2-(Methylamino)pyridine-3-methanol

Product Name: 2-(Methylamino)pyridine-3-methanol
CAS No.: 32399-12-5
Chemical Name: 2-(Methylamino)pyridine-3-methanol
Synonyms: 2-(N-Methylamino);-3-hydroxymethylpyridine;Isavuconazole internediate;2-(Methylamino)pyridine-3-methanol;2-(MethylaMino)-3-PyridineMethanol;[2-(Methylamino)-3-pyridyl]methanol;3-Pyridinemethanol, 2-(methylamino)-;[2-(methylamino)-3-pyridinyl]methanol;[2-(Methylamino)pyridin-3-yl]methanol;3-HYDROXYMETHYL 2-METHYLAMINO PYRIDINE
CBNumber: CB4966256
Molecular Formula: C7H10N2O
Formula Weight: 138.17
MOL File: 32399-12-5.mol

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2-(Methylamino)pyridine-3-methanol Property

Boiling point:: 312.2±32.0 °C(Predicted)
Density: 1.191±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 13.63±0.10(Predicted)
InChI: InChI=1S/C7H10N2O/c1-8-7-6(5-10)3-2-4-9-7/h2-4,10H,5H2,1H3,(H,8,9)
InChIKey: VYPMWCUNCNMNOM-UHFFFAOYSA-N
SMILES: C1(NC)=NC=CC=C1CO

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Safety

Safety Statements: 24/25
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: M331148
Product name: 2-(Methylamino)pyridine-3-methanol
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 074187
Product name: 2-(N-Methylamino)-3-hydroxymethylpyridine
Purity: 95+%
Packaging: 1g
Price: $54
Updated: 2021/12/16

ChemScene

Product number: CS-W023173
Product name: 2-(Methylamino)-3-pyridinemethanol
Purity: 98.67%
Packaging: 10g
Price: $54
Updated: 2021/12/16

AK Scientific

Product number: W5421
Product name: 2-(N-Methylamino)-3-hydroxymethylpyridine
Packaging: 1g
Price: $66
Updated: 2021/12/16

AK Scientific

Product number: W5421
Product name: 2-(N-Methylamino)-3-hydroxymethylpyridine
Packaging: 5g
Price: $90
Updated: 2021/12/16

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2-(Methylamino)pyridine-3-methanol Chemical Properties,Usage,Production

Description

2-(Methylamino)pyridine-3-methanol is an industrial chemical that is used as a solvent and in the production of potassium sulfate. It has a high boiling point, which makes it a good choice for large-scale industrial processes. 2-(Methylamino)pyridine-3-methanol is also an organic solvent, which can be used to dissolve many other molecules.

Uses

2-(Methylamino)pyridine-3-methanol is a raw material for the synthesis of isavuconazolium sulfate (triazole antifungal drug).

Preparation

Method 1: 2-Chloronicotinic acid is used as the starting material, reacted with methylamine hydrochloride, potassium carbonate, and cuprous bromide in DMF solvent at 100°C to prepare 2-methylamino-3-pyridinecarboxylic acid, and then reduced with lithium aluminium hydride to obtain the target product 2-(Methylamino)pyridine-3-methanol.
Method 2: 2-Methylamino-3-pyridinecarboxylic acid tert-butyl ester is reduced to the 2-methylamino-3-pyridinemethanol in an organic solvent and the presence of sodium borohydride/Lewis acid or potassium borohydride/Lewis acid reducing agent. 180 mL of tetrahydrofuran, 11.4 g (0.300 mol) of potassium borohydride, and 20.5 g (0.150 mol) of zinc chloride are added to a 500 mL three-necked flask and stirred at room temperature for 2 hours. Add 25g (0.120mol) of tert-butyl 2-methylamino-3-pyridinecarboxylate and 84mL of toluene. During the addition process, bubbles are released, and the addition rate is controlled. Keep reflux until the addition and reaction are complete. Then cool to room temperature and add 20% sodium hydroxide solution until the solution is clear. Then add ethyl acetate 500mL*3 to extract three times, combine the organic phases, wash twice with saturated brine 250mL*2, dry with anhydrous sodium sulfate, and spin dry to obtain 2-methylamino-3-pyridinemethanol as a white solid. Then, recrystallize from isopropanol/n-hexane to obtain 13.0g of a white solid with a yield of 88.2%.

2-(Methylamino)pyridine-3-methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(Methylamino)pyridine-3-methanol Suppliers

Canada 1 China 226 France 1 India 3 United Kingdom 2 United States 12 Global 245

Chengdu syns Pharmaceutical Co., Ltd.

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Adamas Reagent, Ltd.

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View Lastest Price from 2-(Methylamino)pyridine-3-methanol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-(Methylamino)pyridine-3-methanol 32399-12-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10kg/month
Release date: 2022-12-28

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Isavuconazole Impurity 37 32399-12-5
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-07-10

Henan Aochuang Chemical Co.,Ltd.

Product: 2-(Methylamino)pyridine-3-methanol 32399-12-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

32399-12-5, 2-(Methylamino)pyridine-3-methanolRelated Search:

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32399-12-5

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