ChemicalBook > CAS DataBase List > 2-(Methylamino)pyridine-3-methanol

2-(Methylamino)pyridine-3-methanol

Product Name
2-(Methylamino)pyridine-3-methanol
CAS No.
32399-12-5
Chemical Name
2-(Methylamino)pyridine-3-methanol
Synonyms
2-(N-Methylamino);-3-hydroxymethylpyridine;Isavuconazole internediate;2-(Methylamino)pyridine-3-methanol;2-(MethylaMino)-3-PyridineMethanol;[2-(Methylamino)-3-pyridyl]methanol;3-Pyridinemethanol, 2-(methylamino)-;[2-(methylamino)-3-pyridinyl]methanol;[2-(Methylamino)pyridin-3-yl]methanol;3-HYDROXYMETHYL 2-METHYLAMINO PYRIDINE
CBNumber
CB4966256
Molecular Formula
C7H10N2O
Formula Weight
138.17
MOL File
32399-12-5.mol
More
Less

2-(Methylamino)pyridine-3-methanol Property

Boiling point:
312.2±32.0 °C(Predicted)
Density 
1.191±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
13.63±0.10(Predicted)
InChI
InChI=1S/C7H10N2O/c1-8-7-6(5-10)3-2-4-9-7/h2-4,10H,5H2,1H3,(H,8,9)
InChIKey
VYPMWCUNCNMNOM-UHFFFAOYSA-N
SMILES
C1(NC)=NC=CC=C1CO
More
Less

Safety

Safety Statements 
24/25
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

TRC
Product number
M331148
Product name
2-(Methylamino)pyridine-3-methanol
Packaging
250mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
074187
Product name
2-(N-Methylamino)-3-hydroxymethylpyridine
Purity
95+%
Packaging
1g
Price
$54
Updated
2021/12/16
ChemScene
Product number
CS-W023173
Product name
2-(Methylamino)-3-pyridinemethanol
Purity
98.67%
Packaging
10g
Price
$54
Updated
2021/12/16
AK Scientific
Product number
W5421
Product name
2-(N-Methylamino)-3-hydroxymethylpyridine
Packaging
1g
Price
$66
Updated
2021/12/16
AK Scientific
Product number
W5421
Product name
2-(N-Methylamino)-3-hydroxymethylpyridine
Packaging
5g
Price
$90
Updated
2021/12/16
More
Less

2-(Methylamino)pyridine-3-methanol Chemical Properties,Usage,Production

Description

2-(Methylamino)pyridine-3-methanol is an industrial chemical that is used as a solvent and in the production of potassium sulfate. It has a high boiling point, which makes it a good choice for large-scale industrial processes. 2-(Methylamino)pyridine-3-methanol is also an organic solvent, which can be used to dissolve many other molecules. 

Uses

2-(Methylamino)pyridine-3-methanol is a raw material for the synthesis of isavuconazolium sulfate (triazole antifungal drug).

Preparation

Method 1: 2-Chloronicotinic acid is used as the starting material, reacted with methylamine hydrochloride, potassium carbonate, and cuprous bromide in DMF solvent at 100°C to prepare 2-methylamino-3-pyridinecarboxylic acid, and then reduced with lithium aluminium hydride to obtain the target product 2-(Methylamino)pyridine-3-methanol.
Method 2: 2-Methylamino-3-pyridinecarboxylic acid tert-butyl ester is reduced to the 2-methylamino-3-pyridinemethanol in an organic solvent and the presence of sodium borohydride/Lewis acid or potassium borohydride/Lewis acid reducing agent. 180 mL of tetrahydrofuran, 11.4 g (0.300 mol) of potassium borohydride, and 20.5 g (0.150 mol) of zinc chloride are added to a 500 mL three-necked flask and stirred at room temperature for 2 hours. Add 25g (0.120mol) of tert-butyl 2-methylamino-3-pyridinecarboxylate and 84mL of toluene. During the addition process, bubbles are released, and the addition rate is controlled. Keep reflux until the addition and reaction are complete. Then cool to room temperature and add 20% sodium hydroxide solution until the solution is clear. Then add ethyl acetate 500mL*3 to extract three times, combine the organic phases, wash twice with saturated brine 250mL*2, dry with anhydrous sodium sulfate, and spin dry to obtain 2-methylamino-3-pyridinemethanol as a white solid. Then, recrystallize from isopropanol/n-hexane to obtain 13.0g of a white solid with a yield of 88.2%.

