reaction mixture was heated at 125 °C with stirring for 15 hours. After completion of the reaction, it was cooled to room temperature, the mixture was poured into crushed ice and extracted with ethyl acetate (3 × 20 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1:10, v/v) as eluent to afford 3,4-dihydro-2H-benzo[b][1,4]oxazine as a red oil (0.81 g, 65% yield). The product was analyzed by LC-MS (ES-API): retention time 7.51 min; calculated value C8H9NO [M+H]+ 136.1, measured value 136.1.

References

[1] Tetrahedron Letters, 2006, vol. 47, # 44, p. 7823 - 7826
[2] Patent: WO2011/47432, 2011, A1. Location in patent: Page/Page column 88
[3] Heterocyclic Communications, 2012, vol. 18, # 3, p. 143 - 146
[4] Patent: WO2010/51374, 2010, A1. Location in patent: Page/Page column 132
[5] Patent: EP2172453, 2010, A1. Location in patent: Page/Page column 13

Benzomorpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzomorpholine Suppliers

Americas 1 CHINA 120 Europe 1 France 1 Germany 3 India 4 Japan 1 Ukraine 1 United Kingdom 5 United States 14 Global 151

HuiFeiChem(WuXi) PharmaTech Co.,Ltd

Tel: 0510-0510-83593305
Fax: 0086-510-83593305
Email: sales@huifeichem.com
Country: China
ProdList: 102
Advantage: 62

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Yangzhou Siyu Chemical Co.,Ltd.

Tel: 0514-87325867
Fax: 0086-514-87325867
Email: sales@siyuchem.com
Country: China
ProdList: 370
Advantage: 55

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

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View Lastest Price from Benzomorpholine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3,4-Dihydro-2H-1,4-benzoxazine 5735-53-5
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Henan Aochuang Chemical Co.,Ltd.

Product: Benzomorpholine 5735-53-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Shanghai Rlavie Technology Co ltd

Product: Benzomorpholine 5735-53-5
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2022-01-03

5735-53-5, BenzomorpholineRelated Search:

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7-Oxa-10-azabicyclo[4.4.0]deca-1,3,5-triene

AKOS BC-1149

AKOS BBS-00002717

2,3-dihydro-1,4-benzoxazine

Benzomorpholine(3,4-Dihydro-2H-1,4-benzoxazine)

3,4-DIHYDRO-2H-1,4-BENZOXAZINE

BENZOMORPHOLINE

CHEMBRDG-BB 4005008

3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE

3,4-Dihydro-2H-1,4-benzoxazine hydrochloride

3,4-Dihydro-2H-1,4-benzoxazine, 97+%

3,4-dihydro-2H-1,4-benzoxazine(SALTDATA: FREE)

3,4-Dihydro-2H-benzo[1,4]oxazine

2H-1,4-Benzoxazine, 3,4-dihydro-

5735-53-5

pharmacetical

Heterocycles series