Benzomorpholine
- Product Name
- Benzomorpholine
- CAS No.
- 5735-53-5
- Chemical Name
- Benzomorpholine
- Synonyms
- AKOS BC-1149;BENZOMORPHOLINE;AKOS BBS-00002717;CHEMBRDG-BB 4005008;2,3-dihydro-1,4-benzoxazine;3,4-DIHYDRO-2H-1,4-BENZOXAZINE;3,4-Dihydro-2H-benzo[1,4]oxazine;2H-1,4-Benzoxazine, 3,4-dihydro-;3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE;3,4-Dihydro-2H-1,4-benzoxazine, 97+%
- CBNumber
- CB3231131
- Molecular Formula
- C8H9NO
- Formula Weight
- 135.16
- MOL File
- 5735-53-5.mol
Benzomorpholine Property
- Boiling point:
- 85°C/0.75mm
- Density
- 1.095±0.06 g/cm3(Predicted)
- refractive index
- 1.60
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- clear liquid
- pka
- 4.37±0.20(Predicted)
- color
- Colorless to Yellow to Orange
- Water Solubility
- Sparingly soluble in water.(0.26 g/L) (25°C),
- InChI
- InChI=1S/C8H9NO/c1-2-4-8-7(3-1)9-5-6-10-8/h1-4,9H,5-6H2
- InChIKey
- YRLORWPBJZEGBX-UHFFFAOYSA-N
- SMILES
- O1C2=CC=CC=C2NCC1
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D5104
- Product name
- 3,4-Dihydro-2H-1,4-benzoxazine
- Packaging
- 1G
- Price
- $68
- Updated
- 2025/07/31
- Product number
- D451430
- Product name
- 3,4-Dihydro-2h-1,4-benzoxazine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FD76095
- Product name
- 3,4-Dihydro-2h-1,4-benzoxazine
- Packaging
- 2g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD76095
- Product name
- 3,4-Dihydro-2h-1,4-benzoxazine
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 088008
- Product name
- 3,4-Dihydro-2H-1,4-benzoxazine
- Packaging
- 1g
- Price
- $179
- Updated
- 2021/12/16
Benzomorpholine Chemical Properties,Usage,Production
Uses
It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.
Definition
ChEBI: 3,4-Dihydro-2H-1,4-benzoxazine is a benzoxazine.
Synthesis
106-93-4
95-55-6
5735-53-5
To a suspension of 2-aminophenol (1.0 g, 9.2 mmol) and potassium carbonate (6.36 g, 46 mmol) in anhydrous DMF (10 mL) was added 1,2-dibromoethane (2.59 g, 13.8 mmol). The reaction mixture was heated at 125 °C with stirring for 15 hours. After completion of the reaction, it was cooled to room temperature, the mixture was poured into crushed ice and extracted with ethyl acetate (3 × 20 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1:10, v/v) as eluent to afford 3,4-dihydro-2H-benzo[b][1,4]oxazine as a red oil (0.81 g, 65% yield). The product was analyzed by LC-MS (ES-API): retention time 7.51 min; calculated value C8H9NO [M+H]+ 136.1, measured value 136.1.
References
[1] Tetrahedron Letters, 2006, vol. 47, # 44, p. 7823 - 7826
[2] Patent: WO2011/47432, 2011, A1. Location in patent: Page/Page column 88
[3] Heterocyclic Communications, 2012, vol. 18, # 3, p. 143 - 146
[4] Patent: WO2010/51374, 2010, A1. Location in patent: Page/Page column 132
[5] Patent: EP2172453, 2010, A1. Location in patent: Page/Page column 13
Benzomorpholine Preparation Products And Raw materials
Raw materials
Preparation Products
Benzomorpholine Suppliers
- Tel
- --
- Fax
- --
- sales@aaron-chemistry.de
- Country
- Germany
- ProdList
- 579
- Advantage
- 60
- Tel
- --
- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
- Tel
- --
- Fax
- --
- akos@akosgmbh.de
- Country
- Germany
- ProdList
- 6717
- Advantage
- 72
View Lastest Price from Benzomorpholine manufacturers
- Product
- 3,4-Dihydro-2H-1,4-benzoxazine 5735-53-5
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- Benzomorpholine 5735-53-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- Benzomorpholine 5735-53-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-01-03