2-(Methylamino)pyridine-3-methanol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-(Methylamino)pyridine-3-methanol Suppliers

Canada 1 China 230 France 1 India 3 United Kingdom 2 United States 12 Global 249
Chengdu syns Pharmaceutical Co., Ltd.
Tel
028-82093588 18980782991
Fax
(+86) 028-89481917
Email
sales@syns.org
Country
China
ProdList
61
Advantage
55
Shanghai Weishukur Medical Technology Co., LTD
Tel
15250615384
Email
316228842@qq.com
Country
China
ProdList
313
Advantage
58
Tai Zhou World Pharm & Chem Co., Ltd
Tel
0576-85301198 13736201658
Email
16029347@qq.com
Country
China
ProdList
104
Advantage
58
Medsyn Biotechnology Co., Ltd
Tel
028-82250492; 15121117545
Fax
QQ 3627337140
Email
viola.liu@medsynbio.cn
Country
China
ProdList
99
Advantage
58
Hunan Tengyu New Materials Co., Ltd.
Tel
1822-9738810 18229738810
Email
3590064534@qq.com
Country
China
ProdList
127
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1390
Advantage
62
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Beijing Lunarsun Pharmaceutical Co.,LTD.
Tel
86-10-64911848-8020.8010
Fax
86-10-64946614
Email
sales@lunarsun.com.cn
Country
China
ProdList
95
Advantage
60
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Jinan Bond Chemical Technology Co., Ltd.
Tel
86-531-88280989
Fax
86-531-88280989
Email
mymail1996@126.com
Country
China
ProdList
256
Advantage
55
Suzhou giant chemical CO., Ltd.
Tel
+86-512-82870298 15295544306 15295544306
Email
giantchem@163.com QQ
Country
China
ProdList
20
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Porse Fine Chemical Co.,LTD
Tel
20-66003216 18666003216
Fax
+86-20-28069063
Email
info@porsefinechemical.com
Country
China
ProdList
2353
Advantage
62
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9346
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
15523000485
Email
xingcanyaoye@sina.com
Country
China
ProdList
1686
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10276
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4767
Advantage
60
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11481
Advantage
59
Shanghai Na Qian Chemical Technology Co. Ltd.
Tel
0373-7129549; 13598610367
Fax
QQ:2468833170
Email
2841375912@qq.com
Country
China
ProdList
2725
Advantage
52
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5806
Advantage
50
Beijing Xinsavi Chemical Technology Co., Ltd.
Tel
010-56218822 13717722232
Fax
010-56218800
Email
xinsavichem@163.com
Country
China
ProdList
3201
Advantage
56
Beijing Holiyang Chemical Co. Ltd.
Tel
13718199399
Fax
QQ : 206661479
Email
holiyangchem@163.com
Country
China
ProdList
3381
Advantage
56
Shanghai YouPeng Chemical Co. Ltd.
Tel
021-69005955 13701776567
Fax
021-69005775
Email
youpengchem@163.com
Country
China
ProdList
4293
Advantage
56
Sichuan Hainuowei Technology Co. Ltd.
Tel
13708085536
Fax
QQ : 121102042
Email
hanovichem@163.com
Country
China
ProdList
3383
Advantage
56
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16684
Advantage
50
Shanghai TongYuan Chemical Co., Ltd.
Tel
021-021-69182866 13701855675
Fax
021-69182022
Email
tongyuanchem@126.com
Country
China
ProdList
4321
Advantage
58
Shanghai Kaisai Chemical Co., Ltd
Tel
021-33516722 13701817765
Fax
021-33516776
Email
kaisaichem@163.com
Country
China
ProdList
4741
Advantage
58
Beijing HuaYangZhicheng Technology Co., Ltd.
Tel
13716033033
Fax
010-56276266
Email
hanchochem@163.com
Country
China
ProdList
2960
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Shanghai LanRun Chemical Co., Ltd.
Tel
021-69515658 ; 69515628 13701998368
Fax
021-69515998
Email
longrunchem@163.com
Country
China
ProdList
3912
Advantage
50
Shanghai Rolead Chemical Technology Co., Ltd.
Tel
021-69992220 13701886816
Fax
021-69992237
Email
roleadchem@163.com
Country
China
ProdList
4750
Advantage
50
Shanghai Kangtuo Chemical Co., Ltd.
Tel
021-69185552 13701777608
Fax
021-69186006
Email
kangtuochem@163.com
Country
China
ProdList
4360
Advantage
55
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9958
Advantage
58
Gansu HaoTian Chemical Technology Co., Ltd.
Tel
0943-6900332 17789447501
Fax
0931-8238232
Email
zhuanxiajiang@haotianpharm.com
Country
China
ProdList
194
Advantage
55
Tongling HengYou Biotechnology Co., Ltd.
Tel
021-50426030 13856289449
Fax
021-50426030
Email
2630597085@qq.com
Country
China
ProdList
1889
Advantage
55
SanoChem (Chengdu) Tech. Co., Ltd.
Tel
28-87999436 02887999436
Fax
QQ:2746983436
Email
sales@sano-chem.com
Country
China
ProdList
3795
Advantage
55
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
More
Less

View Lastest Price from 2-(Methylamino)pyridine-3-methanol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-(Methylamino)pyridine-3-methanol 32399-12-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10kg/month
Release date
2022-12-28
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Isavuconazole Impurity 37 32399-12-5
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-07-10
Henan Aochuang Chemical Co.,Ltd.
Product
2-(Methylamino)pyridine-3-methanol 32399-12-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29

32399-12-5, 2-(Methylamino)pyridine-3-methanolRelated Search:

2-(Hydroxymethyl)pyridine 3-Aminopyridine 2-Chloro-3-cyanopyridine 3-Hydroxypyridine m-Anisyl alcohol Pyridine Methanol Talniflumate NIXYLIC ACID Clonixin FLUNIXIN MEGLUMINE 2-(Methylamino)pyridine-3-carboxylic acid Niflumic acid 3-Pyridinemethanol 2-(Methylamino)pyridine 2-ANILINONICOTINIC ACID 2-(Methylamino)pyridine-3-methanol Clonixeril

  • [2-(Methylamino)-3-pyridyl]methanol
  • 2-(METHYLAMINO)-3-PYRIDINEMETHANOL 98%
  • 3-HYDROXYMETHYL 2-METHYLAMINO PYRIDINE
  • [2-(Methylamino)pyridin-3-yl]methanol
  • 2-(Methylamino)pyridine-3-methanol
  • 2-(N-Methylamino)-3-hydroxymethylpyridine
  • 2-(MethylaMino)-3-PyridineMethanol
  • 3-(Hydroxymethyl)-2-(methylamino)pyridine 98%
  • [2-(methylamino)-3-pyridinyl]methanol
  • 3-Pyridinemethanol, 2-(methylamino)-
  • -(N-Methylamino)-3-hydroxymethylpyridine
  • 2-(Methylamino)-3-pyridinemethanol (Isavuconazole Impurity)
  • -3-hydroxymethylpyridine
  • 2-(N-Methylamino)
  • Isavuconazole internediate
  • 32399-12-5
  • Hydroxymethyl's
  • Pyridines
  • Heterocycle-Pyridine series